A5074528069- Prenatal Screening and Diagnostics
- Colorectal Cancer Treatments and Studies
- Neonatal and fetal brain pathology
- Fetal and Pediatric Neurological Disorders
- Potassium and Related Disorders
- Cardiovascular Function and Risk Factors
- Immune cells in cancer
- Mycobacterium research and diagnosis
- Antifungal resistance and susceptibility
- CNS Lymphoma Diagnosis and Treatment
- Lysosomal Storage Disorders Research
- Fungal Infections and Studies
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Surgical Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Viral-associated cancers and disorders
- Soft tissue tumor case studies
- Biomedical Text Mining and Ontologies
- Genetic Syndromes and Imprinting
- Phytoplasmas and Hemiptera pathogens
- Parathyroid Disorders and Treatments
- Lymphoma Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Sarcoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
Sinai Hospital
2024
Mount Sinai Hospital
2023-2024
University of Toronto
2023-2024
Rambam Health Care Campus
2016-2021
Technion – Israel Institute of Technology
1996-2021
Hadassah Medical Center
2021
Abstract Calcified chondroid mesenchymal neoplasms represent a distinct, and recently recognized, spectrum of tumors. To date most cases have been reported to be characterized by FN1 gene fusions involving multiple potential tyrosine kinase partners. Following incidental identification tumor morphologically corresponding calcified neoplasm, but with PDGFRA::USP8 fusion, we undertook retrospective review identify characterize additional such cases. A total four tumors were identified. Each...
Background Variant classification in the setting of germline genetic testing is necessary for patients and their families to receive proper care. Variants are classified as pathogenic (P), likely (LP), uncertain significance (VUS), benign (LB) (B) using standards guidelines recommended by American College Medical Genetics Association Molecular Pathology, with modifications specific genes. As literature continues rapidly expand, evidence accumulate, prior classifications can be updated...
Abstract Objective To describe the association between prenatal imaging and neurodevelopmental outcomes of fetuses with rhombencephalosynapsis (RES). Study design Thirty‐four pregnancies complicated by RES were identified from our institutional databases based on US and/or MRI findings. Genetic testing results gathered. In cases termination pregnancy, we studied neuropathologic For those who opted for expectant management, comprehensive developmental assessments postnatal evaluated. Results...
ABSTRACT Pancreatic tumors are uncommon in children and rarely result biliary obstruction. Primary pancreatic Burkitt's lymphoma is an exceptionally rare entity with only a few cases described the literature. We present case of bifocal primary 4‐year‐old child presenting jaundice. © 2016 Wiley Periodicals, Inc. J Clin Ultrasound 45 :171–174, 2017
Background: More than 50 different monogenic disorders have been identified as directly causing inflammatory bowel diseases, typically manifesting in the first years of life. We present clinical course and immunological work-up an adult patient who presented adolescent with atypical gastrointestinal phenotype, was diagnosed more two decades later a disorder important therapeutic implications. Methods: Whole exome sequencing performed 37-years-old history diarrhea since adolescence. Sanger...
Capecitabine-based neoadjuvant chemoradiation therapy (nCRT) is currently the mainstay of treatment for locally advanced rectal cancer (LARC), prior to surgical tumor removal. While response this partial, it carries significant risk side effects. As today, there no accepted model predict response, and allow patient stratification. The level circulating Myeloid-derived suppressor cells (MDSCs), a subpopulation early myeloid (EMCs), has been shown correlate with prognosis in colon cancer, but...
We present an autochthonous Histoplasma infection in Israel. The patient presented with hoarseness and weight loss. Pathology findings molecular tests confirmed the diagnosis, responded to antifungal therapy. Because had atypical presentation of histoplasmosis, it is likely that other more typical cases have gone unreported. To our knowledge, no been previously reported from Israel or Middle East region.
Incorporating artificial intelligence (AI) into digital pathology offers promising prospects for automating and enhancing tasks such as image analysis diagnostic processes. However, the diversity of tissue samples necessity meticulous labeling often result in biased datasets, constraining applicability algorithms trained on them. To harness synthetic histopathological images to cope with this challenge, it is essential not only produce photorealistic but also be able exert control over...
Mesencephalosynapsis is characterized by a failure of the dorsal brainstem colliculi to separate into distinct lateral masses (non-cleavage, a.k.a. "fusion"). It linked ventriculomegaly and aqueductal stenosis but other associations have not been systematically examined. We reviewed large cohort fetal hydrocephalus cases explore stenosis, mesencephalosynapsis, pathologies. Among 115 obstructive (15-41 weeks gestation), mesencephalosynapsis was seen in 44 (38.3%). graded wide range abnormal...
Nodular sclerosing Hodgkin lymphoma (HL) has an excellent prognosis in children. The syncytial variant (SV) of HL adults represents a clinic pathologic entity with worse outcome. We report the clinical features and course disease three children refractory HL. patients SV were analyzed retrospective multi-institutional study conducted Israel 51 diagnosed or recurrent between 1997 2014. All developed multiple recurrences soon after diagnosis. received at least different chemotherapy...