A5111755875- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Additive Manufacturing and 3D Printing Technologies
- Bone Tissue Engineering Materials
- Membrane Separation Technologies
- Ovarian function and disorders
- Advanced Optical Network Technologies
- Software-Defined Networks and 5G
- Wound Healing and Treatments
- Congenital heart defects research
- Interconnection Networks and Systems
- Metabolism and Genetic Disorders
- Air Quality and Health Impacts
- Graphene and Nanomaterials Applications
- Concrete and Cement Materials Research
- Periodontal Regeneration and Treatments
- Ovarian cancer diagnosis and treatment
- Human Mobility and Location-Based Analysis
- Inhalation and Respiratory Drug Delivery
- Intravenous Infusion Technology and Safety
- Blind Source Separation Techniques
- Infection Control and Ventilation
- Membrane Separation and Gas Transport
- Cardiac Fibrosis and Remodeling
Southern University of Science and Technology
2025
Tsinghua University
2012-2024
Brigham and Women's Hospital
2024
Harvard University
2024
Institute of Engineering Thermophysics
2024
Chinese Academy of Sciences
2024
University of Chinese Academy of Sciences
2024
Sichuan University
2018-2023
West China Hospital of Sichuan University
2018-2023
Jilin University
2023
Advances in three-dimensional (3D) printing have enabled the direct assembly of cells and extracellular matrix materials to form vitro cellular models for 3D biology, study disease pathogenesis new drug discovery. In this study, we report a method Hela gelatin/alginate/fibrinogen hydrogels construct cervical tumor models. Cell proliferation, metalloproteinase (MMP) protein expression chemoresistance were measured printed compared with conventional 2D planar culture Over 90% cell viability...
Recurrent inflammation, intense bacterial infections, and inadequate blood vessel growth make diabetic wounds non-healing. Under pathological environment, cellular functions are also inhibited. In this paper, we developed a novel in situ injectable photo-crosslinking hydrogel embedded with heterojunction Ag@ZnO nanoparticles (NPs) which exhibit dual-channel synergistic ion release reactive oxygen species (ROS) production for anti-bacteria cutaneous regeneration. This platform can be...
Brain tissue engineering has now emerged as one of the most promising treatments for traumatic brain injury. In this article, two groups three-dimensional (3D) hydrogel structures composed gelatin and gelatin/hyaluronan have been formed using our 3D cell assembly technique in vivo study rats, order to investigate their effects reparation injury central nervous system (CNS). The were implanted into cortical defects created rat brains, abilities improve reconstruction then evaluated. After 4,...
The ability to fabricate three-dimensional (3D) thick vascularized myocardial tissue could enable scientific and technological advances in engineering drug screening, may accelerate its application myocardium repair. In this study, we developed a novel biomimetic scaffold integrating oriented micro-pores with branched channel networks mimic the anisotropy vasculature of native myocardium. were fabricated using an 'Oriented Thermally Induced Phase Separation (OTIPS)' technique, network was...
Constructing in vitro drug models with a higher degree of bionics is considered to be an important approach improve the effectiveness existing screening models. 3D printing, co-culture and microfluidics are methods that commonly used. This study combined advantages three methods. A microfluidic model controllable hepatoma cluster size was constructed, applied pharmacodynamic tests new anti-CD147 monoclonal antibody, Metuzumab. In phase cell preparation, cells were found proliferate faster...
The characteristics of the matrix (composition, structure, mechanical properties) and external culture environment (pulsatile perfusion, physical stimulation) heart are important in engineering functional myocardial tissue. This study reports on development chitosan-collagen scaffolds with micropores an array parallel channels (~ 200 µm diameter) that were specifically designed for cardiac tissue using stimulation. to have similar structural properties those native matrix. Scaffolds seeded...
Heteromeric amino acid transporters (HATs), including y + LAT1-4F2hc complex, are responsible for transporting acids across membranes, and mutations in LAT1 cause lysinuric protein intolerance (LPI), a hereditary disorder characterized by defective cationic transport. The relationship between LPI specific has yet to be fully understood. In this study, we the function of complex mammalian cells determined cryo-EM structures human two distinct conformations: apo state an inward-open...
Complex name constitution plus huge-sized routing table makes wire speed lookup a challenging task in Named Data Networking. To overcome this challenge, we propose two techniques to significantly up the process. First, look prefixes an order based on distribution of prefix length forwarding table, which can find longest match much faster than linear search current prototype CCNx. The be dynamically adjusted as changes. Second, new near-perfect hash data structure that combines many small...
Magnetic resonance imaging (MRI) remains the standard modality for local staging of gynecological malignancies, but it has several limitations, especially when differentiating a cancer limited to endometrium from invading superficial myometrium.To explore 1.5 T diffusion tensor (DTI) in assessing myometrial infiltration by endometrial carcinoma.We analyzed sensitivity apparent coefficient (ADC) versus fractional anisotropy (FA) diagnosing compared DCE-MRI and T2-weighted (T2WI) 35 patients...
It has been proved that the laser cladding particulate reinforced metal-based composite coating is of great benefit to industrial applications, owing its superior properties such as wear resistance, corrosion and metallurgical bond with a base metal. also well-known railway switch can easily get damaged due abominable conditions high speed heavy haul in rail-wheel mechanical system, it cause quite huge loss every year. So, significance increase resistance steel. In this study, Fe-based...
Cardiac diseases have become the leading cause of death worldwide. Developing efficient strategies to treat such is great urgency. Stem cell-based regeneration medicine offers a novel approach for heart repair. However, low retention and poor survival rate engrafted cells limit its applications. Nanomaterials shown potentials in addressing above issues due nanoparticles-bio interactions. Therefore, combining nanomaterials stem cell therapy interest significance Herein, we provide...
Exposure to particulate contaminants can cause serious adverse health effects. Deposition on the facial mucosa is an important path of exposure, but it difficult conduct direct dose measurement real human subjects. In this study, we propose in vitro method assess administered doses micron-sized particles eyes and lips which computed tomographic scanning three-dimensional printing were used create a model that includes face, oropharynx, trachea, first five generations bronchi, lung volume....
As the network infrastructure has been consuming more and power, various schemes have proposed to improve power efficiency of devices. Many put links sleep when idle wake them up needed. A presumption in these schemes, though, is that router's line cards can be waken very quickly. However, through systematic measurement a major vendor's high-end routers, we find it takes minutes get card ready under current design. To address this issue, propose new design 1) keeps host processor standby,...
As the network infrastructure has been consuming more and power, various schemes have proposed to improve power efficiency of devices. Many put links sleep when idle wake them up needed. A presumption in these schemes, though, is that router's line cards can be waken quickly. However, through systematic measurement a major vender's high-end router, we find it takes minutes get card ready under current implementation. To address this issue, propose new design (1) keeps host processor always...
Abstract Engineering of biomimetic tissue implants provides an opportunity for repairing volumetric muscle loss (VML), beyond a tissue’s innate repair capacity. Here, we present thick, suturable, and pre-vascularized 3D containing human induced pluripotent stem cell-derived myogenic precursor cells (hiPSC-MPCs), which can differentiate into skeletal while maintaining self-renewing pool. The formation contractile myotubes millimeter-long fibers from hiPSC-MPCs is achieved in chemically,...
Abstract In this study, we generated self-assembly cardiac organoids (COs) from human pluripotent stem cells by dual-phase modulation of Wnt/β-catenin pathway, utilizing CHIR99021 and IWR-1-endo. The resulting COs exhibited a diverse array cardiac-specific cell lineages, cavity-like structures demonstrated the capacity spontaneous beating vascularization in vitro . We further employed these complex functional to replicate conditions akin myocardial infarction SARS-CoV-2 induced fibrosis....