A5000045730- Thyroid Cancer Diagnosis and Treatment
- BRCA gene mutations in cancer
- Oral and Maxillofacial Pathology
- Glioma Diagnosis and Treatment
- Renal cell carcinoma treatment
- Epilepsy research and treatment
- Cancer, Hypoxia, and Metabolism
- Receptor Mechanisms and Signaling
- Genomics and Chromatin Dynamics
- Vascular Tumors and Angiosarcomas
- Chemical Synthesis and Analysis
- Innovative Microfluidic and Catalytic Techniques Innovation
- Platelet Disorders and Treatments
- Ear and Head Tumors
- Mechanical Circulatory Support Devices
- Genetic factors in colorectal cancer
- Sarcoma Diagnosis and Treatment
- Bioinformatics and Genomic Networks
- Neuroblastoma Research and Treatments
- Venous Thromboembolism Diagnosis and Management
- Tuberous Sclerosis Complex Research
- Tumors and Oncological Cases
- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- Systemic Lupus Erythematosus Research
University of Pittsburgh Medical Center
2019-2025
University of Pittsburgh
2019-2025
UPMC Presbyterian
2019-2024
UPMC Health System
2023
Presbyterian Hospital
2019
INTEGRIS Baptist Medical Center
2013
Background: Molecular testing is increasingly used to refine the probability of cancer and assess recurrence risk in thyroid nodules with Bethesda III/IV fine needle aspiration (FNA) cytology. However, limited data exist for V (suspicious malignancy [SFM]) samples. This study evaluated performance ThyroSeq v3 (TSv3) SFM Methods: In this single-institution retrospective cohort study, consecutive FNA samples diagnosed as TSv3 known surgical outcome were identified. Clinical, pathology,...
Microarray-based methylation profiling has emerged as a valuable tool for refining diagnoses and revealing novel tumor subtypes, particularly in central nervous system tumors. Despite the increasing adoption of this technique clinical genomic laboratories, no technical standards have been published establishing minimum criteria test validation. A working group with experience expertise DNA-based tests on CNS tumors collaborated to develop practical discussion points focus important...
Background Acinic cell carcinoma (AcCC) is diagnostically challenging on fine‐needle aspiration because it can mimic several other neoplasms or even normal acinar tissue. Immunopositivity for DOG1, especially circumferential membranous staining, support the diagnosis of AcCC but not entirely specific, and prone to technical interpretive challenges small specimens. NR4A3 (nuclear receptor subfamily 4 group A member 3) translocation nuclear overexpression were recently described in majority...
Abstract A putative molecular subtype of IDH-wildtype diffuse glioma with recurrent MAPK pathway alterations has recently been reported. By dimensionality reduction analysis genome-wide methylation profiling, these tumors form a distinct cluster gliomas. Characterization 47 from 45 patients reveals that gliomas are predominantly supratentorial in young adults, highly infiltrative, and harbor mitogen-activated protein kinase (MAPK) high rates CDKN2A/2B deletion, PDGFRA amplification, MYCN NF1...
Abstract Low‐grade epilepsy‐associated tumors (LEATs) are a common cause of drug‐resistant epilepsy in children. Herein, we demonstrate the feasibility using tumor tissue derived from stereoelectroencephalography (sEEG) electrodes upon removal to molecularly characterize and aid diagnosis. An 18‐year‐old male with focal MRI suggestive dysembryoplastic neuroepithelial (DNET) left posterior temporal lobe underwent implantation seven peri‐tumoral sEEG for peri‐operative language mapping...
This study established the performance characteristics of DOAC-Remove for neutralization effects rivaroxaban and apixaban in lupus anticoagulant (LAC) testing.Normal donor, LAC control, patient samples were spiked with or to simulate their on dilute Russell's viper venom time (dRVVT), activated partial thromboplastin (APTT), prothrombin (dPT). Anti-Xa activity was measured after spiking neutralization. Accuracy, complex precision, reference interval verification evaluated.DOAC-Remove...
Background Immunoassays are commonly used to test for drugs of abuse in patients a variety settings. The increasing prevalence ‘designer’ causes difficulties the toxicology laboratory and may result unexpected false positives identification unfamiliar compounds. Within past decade, there have been ketamine phencyclidine analogues identified, particularly as abuse. Method We present case intoxication with novel analogue, deschloro-N-ethyl-ketamine, causing positive immunoassay. Additionally,...
Abstract Introduction Thyroid cytopathology cases with suspicious for malignancy (SFM) diagnosis often result in resection. However, molecular testing offers details that may provide additional insights. In this study, the profiles of SFM from two institutions routinely used ThyroSeq v3 (TSV3) were examined. Materials and Methods Following institutional review board approval, thyroid TSV3 results retrieved databases institutions. Molecular information including molecular‐derived risk...
Tumors are increasingly defined by molecular alterations but approach to cases with discordant histologic and features is unclear. Myxoid glioneuronal tumor (MGNT), histologically similar dysembryoplastic neuroepithelial (DNET), characterized dinucleotide mutations in
Renal cell carcinoma (RCC) is the most common type of cancer found to metastasize thyroid gland. These tumors may represent a diagnostic challenge in cytology. However, RCC carry VHL alterations, which are rare primary tumors. The aim this study was evaluate utility molecular testing detecting metastatic fine-needle aspiration (FNA) samples. From November 2017 until March 2022, FNA samples with ThyroSeq v3 results showing both alterations and low/absent expression markers were analyzed....