A5018618638- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Radiomics and Machine Learning in Medical Imaging
- COVID-19 and healthcare impacts
- Intestinal Malrotation and Obstruction Disorders
- Anatomy and Medical Technology
- Neurological disorders and treatments
- AI in cancer detection
- Healthcare professionals’ stress and burnout
- Congenital Diaphragmatic Hernia Studies
- Mast cells and histamine
- Neurological diseases and metabolism
- Healthcare Systems and Reforms
- Urticaria and Related Conditions
- Gastrointestinal disorders and treatments
- Eosinophilic Esophagitis
- Cancer, Lipids, and Metabolism
- Medical Imaging and Pathology Studies
- Global Maternal and Child Health
- Celiac Disease Research and Management
- Child Nutrition and Water Access
Princeton University
2025
University of Toronto
2019-2024
Sinai Health System
2023
Sinai Health System
2021-2023
Mount Sinai Hospital
2020-2023
Sunnybrook Health Science Centre
2020
Health Sciences Centre
2020
Hospital for Sick Children
2019
To develop and validate a deep learning algorithm to quantify broad spectrum of histological features in colorectal carcinoma.A was trained on haematoxylin eosin-stained slides from tissue microarrays carcinomas (N = 230) segment carcinoma digitised images into 13 regions one object. The segmentation demonstrated moderate almost perfect agreement with interpretations by gastrointestinal pathologists, applied an independent test cohort whole 136). correctly classified mucinous high-grade...
Abstract Background The epidemiology of colonization with ESCrE in the community low- and middle-income countries (LMICs) is largely uncharacterized. In community, household particular importance as it setting which individuals spend a majority their time. Identifying risk factors for critical to inform antibiotic resistance reduction strategies LMICs. Methods Participants were enrolled from 1/1/20-9/4/20, pause 4/2/20-5/21/20 due country-wide COVID lockdown. This study was conducted 6...
Tumor budding (TB) and poorly differentiated clusters (PDCs) are powerful prognostic factors in colorectal cancer (CRC). Despite their morphologic biological overlap, TB PDC assessed separately distinguished by an arbitrary cutoff for cell cluster size. This can be challenging to apply practice its significance remains unclear. We developed a novel scoring system that incorporates into single parameter ("Combined Score"; CS), eliminating the need such cutoffs allowing value of captured...
Venous invasion (VI) is a powerful yet under-reported prognostic factor in colorectal cancer (CRC). Efforts to improve its detection have largely focused upon histological assessment, with less attention paid tissue-sampling strategies. This study aimed prospectively determine the number of tumour blocks required optimise VI CRC resections. In addition, relationship between linear spiculation (LS) and extramural venous (EMVI) was investigated.A standardised tissue sampling protocol developed...
Venous invasion (VI) is a powerful yet underreported prognostic factor in colorectal cancer (CRC). Its detection can be improved with an elastin stain. We evaluated the impact of routine staining on VI resected CRC and its relationship oncologic outcomes. Pathology reports from year before (n=145) following (n=128) implementation at our institution were reviewed for established factors, including VI. A second review, using stains, documented presence/absence, location, number, size foci. The...
Tumor budding (TB) is a powerful prognostic factor in colorectal cancer (CRC). An internationally standardized method for its assessment (International Budding Consensus Conference [ITBCC] method) has been adopted by most CRC pathology protocols. This requires that TB counts are reported field area (0.785 mm 2 ) rather than objective lens and normalization applied this purpose. However, the validity of approach yet to be tested. We sought validate ITBCC with particular emphasis on as tool...
Context.— Resident physicians face a higher rate of burnout and depression than the general population. Few studies have examined in Canadian laboratory medicine residents, none during COVID-19 pandemic. Objective.— To identify prevalence depression, contributing factors, impact this Design.— An electronic survey was distributed to residents. Burnout assessed using Oldenburg Inventory. Depression Patient Health Questionnaire 9. Results.— Seventy-nine responses were collected. The 63% (50...
162 Background: There is a need to improve current risk stratification of stage II and III colorectal cancer (CRC) better inform recurrence guide adjuvant chemotherapy. The purpose this study examine whether integration QuantCRC, an AI-based digital pathology biomarker utilizing hematoxylin eosin-stained slides, provides improved over American Society Clinical Oncology (ASCO) guidelines. Methods: ASCO QuantCRC-integrated schemes were applied observational cohort 1,068 CRCs. integrated scheme...
Venous invasion (VI) is a powerful prognostic factor in colorectal cancer (CRC) that widely underreported. The ability of elastin stains to improve VI detection now recognized several international CRC pathology protocols. However, concerns related the cost and time required perform evaluate these addition routine hematoxylin eosin (H&E) remains barrier their wider use. We therefore sought determine whether an trichrome (ET) stain could be used as “stand-alone” resections, by comparing...
114 Background: ExtraMural Venous Invasion (EMVI) is considered an indicator of poor prognosis in patients who have undergone resection primary CRC, but its use has not been widely adopted staging systems or nomograms. Staining for elastin may facilitate the accurate detection EMVI and minimize interobserver variability, as well enable assessment specific features including focality size. We examined prognostic potential detected by staining at a tertiary center that performs high volume CRC...