A5048012805- Global Cancer Incidence and Screening
- Cancer-related Molecular Pathways
- LGBTQ Health, Identity, and Policy
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Cutaneous Melanoma Detection and Management
- Lung Cancer Treatments and Mutations
- Cancer survivorship and care
- Cancer Genomics and Diagnostics
- Head and Neck Cancer Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Melanoma and MAPK Pathways
- Ferroptosis and cancer prognosis
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Blood groups and transfusion
- BRCA gene mutations in cancer
- Clinical Nutrition and Gastroenterology
- Breast Cancer Treatment Studies
- Ubiquitin and proteasome pathways
- Cancer Risks and Factors
- Neuropeptides and Animal Physiology
- Pharmaceutical studies and practices
- Molecular Biology Techniques and Applications
- Prostate Cancer Treatment and Research
OHSU Knight Cancer Institute
2025
Moffitt Cancer Center
2019-2024
Ponce Health Sciences University
2016-2021
Complejo Hospitalario Universitario de Granada
2016
Hospital Universitario Virgen de las Nieves
2014-2015
University of Puerto Rico-Mayaguez
2013
Abstract The National Lung Screening Trial (NLST) demonstrated that screening with low-dose computed tomography (LDCT) is associated a 20% reduction in lung cancer mortality. One potential limitation of LDCT overdiagnosis slow growing and indolent cancers. In this study, peritumoral intratumoral radiomics was used to identify vulnerable subset patients poor survival outcomes. Incident from the NLST were split into training test cohorts an external cohort non-screen detected adenocarcinomas...
Abstract Background: Sexual and gender minority (SGM) populations are underserved minoritized. To aid in identifying real world cancer disparities among SGM patients, 2016 our institution began collecting sexual orientation identity (SOGI) on all patients. Leveraging these valuable data, this study analyzed differences between non-SGM patients for clinical characteristics quality-of-life (QoL). Methods: Data were acquired >118, 000 who completed the standard-of-care Electronic Patient...
Abstract Cancer is the leading cause of death in Puerto Rico (PR). Hurricane Maria (HM) and its aftermath lead to widespread devastation on island, including collapse healthcare system. Medically fragile populations, such as cancer survivors, were significantly affected. The goal this study was assess impact HM barriers care, emotional distress, inflammatory biomarkers among survivors PR. This exploratory longitudinal conducted health care facilities community support groups from (n = 50)...
In 2017, approximately 5 million Americans were living with Alzheimer's disease (AD), and it is estimated that by 2050 this number could increase to 16 million.In study, we apply mathematical optimization approach microarray analysis detect differentially expressed genes determine the most correlated structure among their expression changes.The of GSE4757 dataset, which compares between AD neurons without neurofibrillary tangles (controls) (cases), was casted as a multiple criteria (MCO)...
Multiple studies suggest that chronic stress accelerates the growth of existing tumors by activating sympathetic nervous system. Data sustained adrenergic signaling can induce tumor growth, secretion pro-inflammatory cytokines, and macrophage infiltration. Our goal was to study role adrenergic-stimulated macrophages in ovarian cancer biology. Cytokine arrays were used assess effect stimulation pro-tumoral cytokine networks. An orthotopic model vivo daily restraint on adrenergic-induced...
Underserved and minoritized patients with cancer often experience more psychosocial concerns inferior quality of life (QOL) compared majority populations. This study patient-reported characteristics QOL among self-identified sexual gender minority vs cisgender-heterosexual treated at a National Cancer Institute-designated comprehensive center in the United States.Self-report data from 51 503 were obtained an institutional standard-of-care electronic patient questionnaire that was completed...
Microarray experiments are capable of determining the relative expression tens thousands genes simultaneously, thus resulting in very large databases. The analysis these databases and extraction biologically relevant knowledge from them challenging tasks. identification potential cancer biomarker is one most important aims for microarray and, as such, has been widely targeted literature. However, identifying a set consistently across different experiments, researches, platforms, or types...
Image-based biomarkers could have translational implications by characterizing tumor behavior of lung cancers diagnosed during cancer screening. In this study, peritumoral and intratumoral radiomics volume doubling time (VDT) were used to identify high-risk subsets patients in screening that are associated with poor survival outcomes.Data images acquired from the National Lung Screening Trial. VDT was calculated between two consequent intervals approximately 1 year apart; extracted baseline...
Abstract Background Herein, we report the characterization of four cohorts breast cancer patients including (1) non-Hispanic Whites in Florida, (2) Blacks (3) Hispanics and (4) Puerto Rico. Methods Data from female were collected registry ( n = 9361) self-reported patient questionnaires 4324). Several statistical tests applied to identify significant group differences. Results Breast Rico least frequently employed had lowest rates college education among groups. They also reported more live...
Prediction of lung cancer metastasis relies on post-resection assessment tumor histology, which is a severe limitation since only minority patients are diagnosed with resectable disease. Therefore, characterization metastasis-predicting biomarkers in pre-resection small biopsy specimens urgently needed. Here we report biomarker consisting the phosphorylation retinoblastoma protein (Rb) serine 249 combined elevated p39 expression. This correlates epithelial-to-mesenchymal transition traits...
LGBT patients may have unique psychosocial cancer care needs, and healthcare providers should knowledge understanding of these needs to effectively address disparities through the delivery personalized healthcare. As such, our group developed piloted a web-based cultural competency training designed specifically for oncologists called Curriculum Oncologists on populations Optimize Relevance Skills (COLORS). We randomized pragmatic trial compare effectiveness COLORS versus general online in...
11000 Background: Published studies report oncologists have limited knowledge about LGBT health and cancer needs but also high interest in receiving education regarding the unique of patients with cancer. As such, our group developed Curriculum for Oncologists on populations to Optimize Relevance Skills (COLORS), an interactive web-based cultural sensitivity training that focused improving communication skill-building. We here results from two single-arm feasibility/acceptability trials one...
To reveal successes and potential limitations of the lung cancer screening program, we conducted a survey that included both quantitative open-ended questions to measure patient experiences satisfaction with screening.We report on five items related barriers returning for screening, experience other prevention screenings, positive negative experiences, suggestions improving future appointments. The responses were analyzed using constant comparison method inductive content...
Combination antiretroviral therapy (cART) targets viral replication, but early protein production by astrocytes may still occur and contribute to the progression of HIV-1 associated neurocognitive disorders secondary complications seen in patients receiving cART. In prior work with our model, astrocytic Nef expression exhibits neurotoxic effects leading neurological damage, learning impairment, immune upregulation that induces inflammation lungs small intestine (SI). this follow-up study, we...
Abstract Cancer is the leading cause of death in Puerto Rico (PR). Hurricane Maria (HM) and its aftermath lead to widespread devastation island, including collapse healthcare system. Medically fragile populations, such as cancer survivors, were significantly affected. The goal this study was assess impact HM on barriers care, emotional distress, inflammatory biomarkers among survivors PR. This exploratory longitudinal conducted health care facilities community support groups from (n=50)...
<h3>Background</h3> Gliomas are the most common primary brain tumours, accounting for 80% of malignant tumours central nervous system. Glioblastoma Multiforme (GBM), a grade IV glioma, is aggressive, with an overage overall survival (OS) 12 months, and prevalent, about 60–70% all gliomas. In recent years, chromosomal, genetic epigenetic mutations in GBM have been discovered under investigation to determinate their role clinical practice. <h3>Purpose</h3> To determine main biomarkers...
<h3>Background</h3> Some authors have described that among Hepatitis C Virus (HCV) genotype 1-infected patients treated with dual therapy, anaemia has been associated higher rates of Sustained Virological Response (SVR) as well the use erythropoiesis-stimulating agents. <h3>Purpose</h3> To investigate relationships between treatment outcomes, anaemia, and their management ribavirin dose reduction and/or darbepoetin in boceprevir (BOC) or telaprevir (TLV) a tertiary hospital. <h3>Material...
<h3>Background</h3> Imatinib was the first BCR-ABL tyrosine kinase inhibitor (TKI) available for chronic myeloid leukaemia (CML) treatment. Newer drugs, with a faster and better response, were subsequently developed. <h3>Purpose</h3> To analyse effectiveness safety of imatinib in CML patients. <h3>Material methods</h3> Retrospective, observational study. Patients who picked up our hospital (June 2011–June 2014), including those changed to second generation (2G)–TKI, included. Variables...
<h3>Background</h3> Soybean lipid emulsions in parenteral nutrition (PN) are associated with liver disease. This has led to the development of alternative intravenous (ILEs). <h3>Purpose</h3> To compare effects two new ILEs: Lipoplus (soybean fish oil) and Clinoleic olive oil). <h3>Material methods</h3> Retrospective observational study using pharmacotherapeutic records premature infants who started PN between December 2012 May 2014 a tertiary care hospital. We included requiring ≥5 days...