A5086388331- Biochemical effects in animals
- Iron oxide chemistry and applications
- Tryptophan and brain disorders
- Circadian rhythm and melatonin
- Acute Ischemic Stroke Management
- Arsenic contamination and mitigation
- Barrier Structure and Function Studies
- Intracranial Aneurysms: Treatment and Complications
- Infant Nutrition and Health
- Congenital heart defects research
- Cardiac Fibrosis and Remodeling
- Zebrafish Biomedical Research Applications
- Neurological Disease Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Tissue Engineering and Regenerative Medicine
- Mercury impact and mitigation studies
- Coronary Interventions and Diagnostics
- Biochemical Analysis and Sensing Techniques
- Diffusion and Search Dynamics
- Cancer-related cognitive impairment studies
- Alzheimer's disease research and treatments
- Optical Imaging and Spectroscopy Techniques
- Protein Hydrolysis and Bioactive Peptides
- Olfactory and Sensory Function Studies
- Neurosurgical Procedures and Complications
Sichuan University
2022-2024
West China Hospital of Sichuan University
2022-2024
North China Electric Power University
2023
State Key Laboratory of Biotherapy
2022-2023
Blood-brain barrier (BBB) disruption is a pivotal pathophysiological process in ischemic stroke. Although temporal changes BBB permeability during the acute phase have been widely studied, little known about chronic of cerebrovascular that may large impact on long-term outcome. Therefore, this study was aimed to measure cerebral vascular abnormalities using CT perfusion nine rhesus monkeys subjected transient middle artery occlusion (tMCAO) for ≥1 year (MCAO-1Y+). The level demonstrated by...
Anxiety disorders are the most common mental and, without proper treatment, may lead to severe conditions: e.g., somatic or permanent damage central nervous system. Although there drugs in clinical trials, this study focuses on exploring efficacy of nutrients treating these diseases. We built different zebrafish models and screened several nutrient combinations for their antianxiety, antioxidant, neuro-protecting, memory-improving activities. Our results showed that (e.g., Walnut Peptides +...
Introduction Anxiety disorders continue to prevail as the most prevalent cluster of mental following COVID-19 pandemic, exhibiting substantial detrimental effects on individuals’ overall well-being and functioning. Even after a search spanning over decade for novel anxiolytic compounds, none have been approved, resulting in current medications being effective only specific subset patients. Consequently, researchers are investigating everyday nutrients potential alternatives conventional...
Abstract Background and Purpose Carotid artery stenosis is a major risk factor for ischemic stroke. Despite carotid stenting, in‐stent restenosis (ISR) remains challenging. Pigs serve as an ideal ISR model. This study aims to establish novel porcine model of using open‐loop closed‐loop stents assess with optical coherence tomography (OCT) histopathology, comparing incidence vascular response between stent types. Methods Twelve adult male Bama miniature pigs underwent stenting either or...
Abstract In this study, we generated self-assembly cardiac organoids (COs) from human pluripotent stem cells by dual-phase modulation of Wnt/β-catenin pathway, utilizing CHIR99021 and IWR-1-endo. The resulting COs exhibited a diverse array cardiac-specific cell lineages, cavity-like structures demonstrated the capacity spontaneous beating vascularization in vitro . We further employed these complex functional to replicate conditions akin myocardial infarction SARS-CoV-2 induced fibrosis....
Introduction Brain development during infancy is crucial for later health and development. Although Milk Fat Globule Membrane (MFGM) has been demonstrated to enhance brain development, further investigation needed determine the optimal dose. Methods In this study, 80 piglets aged 2 days were randomly assigned four groups: Control group, MFGM-L (1.74 g MFGM per 100 diet), MFGM-M (4.64 MFGM-H (6.09 diet). Daily body weight milk intake of recorded until 31 postnatal. Learning memory abilities...
Blood-brain barrier (BBB) disruption is pivotal in the pathophysiological process of ischemic stroke and often measured rodent studies. Traditionally, BBB permeability increase determined by measuring cerebral leakage certain dyes such as Evans Blue or sodium fluorescein (NaFL). However, due to special processing samples for measurement, they cannot be used afterward determining other essential parameters infarction volume. Therefore, using different batches animals assessing volume typical....
Introduction: Anxiety and depression are recognized as adaptive responses to external stressors in organisms. Current methods for evaluating anxiety rodents both burdensome stressful. The objective of this investigation is explore a simplified methodology identifying stress-induced stress-free states, well levels, by analyzing the movement patterns rodents. Methods: To address issue, we utilized Levy statistics examine stressed compared them non-stressed controls. We employed two-dimensional...
Abstract Brain aneurysm ruptured subarachnoid hemorrhages (SAH) are extremely rare except in humans. This study described a SAH caused by anterior communication artery and concurrent myocardial infarction, along with pneumonia intestinal obstruction rhesus monkey, which is rather animal experiments.