A5087816333- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- S100 Proteins and Annexins
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Crystal structures of chemical compounds
- Diabetes and associated disorders
- Vibrio bacteria research studies
- Cardiac Fibrosis and Remodeling
- Cholesterol and Lipid Metabolism
- Adipose Tissue and Metabolism
- Retinal Diseases and Treatments
- Nonlinear Optical Materials Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Protease and Inhibitor Mechanisms
- Regulation of Appetite and Obesity
- Fungal Plant Pathogen Control
- Antiplatelet Therapy and Cardiovascular Diseases
- Neurosurgical Procedures and Complications
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Retinoids in leukemia and cellular processes
- Metabolism, Diabetes, and Cancer
- Glycosylation and Glycoproteins Research
- Nanoparticles: synthesis and applications
- Aquaculture disease management and microbiota
University of Chicago
2024
B.S. Abdur Rahman Crescent Institute of Science & Technology
2023-2024
University of Alabama at Birmingham
2018-2021
The Ohio State University Wexner Medical Center
2020-2021
The Ohio State University
2019-2020
Norwegian Womens Public Health Association
2019
Shanmuganathan Engineering College
2019
PSG Institute of Medical Sciences & Research
2009
Myocardial infarction (MI) triggers myelopoiesis, resulting in heightened production of neutrophils. However, the mechanisms that sustain their and recruitment to injured heart are unclear. Using a mouse model permanent ligation left anterior descending artery flow cytometry, we first characterized temporal spatial effects MI on different myeloid cell types. We next performed global transcriptome analysis cardiac types within infarct identify drivers acute inflammatory response underlying...
There is incomplete knowledge of the impact bone marrow cells on gut microbiome and barrier function.We postulated that diabetes mellitus systemic ACE2 (angiotensin-converting enzyme 2) deficiency would synergize to adversely both function.Bacterial 16S rRNA sequencing metatranscriptomic analysis were performed fecal samples from wild-type, ACE2-/y, Akita (type 1 mellitus), ACE2-/y-Akita mice. Gut integrity was assessed by immunofluorescence, cell extravasation into small intestine evaluated...
We sought to delineate the retinal features associated with high-fat diet (HFD) mouse, a widely used model of obesity. C57BL/6 mice were fed either (60% fat; HFD) or low-fat (10% LFD) for up 12 months. The effect HFD on body weight and insulin resistance measured. retina was assessed by electroretinogram (ERG), fundus photography, permeability studies, trypsin digests enumeration acellular capillaries. cohort experienced hypercholesterolemia when compared LFD cohort, but not hyperglycemia....
Acute myocardial infarction (MI) results in overzealous production and infiltration of neutrophils to the ischemic heart. This is mediated part by granulopoiesis induced S100A8/A9-NLRP3-IL-1β signaling axis injury-exposed neutrophils. Despite transcriptional upregulation NLRP3 (Nod Like Receptor Family Pyrin Domain-Containing 3) inflammasome associated components neutrophils, serum levels IL-1β (interleukin-1β), effector molecule granulopoiesis, were not affected MI, suggesting that released...
Although the exercise derived activation of Nrf2 signaling augments myocardial antioxidant signaling, molecular mechanisms underlying benefits moderate training (MET) in heart remain elusive. Here we hypothesized that stabilizes Nrf2-dependent which then protects myocardium from isoproterenol-induced damage. The present study assessed effects 6 weeks MET on Nrf2/antioxidant function, glutathione redox state, and injury C57/BL6J mice received isoproterenol (ISO; 50 mg/kg/day for 7 days). ISO...
Syndecans are transmembrane proteoglycans that, like integrins, bind to components of the extracellular matrix. Previously, we showed significant associations genetic variants in Syndecan-4 (SDC4) gene with intra-abdominal fat, fasting plasma glucose levels, and insulin sensitivity index children, serum triglyceride levels healthy elderly subjects. An independent study also reported a correlation between SDC4 risk coronary artery disease middle-aged patients. Here, investigated whether...
In the title complex, [Hg(NCS) 2 (CH 4 N S) ], Hg II atom is four-coordinated having an irregular four-coordinate geometry composed of four thione S atoms two thiocyanate groups and thiourea groups. The S—Hg—S angles are 172.02 (9)° for trans -thiocyanate 90.14 (5)° cis -thiourea atoms. molecular structure stabilized by intramolecular N—H...S hydrogen bond, which forms (6) ring motif. crystal, molecules linked a number N—H...N bonds, forming three-dimensional framework. first report crystal...
Introduction Our study aims to retrospectively assess the safety of heparin during endovascular treatment ruptured intracranial aneurysms. Methods A retrospective analysis 56 patients who underwent aneurysmal repair for both and unruptured aneurysms was performed examine outcomes. Results This series included 41 females (73.2%) 15 males (26.8%) with a mean age 55.9 ± 15.2 years treated embolization which there were 30 26 total 22 received an intraoperative load before procedure ranging from...
Introduction The use of ticagrelor in the management acute stroke is becoming a more common practice, however, appropriate dosing regimen has not been extensively studied. Further, effectiveness relative to clopidogrel studied observational settings. This study evaluates two different strategies compared standard practice and associated outcomes. Methods We completed retrospective chart review patients diagnosed with ischemic at large academic comprehensive center from September 1, 2020,...
Eight different newly synthesised aldehyde Schiff base N-aryl thiosemicarbazones, differing in R, R' groups, are tested on 25 clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) and a standard strain. Antibacterial activity was carried out by well-diffusion method concentrations 15–500 μg/well. Compounds 1, 2, 3, 4 6 showed good inhibition MRSA. Increasing concentration the test compounds enlarged zone. Determination minimum inhibitory (MIC) using dilution susceptibility...
Myocardial infarction (MI) triggers myelopoiesis resulting in heightened number of neutrophils the circulation. However, mechanism that sustain their and recruitment to infarcted heart are unclear. Here, we show a mouse model MI (permanent ligation LAD), rapidly recruited infarct, where they release specific alarmins, S100A8 S100A9. These alarmins acting either an autocrine or paracrine manner, primed Nod Like Receptor (NLR) family Pyrin Domain Containing 3 (Nlrp3) inflammasome naïve via...