A5014552541- Silk-based biomaterials and applications
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Bone Tissue Engineering Materials
- Osteoarthritis Treatment and Mechanisms
- Periodontal Regeneration and Treatments
- Biochemical and Structural Characterization
- Antimicrobial Peptides and Activities
- Wound Healing and Treatments
- Tissue Engineering and Regenerative Medicine
- Polymer Surface Interaction Studies
- Molecular Sensors and Ion Detection
- Knee injuries and reconstruction techniques
- Tendon Structure and Treatment
- Silkworms and Sericulture Research
- Surface Modification and Superhydrophobicity
- Advanced Sensor and Energy Harvesting Materials
- Nerve injury and regeneration
- X-ray Diffraction in Crystallography
- RNA Interference and Gene Delivery
- Crystallization and Solubility Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Luminescence and Fluorescent Materials
- Conducting polymers and applications
- Cell Adhesion Molecules Research
Indian Institute of Technology Guwahati
2016-2025
Bioengineering Center
2018
Tufts University
2010-2013
Indian Institute of Technology Kharagpur
2007-2012
Indian Institute of Technology Indore
2009
Biomaterials for bone tissue regeneration represent a major focus of orthopedic research. However, only handful polymeric biomaterials are utilized today because their failure to address critical issues like compressive strength load-bearing grafts. In this study development high (~13 MPa hydrated state) composite materials is reported, based on silk protein-protein interfacial bonding. Micron-sized fibers (10-600 µm) obtained utilizing alkali hydrolysis were used as reinforcement in compact...
An osteoarthritis pandemic has accelerated exploration of various biomaterials for cartilage reconstruction with a special emphasis on silk fibroin from mulberry (Bombyx mori) and non-mulberry (Antheraea assamensis) worms. Retention positive attributes the agarose standard nullification its negatives are central to current agarose/silk hydrogel design. In this study, hydrogels blended were fabricated evaluated in vitro two weeks cartilaginous tissue formation. The physicochemically...
Cartilage tissue is deprived of intrinsic self-regeneration capability; hence, its damage often progresses to a chronic condition which reduces the quality life. Toward fabrication functional substitutes, three-dimensional (3D) bioprinting has progressed vastly over last few decades. However, this progress challenged by difficulty in developing suitable bioink materials as most them require toxic chemical cross-linking. In study, our goal was develop cross-linker-free with optimal rheology...
Abstract Full‐thickness skin wounds, associated with deep burns or chronic wounds pose a major clinical problem. Herein, the development of in situ forming hydrogel using natural silk fibroin (SF) biomaterial for treating burn is reported. Blends SF solutions isolated from Bombyx mori and Antheraea assama show inherent self‐assembly between proteins lead to irreversible gelation at body temperature. Investigation mechanism reveals crosslinking due formation β‐sheet structures as examined by...
Spider silks are among the toughest known materials and thus provide models for renewable, biodegradable, sustainable biopolymers. However, entirety of their diversity still remains elusive, that exceed performance limits industrial fibers constantly being found. We obtained transcriptome assemblies from 1098 species spiders to comprehensively catalog silk gene sequences measured mechanical, thermal, structural, hydration properties dragline 446 species. The combination these protein...
Abstract Silk has attracted widespread attention due to its superlative material properties and promising applications. However, the determinants behind variations in among different types of silk are not well understood. We analysed physical samples from a variety silkmoth cocoons, including domesticated Bombyx mori varieties several species Saturniidae. Tensile deformation tests, thermal analyses investigations on crystalline structure orientation fibres were performed. The results showed...
Development of highly vascular dermal tissue-engineered skin substitutes with appropriate mechanical properties and cellular cues is in need for significant advancement the field reconstruction. Limitations have been imposed on natural biomaterials despite their superb biocompatibility hence, studies biomaterial blending ongoing. Herein, we investigated blends silk fibroin human hair-derived keratin as wound-healing substrates that promote enhanced fibroblast cell adhesion proliferation....
This paper describes a new source for fabricating high-strength, non-bioengineered silk gland fibroin 3D scaffolds from Indian tropical tasar silkworm, Antheraea mylitta using SDS dissolution. The were fabricated by freeze drying at different prefreezing temperatures pore size and porosity optimization. Superior mechanical properties with compressive strength in the range of 972 kPa observed. matrices degraded proteases within 28 d incubation. Biocompatibility was assessed feline fibroblast...
Developing biomimetic cartilaginous tissues that support locomotion while maintaining chondrogenic behavior is a major challenge in the tissue engineering field. Specifically, locomotive forces demand with strong mechanical properties, chondrogenesis requires soft microenvironment. To address this challenge, 3D cartilage-like bioprinted using two biomaterials different properties: hard biomaterial to reflect macromechanical properties of native cartilage, and create end, (MPa order...
Composite biomaterials as artificial bone graft materials are pushing the present frontiers of bioengineering. In this study, a biomimetic, osteoconductive tricomposite scaffold made hydroxyapatite (HA) embedded in non-mulberry Antheraea assama (A. assama) silk fibroin fibers and its solution is explored for osteogenic potential. Scaffolds were physico-chemically characterized morphology, porosity, secondary structure conformation, water retention ability, biodegradability, mechanical...
In recent times self-assembled micellar nanoparticles have been successfully employed in tissue engineering for targeted drug delivery applications. this review, silk sericin protein from non-mulberry Antheraea mylitta tropical tasar cocoons was blended with pluronic F-127 and F-87 the presence of solvents to achieve nanostructures capable carrying both hydrophilic (FITC-inulin) hydrophobic (anticancer paclitaxel) drugs. The fabricated were subsequently characterized their size distribution,...
Myocardial microenvironment plays a decisive role in guiding the function and fate of cardiomyocytes, engineering this extracellular niche holds great promise for cardiac tissue regeneration. Platforms utilizing hybrid hydrogels containing various types conductive nanoparticles have been critical tool constructing engineered tissues with outstanding mechanical integrity improved electrophysiological properties. However, there has no attempt to directly compare efficacy these decipher...