A5007739274- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Neuroscience and Neural Engineering
- Pluripotent Stem Cells Research
- Tissue Engineering and Regenerative Medicine
- Conducting polymers and applications
- Osteoarthritis Treatment and Mechanisms
- Additive Manufacturing and 3D Printing Technologies
- Single-cell and spatial transcriptomics
- Cell Image Analysis Techniques
- Graphene and Nanomaterials Applications
- Muscle Physiology and Disorders
- Bone Tissue Engineering Materials
- Gene Regulatory Network Analysis
- Anesthesia and Neurotoxicity Research
- Advanced Chemical Sensor Technologies
- Planarian Biology and Electrostimulation
- Advanced biosensing and bioanalysis techniques
- Cellular Mechanics and Interactions
- Olfactory and Sensory Function Studies
- Advanced Sensor and Energy Harvesting Materials
- Electrochemical sensors and biosensors
Brigham and Women's Hospital
2018-2024
Harvard University
2018-2024
Stevens Institute of Technology
2018-2021
Harvard–MIT Division of Health Sciences and Technology
2019
Massachusetts Institute of Technology
2019
Developing biomimetic cartilaginous tissues that support locomotion while maintaining chondrogenic behavior is a major challenge in the tissue engineering field. Specifically, locomotive forces demand with strong mechanical properties, chondrogenesis requires soft microenvironment. To address this challenge, 3D cartilage-like bioprinted using two biomaterials different properties: hard biomaterial to reflect macromechanical properties of native cartilage, and create end, (MPa order...
Abstract Advances in biomanufacturing techniques have opened the doors to recapitulate human sensory organs such as nose and ear vitro with adequate levels of functionality. Such advancements enabled simultaneous targeting two challenges engineered organs, especially nose: i) mechanically robust reconstruction nasal cartilage high precision ii) replication functionality: odor perception. Hybrid can be equipped remarkable capabilities augmented olfactory Herein, a proof‐of‐concept for an...
A crucial step in creating reliable vitro platforms for neural development and disorder studies is the reproduction of multicellular three-dimensional (3D) brain microenvironment capturing cell-cell interactions within model. The power self-organization diverse cell types into spheroids could be harnessed to study mechanisms underlying trajectory diseases. challenge current 3D organoid spheroid models grown petri-dishes lack control over cellular localization diversity. To overcome this...
Engineering three-dimensional (3D) sensible tissue constructs, along with the complex microarchitecture wiring of sensory nervous system, has been an ongoing challenge in engineering field. By combining 3D bioprinting and human pluripotent stem cell (hPSC) technologies, constructs could be engineered a rapid, precise, controllable manner to replicate microarchitectures mechanosensory functionalities native (e.g. response external stimuli). Here, we introduce biofabrication approach create...
Abstract Herein, we introduce a flexible, biocompatible, robust and conductive electrospun fiber mat as substrate for flexible stretchable electronic devices various biomedical applications. To impart the mats with electrical conductivity, poly(3,4‐ethylenedioxythiophene) (PEDOT), polymer, was interpenetrated into nitrile butadiene rubber (NBR) poly(ethylene glycol)dimethacrylate (PEGDM) crosslinked mats. The were fabricated tunable orientation, random aligned, displayed elastomeric...
Carbon nanotube (CNT)-based composite or hybrid materials have been broadly used for various biomedical applications such as microactuators, sensors, capacitors, and flexible electronic textiles because of their appealing physical electrical properties energy-storage functions. However, to enable application-based specific functionalities (e.g., sensing, responding, deformation) it is essential that smart stimulus-responsive elements be incorporated into the CNT-based materials. A pioneering...
Experimental models of the central nervous system (CNS) are imperative for developmental and pathophysiological studies neurological diseases. Among these models, three-dimensional (3D) induced pluripotent stem cell (iPSC)-derived brain organoid have been successful in mitigating some drawbacks 2D models; however, they plagued by high organoid-to-organoid variability, making it difficult to compare specific gene regulatory pathways across 3D organoids with those native brain. Single-cell RNA...
Biodegradable cellular and acellular scaffolds have great potential to regenerate damaged tissues or organs by creating a proper extracellular matrix (ECM) capable of recruiting endogenous cells support ingrowth. However, since hydrogel-based normally degrade through surface erosion, cell migration ingrowth into might be inhibited early in the implantation. This could result insufficient de novo tissue formation injured area. To address these challenges, continuous microsized strand-like...
Abstract Engineering of biomimetic tissue implants provides an opportunity for repairing volumetric muscle loss (VML), beyond a tissue’s innate repair capacity. Here, we present thick, suturable, and pre-vascularized 3D containing human induced pluripotent stem cell-derived myogenic precursor cells (hiPSC-MPCs), which can differentiate into skeletal while maintaining self-renewing pool. The formation contractile myotubes millimeter-long fibers from hiPSC-MPCs is achieved in chemically,...
In article number 1906330, Jeroen Leijten, Su Ryon Shin, and co-workers develop 3D cartilage-like tissue through local bioprinting of mesenchymal stem cell spheroids laden with soft stimulating bioink within a mechanically robust hydrogel. This uncoupling the micro macro mechanical properties printed construct allows it to possess both chondrogenic microenvironment ability withstand loads.