A5075294275- Glioma Diagnosis and Treatment
- Mesenchymal stem cell research
- Neurofibromatosis and Schwannoma Cases
- Neuroblastoma Research and Treatments
- Migration, Identity, and Health
- Cancer Cells and Metastasis
- Healthcare Systems and Practices
- Complement system in diseases
- SARS-CoV-2 and COVID-19 Research
- Extracellular vesicles in disease
- Brain Metastases and Treatment
- Cell Adhesion Molecules Research
- Colorectal Cancer Screening and Detection
- Global Public Health Policies and Epidemiology
- Inflammatory Biomarkers in Disease Prognosis
- Neonatal Respiratory Health Research
- Angiogenesis and VEGF in Cancer
- COVID-19 Clinical Research Studies
- Circular RNAs in diseases
- Genomics and Chromatin Dynamics
- Ear and Head Tumors
- interferon and immune responses
- Peripheral Neuropathies and Disorders
- Immune cells in cancer
- Childhood Cancer Survivors' Quality of Life
Peuplements végétaux et bioagresseurs en milieu tropical
2021-2025
Centre Hospitalier Universitaire de La Réunion
2020-2025
Inserm
2025
Écologie Marine Tropicale des Océans Pacifique et Indien
2023
Observatoire des Sciences de l'Univers de la Réunion
2022
Centre Hospitalier Universitaire d'Angers
2019-2020
Université d'Angers
2019
Inhibition of adenosine A2A receptor (A2AR) is a promising approach for cancer immunotherapy currently evaluated in several clinical trials. We here report that anti-obesogenic and anti-inflammatory functions A2AR, however, significantly restrain hepatocellular carcinoma (HCC) development. Adora2a deletion mice triggers obesity, non-alcoholic steatohepatitis (NASH), systemic inflammation, leading to spontaneous HCC promoting dimethylbenzyl-anthracene (DMBA)- or diethylnitrosamine...
The complement (C) innate immune system has been shown to be activated in the tumor microenvironment of various cancers. C may support growth by modulating response and promoting angiogenesis through actions anaphylatoxins (e.g., C5a, C3a). important double-edged sword functions brain, but little is known about its role brain tumors. Hence, we analyzed distribution regulated expression C3a receptor C3aR primary secondary We found that was dramatically upregulated Grade 4 diffuse gliomas,...
CD248 (endosialin) belongs to a glycoprotein family that also includes thrombomodulin (CD141), CLEC14A, and CD93 (AA4) stem cell markers. We analyzed the regulated expression of in vitro using skin (HFFF) synovial (FLS) mesenchymal lines, fluid tissue samples rheumatoid arthritis (RA) osteoarthritis (OA) patients. Cells were incubated with either rhVEGF165, bFGF, TGF-β1, IL1-β, TNF-α, TGFβ1, IFN-γ, or PMA (Phorbol ester). There was no statistically significant change membrane expression. A...
Glioblastoma (GBM) is the most frequent and aggressive form of glioma. It characterized by marked genomic instability, which suggests that chromothripsis (CT) might be involved in GBM initiation. Recently, CT has emerged as an alternative mechanism cancer development, involving massive chromosome rearrangements a one-step catastrophic event. The aim study was to detect identify novel gene fusions regions. One hundred seventy IDH-wild-type were screened for patterns using whole-genome single...
The complement system plays a crucial role in cancer development. Our study investigated the of C3a anaphylatoxin on tumor microenvironment. models consisted mesenchymal stem cells (MSC-like, 3T3-L1), macrophages (Raw 264.7 Blue, (RB)) and (melanoma B16/F0). Recombinant mouse (Mo) (rC3a) was produced CHO transfected with Mo-IL10-signal peptide-Mo plasmid construct. effects rC3a, IFN-γ, TGF-β1, LPS were tested expression C3, C3aR, PI3K, cytokines, chemokines, transcription factors,...
Old world alphaviruses (e.g., chikungunya) are known to cause severe acute and chronic debilitating arthralgia/arthritis. However, atypical neurological manifestations and, in particular, unexpected cases of inflammatory Guillain–Barre syndrome (GBS) have been associated with the arthritogenic alphaviruses. The pathogenesis alphavirus-associated GBS remains unclear. We herein addressed for first time role Schwann cells (SC) peripheral neuropathy post-alphaviral infection using prototypical...
CD248 (endosialin/tumor endothelial marker 1) is upregulated in cancer, including colorectal cancer (CRC), but its exact role tumor progression remains to be elucidated. Previous studies have shown that the extracellular domain of mediates interaction between cells and matrix proteins interfering with this may reduce invasion migration activities. We examined expression 117 human CRC samples by immunohistochemistry investigated association various clinicopathologic features, occurrence...
Abstract BACKGROUND Primary central nervous system tumors (PCNST) in children aged 0 to 19 years are a heterogeneous group of pathological entities that continue present significant challenges. This abstract provides exhaustive data on histologically confirmed pediatric PCNST cases France. MATERIAL AND METHODS Patients were identified from the French Brain Tumor Database, comprehensive national database. The study included (0 years) who diagnosed with between 2006 and 2015. For each...