A5085222924- Liver Disease Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Salivary Gland Tumors Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Tumors and Oncological Cases
- Tracheal and airway disorders
- Ear and Head Tumors
- Neuroendocrine Tumor Research Advances
- Sarcoma Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Gastroesophageal reflux and treatments
- Liver Disease and Transplantation
- Gastric Cancer Management and Outcomes
- Liver Diseases and Immunity
- Pediatric Hepatobiliary Diseases and Treatments
- COVID-19 and healthcare impacts
- Head and Neck Surgical Oncology
- Cancer Immunotherapy and Biomarkers
- Genetics and Neurodevelopmental Disorders
- Eosinophilic Esophagitis
- Lung Cancer Treatments and Mutations
University of Toronto
1987-2025
Sinai Health System
2023-2025
University of Pittsburgh
2024
Sinai Health System
2024
Mount Sinai Hospital
2024
Toronto General Hospital
2022-2023
University Health Network
2021-2023
Canada Research Chairs
2020
Queen's University
2018
Sunnybrook Health Science Centre
2018
The classification of salivary gland tumors is ever-evolving with new variants being described every year. Next-generation sequencing panels have helped to prove and disprove prior assumptions about tumors' relationships one another, refine this classification. Adenoid cystic carcinoma (AdCC) the most common malignancies occurs at all major minor seromucous sites. Most AdCC are predominantly myoepithelial basaloid variable cribriform, tubular, solid growth. luminal tubular elements often...
Exome sequencing is the current standard for diagnosing Mendelian disorders; however, it generally not considered first-line test detecting copy number variants (CNVs). We retrospectively investigated additional diagnostic yield by performing concurrent CNV analysis using exome data in a large and diverse pediatric cohort. Patients were referred from various sources with variable phenotypes. Human Phenotype Ontology terms used to prioritize analysis. Ancestry analyses performed Somalier...
Aims Recently, HMGA2::WIF1 fusion has been reported in pleomorphic adenoma (PAs) originating from the parotid gland with a characteristic canalicular (CAA)‐like pattern. However, it is unclear whether may occur salivary carcinoma or tumours minor glands. We herein conducted detailed clinicopathological review of eight harbouring fusions. Methods and results The reviewed diagnoses neoplasms were PA ( n = four), myoepithelioma one), myoepithelial ex two) high‐grade basaloid features one). Two...
The landscape of salivary gland carcinomas is ever-changing, with a growing list new tumors and newly elucidated variants well-known tumor entities. routine use next-generation sequencing has been instrumental in identifying novel fusions entities, which helped bring the classification to more objective evidenced-based model. However, morphology remains critical assessing validity these molecular findings, most importantly, findings will have an impact on prognosis treatment decisions for...
<i>Background:</i> ‘Functional relaxation’ (FR) according to Marianne Fuchs is a body-oriented psychotherapy that involves teaching the patient type of relaxation techniques aimed at maintaining equilibrium nervous system. <i>Methods:</i> In order determine whether practice elementary parts this therapy has an immediate beneficial effect on pulmonary function, randomized, single-blind, prospective crossover study was done with 21 asthmatics acute bronchoconstriction....
Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
Background and aim Head neck nuclear protein of testis carcinoma (HN‐NUT) is a rare form diagnosed by NUT immunohistochemistry positivity and/or NUTM1 translocation. Although the prototype HN‐NUT primitive undifferentiated round cell tumour (URC) with immunopositivity for squamous markers, it our observation that may assume variant histology or immunoprofile. Methods We conducted detailed clinicopathological review large retrospective cohort 30 HN‐NUT, aiming to expand its histological...
Background Variant classification in the setting of germline genetic testing is necessary for patients and their families to receive proper care. Variants are classified as pathogenic (P), likely (LP), uncertain significance (VUS), benign (LB) (B) using standards guidelines recommended by American College Medical Genetics Association Molecular Pathology, with modifications specific genes. As literature continues rapidly expand, evidence accumulate, prior classifications can be updated...
Background: 'Functional relaxation' (German: 'Funktionelle Entspannung') has been developed since 1944 by the German physiotherapist M. Fuchs. It is based on concentrating body perception while moving joints of skeleton smoothly and at same time breathing out. This procedure induces a physical emotional relaxation in many cases. The aim study was to compare efficiency standardized elements somatopsychotherapy (eFE) bronchodilatative test using terbutaline (IT). Methods: Seventeen asthmatic...
Adrenomedullin is a multi-functional polypeptide hormone. Its involvement in angiogenesis and vasodilator action support the hypothesis that adrenomedullin may be secretory product of neuroendocrine tumors contribute to tumor progression. Plasma levels were measured by radioimmunoassay 46 patients with carcinomas gastroenteropancreatic bronchial system. Tissue expression was studied using monoclonal antibodies on pretreated paraffin embedded tissues group 31 patients. plasma significantly...
Aims We undertook a systematic evaluation of the prognostic value numerous histological factors in 165 radical cystectomies (RCs) patients with invasive urothelial carcinoma (UC) who underwent surgery after neoadjuvant chemotherapy (NAC). Methods and Results Tumour regression grade (TRG) therapy‐related stromal epithelial changes were also recorded. Locally advanced disease (≥pT2 and/or pN+) was present 64% patients, 22% had no evidence residual (pT0 + pN0), 28% muscle‐invasive (≤pT1 N0)....
Background and Study Aims: Patients who have had a colorectal adenoma are likely to develop metachronous adenoma, therefore need be kept under surveillance. The question is whether adenomas will found at the same anatomical site as preceding adenomas, thus prompting us focus surveillance examinations on this region, using flexible sigmoidoscopy or total colonoscopy.
Tumour-induced immunosuppression plays a role in the development and progression of cancer. Of interest is interaction between programmed death-1 death ligand-1 (PD-L1) which can be targeted through immune checkpoint blockade; however, there are limited data surrounding composition milieu prostate We preliminarily assessed 21 radical prostatectomies therapy-naïve patients for markers PD-L1 expression. The infiltrates were higher adenocarcinoma than benign (lymphocytes p<0.001, macrophages...
Complementary medicine is being used to varying extent in all industrial countries. There are incomplete data concerning efficacy, safety and costs of such treatment, while little known about special features motivation those persons who choose complementary medicine. The aim the study was ascertain, among patients use prefer traditional medicine, any differences with regard sociodemographic, disease-related psychological characteristics their life-style.A total 419 were studied by a...
Context.— Resident physicians face a higher rate of burnout and depression than the general population. Few studies have examined in Canadian laboratory medicine residents, none during COVID-19 pandemic. Objective.— To identify prevalence depression, contributing factors, impact this Design.— An electronic survey was distributed to residents. Burnout assessed using Oldenburg Inventory. Depression Patient Health Questionnaire 9. Results.— Seventy-nine responses were collected. The 63% (50...
The Niagara Health System (NHS) in Ontario, Canada is comprised of three non-designated trauma center (NTC) hospitals which provide primary care to approximately 100 patients annually. NTCs often lack standardized resources such as surgeons, trauma-trained emergency room physicians, Advanced Trauma Life Support certified staff, protocols, and other commonly found at designated centers. Studies indicate that these differences contribute poorer outcomes for treated community including the NTC...