A5052977026- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Surgical Sutures and Adhesives
- Intestinal and Peritoneal Adhesions
- Hernia repair and management
- Electrohydrodynamics and Fluid Dynamics
- Acute Kidney Injury Research
- Cardiac Structural Anomalies and Repair
- Metalloenzymes and iron-sulfur proteins
- Conducting polymers and applications
- Angiogenesis and VEGF in Cancer
- biodegradable polymer synthesis and properties
- Tuberous Sclerosis Complex Research
- Dental materials and restorations
- Graphene and Nanomaterials Applications
- SARS-CoV-2 detection and testing
- Renal Diseases and Glomerulopathies
- SARS-CoV-2 and COVID-19 Research
- RNA Interference and Gene Delivery
- Chronic Kidney Disease and Diabetes
- Muscle Physiology and Disorders
- Hemostasis and retained surgical items
- Nanomaterials for catalytic reactions
- Innovative Microfluidic and Catalytic Techniques Innovation
Brigham and Women's Hospital
2017-2024
Harvard University
2017-2024
Massachusetts Institute of Technology
2017-2022
Innovation Research Center
2017-2021
Huazhong University of Science and Technology
2020-2021
Union Hospital
2016-2021
Harvard–MIT Division of Health Sciences and Technology
2017-2020
IIT@MIT
2020
A highly elastic and adhesive photocrosslinkable surgical sealant using a modified human protein controls liquid leakages without the need for suturing.
The engineering of multifunctional biomaterials using a facile sustainable methodology that follows the principles green chemistry is still largely unexplored but would be very beneficial to world. Here, employment catalytic reactions in combination with biomass-derived starting materials design promote development eco-friendly technologies and materials. Herein, we disclose two cycles (combined catalysis) comprising oxidative decarboxylation quinone-catechol redox catalysis for lignin-based...
Abstract Bioengineering strategies for the fabrication of implantable lymphoid structures mimicking lymph nodes (LNs) and tertiary (TLS) could amplify adaptive immune response therapeutic applications such as cancer immunotherapy. No method to date has resulted in consistent formation high endothelial venules (HEVs), which is specialized vasculature responsible naïve T cell recruitment education both LNs TLS. Here orthogonal induced differentiation human pluripotent stem cells carrying a...
More than 90% of surgical patients develop postoperative adhesions, and the incidence hospital re-admissions can be as high 20%. Current adhesion barriers present limited efficacy due to difficulties in application incompatibility with minimally invasive interventions. To solve this clinical limitation, we developed an injectable sprayable shear-thinning hydrogel barrier (STHB) composed silicate nanoplatelets poly(ethylene oxide). We optimized technology recover mechanical integrity after...
Abstract The engineering of multifunctional surgical bactericidal nanofibers with inherent suitable mechanical and biological properties, through facile cheap fabrication technology, is a great challenge. Moreover, hernia, which when organ pushed an opening in the muscle or adjacent tissue due to damage structure function, dire clinical challenge that currently needs surgery for recovery. Nevertheless, post-surgical hernia complications, like infection, fibrosis, adhesions, scaffold...
With the increasing volume of cardiovascular surgeries and rising adoption rate new methodologies that serve as a bridge to cardiac transplantation require multiple surgical interventions, formation postoperative intrapericardial adhesions has become challenging problem limits future procedures, causes serious complications, increases medical costs. To prevent this pathology, we developed nanotechnology-based self-healing drug delivery hydrogel barrier composed silicate nanodisks...
Background: The facile preparation of oxygen-generating microparticles (M) consisting Polycaprolactone (PCL), Pluronic F-127, and calcium peroxide (CPO) (PCL-F-CPO-M) fabricated through an electrospraying process is disclosed. biological study confirmed the positive impact from on cell growth with high viability. presented technology could work as a prominent tool for various tissue engineering biomedical applications. Methods: oxygen-generated processes were thoroughly characterization...
Abstract Engineering of biomimetic tissue implants provides an opportunity for repairing volumetric muscle loss (VML), beyond a tissue’s innate repair capacity. Here, we present thick, suturable, and pre-vascularized 3D containing human induced pluripotent stem cell-derived myogenic precursor cells (hiPSC-MPCs), which can differentiate into skeletal while maintaining self-renewing pool. The formation contractile myotubes millimeter-long fibers from hiPSC-MPCs is achieved in chemically,...