A5047139735- Inflammatory Myopathies and Dermatomyositis
- Systemic Lupus Erythematosus Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Muscle Physiology and Disorders
- Autoimmune and Inflammatory Disorders Research
- Neurogenetic and Muscular Disorders Research
- Systemic Sclerosis and Related Diseases
- Rheumatoid Arthritis Research and Therapies
- Atherosclerosis and Cardiovascular Diseases
- Immune Response and Inflammation
- Platelet Disorders and Treatments
- Nutrition and Health in Aging
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cleft Lip and Palate Research
- Prenatal Screening and Diagnostics
- Peripheral Neuropathies and Disorders
- Maternal and Neonatal Healthcare
- Immune cells in cancer
- Celiac Disease Research and Management
- Facial Trauma and Fracture Management
- Connective tissue disorders research
- Parkinson's Disease and Spinal Disorders
- Cell Adhesion Molecules Research
- Inflammasome and immune disorders
- Wound Healing and Treatments
The Ohio State University
2022-2024
University of Oklahoma Health Sciences Center
2024
The Ohio State University Wexner Medical Center
2020-2023
University of Alabama at Birmingham
2017-2020
University of Kentucky
2012-2015
Cleveland Clinic
2008
Universidade de São Paulo
2000-2007
Universidad San Pedro
2007
Esteve (Spain)
2001
Excel Diagnostics Imaging
2001
Myocardial infarction (MI) triggers myelopoiesis, resulting in heightened production of neutrophils. However, the mechanisms that sustain their and recruitment to injured heart are unclear. Using a mouse model permanent ligation left anterior descending artery flow cytometry, we first characterized temporal spatial effects MI on different myeloid cell types. We next performed global transcriptome analysis cardiac types within infarct identify drivers acute inflammatory response underlying...
Rheumatoid arthritis (RA) is associated with an approximately two-fold elevated risk of cardiovascular (CV)-related mortality. Patients RA present systemic inflammation including raised circulating myeloid cells, but fail to display traditional CV risk-factors, particularly dyslipidaemia. We aimed explore if increased cells impaired atherosclerotic lesion regression or altered progression in RA. Using flow cytometry, we noted prominent monocytosis, neutrophilia, and thrombocytosis two mouse...
Skeletal muscle dysfunction is a common extrapulmonary manifestation of chronic obstructive pulmonary disease (COPD). Alterations in skeletal myosin heavy chain expression, with reduced type I and increased II are associated COPD severity when studied largely male cohorts. The objectives this study were (1) to define an abnormal myofibre proportion phenotype both males females (2) identify transcripts transcriptional networks COPD.
To investigate the association of low-density (lipid-rich) muscle measured by computed tomography (CT) with skeletal function and health-related quality life in idiopathic inflammatory myopathies (IIMs).Seventeen patients 10 healthy controls underwent CT midthigh to quantify high- (30-100 HU) (0-29 areas. Anthropometric measures, body composition, physical activity level, life, strength, endurance, fatigue were assessed. Patients compared against controls. The relationship anthropometric,...
Rheumatoid arthritis (RA), an inflammatory joint disorder, independently increases the risk of cardiovascular disease (CVD). IL-1β contributes to both RA and CVD. We hypothesised that inhibiting IL-1 signalling with IL-1R antagonist, anakinra, would dampen inflammation promote resolution atherosclerosis in arthritic mice.Low-density lipoprotein receptor (Ldlr)-deficient mice were fed a Western-type diet for 14 weeks develop atherosclerotic plaques. Mice then switched chow diet, promoting...
Abstract Background In rheumatoid cachexia (RC), high resting energy expenditure (REE) is associated with loss of muscle mass driven by proinflammatory cytokines. The objectives this study were to investigate parameters RC and the interaction between systemic inflammation modifiable risk factors for on REE. Methods Thirty‐five arthritis (RA) 19 non‐RA controls comparable in age/sex/race/body index (BMI) underwent measures REE indirect calorimetry. Homeostasis model assessment insulin...
Objetivos: avaliar casos de fenda facial fetal quanto ao tipo lesão, associação com outras malformações e aneuploidias. Métodos: as fendas faciais foram estudadas a idade materna antecedentes, gestacional no diagnóstico, lado da presença associadas e/ou aneuploidias, mortalidade seguimento pós-natal. Resultados: em 40 fetos fenda, lesão era labial pura 18 (45%), labiopalatina 19 (47,5%) palatina 3 (7,5%). Em 10 isolada (25%), todas unilaterais. No grupo associadas, aneuploidia esteve...
Abstract Background Insulin resistance affects a substantial proportion of patients with rheumatoid arthritis (RA). Skeletal muscle mitochondrial dysfunction results in the accumulation lipid intermediates that interfere insulin signaling. We therefore sought to determine if lower oxidative phosphorylation and content are associated RA. Methods This was cross-sectional prospective study RA patients. Matsuda index from glucose tolerance test used estimate sensitivity. Mitochondrial measured...
Abstract This report describes a novel sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS–PAGE) resolving format that consistently yields the electrophoretic separation of fast and slow isoforms human sarcomeric myosin light chain 1 (MLC1). The inclusion methanol as constituent impacted mobility proteins across broad range molecular masses. There was greater MLC1, well high resolution three heavy are expressed in skeletal muscle on same format. Furthermore, substantially altered...
Abstract Objectives The leading cause of mortality in patients with rheumatoid arthritis is atherosclerotic cardiovascular disease (CVD). We have shown that murine impairs lesion regression, because cellular cholesterol efflux defects haematopoietic stem and progenitor cells (HSPCs), causing monocytosis impaired regression. Therefore, we hypothesised improving using a Liver X Receptor (LXR) agonist would improve regression arthritis. Methods Ldlr −/− mice were fed western‐type diet for 14...
OBJETIVO: Determinar a contribuição da sutura borda, tarso e pele na resistência pálpebra à ruptura pós-reconstrução. MÉTODOS: estudo prospectivo, mascarado em coelhos, que foram submetidos ressecção de um fragmento espessura total pálpebra. Os animais distribuidos cinco grupos: G1 três planos; G2 palpebral sem inclusão do tarso; G3 pele; G4 borda palpebral; G5 igual ao Grupo 1. Grupo1 4 sacrificados no 7º.dia os 5 2º. dia. espécimes palpebrais teste rompimento com tensiômetro. RESULTADOS:...
<h3>Background</h3> Many patients with IIMs exibit chronic muscle weakness and functional disability despite treatment. In polymyositis/ dermatomyositis (PM/DM), male sex, higher prednisone dosage older age have been associated disability.[1,2] Sporadic inclusion body myositis (sIBM) itself is major end-stage disability.[3] The ACR status (ACRFS) criteria used as a core measure of the consequences impairment in IIM.[4] However, its association known or suspected risk factors warrants further...
<h3>Background</h3> IIM are systemic autoimmune diseases characterized by chronic inflammation in skeletal muscle leading to proximal weakness. In rheumatoid arthritis, weakness has been linked specific changes architecture that measureable using ultrasound (US).<sup>1</sup> However, data regarding the contribution of is lacking. US a non-invasive, relatively inexpensive and validated method assessing architectural parameters [i.e. anatomic cross sectional area (ACSA), fascicle length (Lf),...
<h3>Background</h3> Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that leads to progressive joint destruction involving multiple joints. There large body of evidence suggests crucial role for activated synovial fibroblasts (RASF) in mediating both direct tissue injury and perpetuation the complex process RA [1]. RASF from patients are able attach articular cartilage deeply invade degrade matrix [2] have been shown migrate secondary locations <i>in vivo</i> similarly...
OBJETIVO: Desenvolvimento de método treinamento prático em cirurgia palpebral baseado modelo animal, orientado para o oftalmologista geral e iniciante palpebral. MÉTODOS: O porcino foi selecionado devido à semelhança com relação pálpebra humana. Após breve estudo dirigido material didático abordando aspectos básicos roteiro detalhado dos procedimentos a serem realizados, passou-se ao prático. As técnicas abordadas foram ressecção pentagonal reconstrução direta por planos da técnica original...