A5068957189- HIV Research and Treatment
- Cancer-related Molecular Pathways
- Genomics, phytochemicals, and oxidative stress
- Anthropological Studies and Insights
- Advanced Breast Cancer Therapies
- Bioactive Compounds and Antitumor Agents
- Sirtuins and Resveratrol in Medicine
- Insect Pest Control Strategies
- Synthesis and Reactivity of Heterocycles
- HIV/AIDS drug development and treatment
- Bioactive Natural Diterpenoids Research
- Cancer Mechanisms and Therapy
- Neuropeptides and Animal Physiology
- Endometriosis Research and Treatment
- Immune Cell Function and Interaction
- HIV/AIDS Research and Interventions
- Neuroinflammation and Neurodegeneration Mechanisms
- Microtubule and mitosis dynamics
The Wistar Institute
2019-2023
Pontifical Catholic University of Puerto Rico
2014
Merck & Co., Inc., Rahway, NJ, USA (United States)
2010
Inhibition of cyclin-dependent kinases (CDKs) has emerged as an attractive strategy for the development novel oncology therapeutics. Herein is described utilization in vivo screening approach with integrated efficacy and tolerability parameters to identify candidate CDK inhibitors a suitable balance activity tolerability. This resulted identification SCH 727965, potent selective inhibitor that currently undergoing clinical evaluation.
Even though HIV-1 replication can be suppressed by combination antiretroviral therapy (cART) inflammatory processes still occur, contributing to comorbidities. Comorbidities are attributed variety of factors, including mediated inflammation. Several proteins mediate central nervous system (CNS) inflammation, Nef. Nef is an early protein, toxic neurons and glia sufficient cause learning impairment similar some deficits observed in associated neurocognitive disorders. To determine whether...
Despite effective combination antiretroviral therapy (cART), people living with HIV (PLWH) continue to harbor replication-competent and transcriptionally active virus in infected cells, which turn can lead ongoing viral antigen production, chronic inflammation, increased risk of age-related comorbidities. To identify new agents that may inhibit postintegration beyond cART, we screened a library 512 pure compounds derived from natural products identified (–)-hopeaphenol as an inhibitor...
A sterilizing or functional cure for HIV is currently precluded by resting CD4<sup>+</sup> T cells that harbor latent but replication-competent provirus. The "shock-and-kill" pharmacological ap-proach aims to reactivate provirus expression in the presence of antiretroviral therapy and target virus-expressing elimination. However, no latency reversal agent (LRA) date effectively clears viral reservoirs humans, suggesting a need new LRAs LRA combinations. Here, we screened 216 compounds from...
Combination antiretroviral therapy (cART) targets viral replication, but early protein production by astrocytes may still occur and contribute to the progression of HIV-1 associated neurocognitive disorders secondary complications seen in patients receiving cART. In prior work with our model, astrocytic Nef expression exhibits neurotoxic effects leading neurological damage, learning impairment, immune upregulation that induces inflammation lungs small intestine (SI). this follow-up study, we...
Background: Endometriosis is characterized by the growth of endometrial tissue in areas such as peritoneal cavity and colon causing pain discomfort. We have previously demonstrated that rats with explants subjected to stress showed a significant increase size lesions. Chemokine ligand 2 (CCL2) has been found be increased plasma women endometriosis perhaps contributing inflammatory process but effects on this cytokine are still unclear. Aim: Examine relationship between CCL2 expression rat...