A5100639923- Advanced Chemical Physics Studies
- RNA and protein synthesis mechanisms
- ATP Synthase and ATPases Research
- Cellular transport and secretion
- Erythrocyte Function and Pathophysiology
- RNA Research and Splicing
- Corrosion Behavior and Inhibition
- Yersinia bacterium, plague, ectoparasites research
- Biochemical effects in animals
- Renal and related cancers
- Bioinformatics and Genomic Networks
- Spectroscopy and Quantum Chemical Studies
- Protein Structure and Dynamics
- Renal and Vascular Pathologies
- Influenza Virus Research Studies
- Microfluidic and Capillary Electrophoresis Applications
- Machine Learning in Materials Science
- RNA modifications and cancer
- Extracellular vesicles in disease
- Membrane-based Ion Separation Techniques
- Cancer-related gene regulation
- Nanopore and Nanochannel Transport Studies
- DNA and Nucleic Acid Chemistry
- Cancer Research and Treatments
- Lipid Membrane Structure and Behavior
Westlake University
2020-2025
Shanghai Institute of Organic Chemistry
2022
Institute of Biophysics
2016-2017
Chinese Academy of Sciences
2016-2017
University of Science and Technology of China
2017
University of Missouri
2017
University of Chinese Academy of Sciences
2016
Jinzhou Medical University
2014
Renal fibrosis is a common pathological feature and outcome of almost all chronic kidney diseases, it characterized by metabolic reprogramming toward aerobic glycolysis. Mesenchymal stem cell-derived exosomes (MSC-Exos) have been proposed as promising therapeutic approach for renal fibrosis. In this study, we investigated the effect MSC-Exos on glycolysis underlying mechanisms. We demonstrated that significantly ameliorated unilateral ureter obstruction (UUO)-induced inhibiting in tubular...
Heteromeric amino acid transporters (HATs) catalyze the transmembrane movement of acids, comprising two subunits, a heavy chain and light chain, linked by disulfide bridge. The b
Heteromeric amino acid transporters (HATs), including y + LAT1-4F2hc complex, are responsible for transporting acids across membranes, and mutations in LAT1 cause lysinuric protein intolerance (LPI), a hereditary disorder characterized by defective cationic transport. The relationship between LPI specific has yet to be fully understood. In this study, we the function of complex mammalian cells determined cryo-EM structures human two distinct conformations: apo state an inward-open...
Abstract Sodium-Potassium Pump (Na + /K -ATPase, NKA) is an ion pump that generates electrochemical gradient of sodium and potassium ions across the plasma membrane by hydrolyzing ATP. During each Post-Albers cycle, NKA exchanges three cytoplasmic for two extracellular through alternating changes between E1 E2 states. Hitherto, several steps remained unknown during complete working cycle NKA. Here, we report cryo-electron microscopy (cryo-EM) structures recombinant human (hNKA) in distinct...
The soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex is composed of three neuronal proteins VAMP2, Syntaxin and SNAP25, which plays a core role during the process membrane fusion. zipping assembly SNARE releases energies drives vesicle cell into close proximity. In this study, we use all-atom molecular dynamics simulations to probe its unzipping in context at atomistic details. Our results indicated that NTD domain relatively more stable than CTD,...
Density functional theory (DFT) and correlated molecular orbital electronic structure calculations were used to study the Al + CO2 → AlO CO reaction on ground-state potential-energy surface (PES). Geometries optimized using DFT (M11/jun-cc-pV(Q+d)Z) more accurate energies obtained composite Weizmann-1 with Brueckner doubles (W1BD). The results comprise most complete, systematic characterization of date are based consistent application high-level methods for all stationary points identified....