A5102981853- Gut microbiota and health
- Probiotics and Fermented Foods
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Microbial Metabolites in Food Biotechnology
- Genetics, Aging, and Longevity in Model Organisms
- Osteoarthritis Treatment and Mechanisms
- Protein Hydrolysis and Bioactive Peptides
- Circadian rhythm and melatonin
- Microbial Metabolism and Applications
- Phytoestrogen effects and research
- MicroRNA in disease regulation
- Food Quality and Safety Studies
- Field-Flow Fractionation Techniques
- Advanced Glycation End Products research
- Listeria monocytogenes in Food Safety
- Knee injuries and reconstruction techniques
- Ginseng Biological Effects and Applications
- Biochemical effects in animals
- Plant Virus Research Studies
- RNA Interference and Gene Delivery
- Bacterial biofilms and quorum sensing
- Extracellular vesicles in disease
- Tea Polyphenols and Effects
Korea Food Research Institute
2022-2025
Fraunhofer Institute for Environmental, Safety and Energy Technology UMSICHT
2023
Lotte Fine Chemical (South Korea)
2018-2022
University of Cincinnati Medical Center
2022
University of Cincinnati
2020-2022
Jeonbuk Agricultural Research & Extension Services
2022
Chung-Ang University
2021
EuBiologics (South Korea)
2021
Jeonbuk National University
2013-2020
Bugok National Hospital
2016-2017
Left-right (LR) asymmetry (handedness, chirality) is a well-conserved biological property of critical importance to normal development. Changes in orientation the LR axis due genetic or environmental factors can lead malformations and disease. While organs whole organisms has been extensively studied, little known about at cellular multicellular levels. Here we show that cultivation cell populations on micropatterns with defined boundaries reveals intrinsic chirality be readily determined by...
Abstract Ginger ( Zingiber officinale Roscoe) has been used widely as a food spice and an herbal medicine. In particular, its gingerol‐related components have reported to possess antimicrobial antifungal properties, well several pharmaceutical properties. However, the effective ginger constituents that inhibit growth of oral bacteria associated with periodontitis in human cavity not elucidated. This study revealed ethanol n ‐hexane extracts exhibited antibacterial activities against three...
Tissue engineering provides unique opportunities for regenerating diseased or damaged tissues using cells obtained from tissue biopsies. engineered grafts can also be used as high fidelity models to probe cellular and molecular interactions underlying developmental processes. In this study, we co-cultured human umbilical vein endothelial (HUVECs) mesenchymal stem (MSCs) under various environmental conditions elicit synergistic leading the colocalized development of capillary-like bone-like...
Here, we examined the functionality of Lactobacillus fermentum strain JDFM216, a newly isolated probiotic bacterium, using Caenorhabditis elegans model. We determined bacterial colonization in intestinal tract C. by plate counting and transmission electron microscopy survival solid killing assay. In addition, employed DNA microarray analysis, quantitative real time-polymerase chain reaction, immunoblotting assays to explore health-promoting pathways induced bacteria elegans. Initially, found...
Abstract Increasing evidence indicates that alterations in gut microbiota are associated with mammalian development and physiology. The has been proposed as an essential player metabolic diseases including brain health. This study aimed to determine the impact of probiotics on degenerative changes cognitive behavior. Assessment various behavioral physiological functions was performed using Y-maze tests, wheel running accelerated rotarod balance beam forced swimming tests (FSTs), adult mice...
Circadian rhythms regulate diverse aspects of gastrointestinal physiology ranging from the composition microbiota to motility. However, development intestinal circadian clock and detailed mechanisms regulating intestine remain largely unknown. In this report, we show that both pluripotent stem cell-derived human organoids engrafted into mice patient-derived enteroids possess demonstrate phase-dependent necrotic cell death responses Clostridium difficile toxin B (TcdB). Intriguingly, mouse...
Resistant starch serves as a prebiotic in the large intestine, aiding maintenance of healthy intestinal environment and mitigating associated chronic illnesses. This study aimed to investigate impact resistant starch-enriched brown rice (RBR) on health functionality. We assessed changes concentration, structural alterations, branch chain length distribution throughout digestion process using an vitro model. The efficacy RBR was evaluated through analyses its potential, effects microbiota,...
Acorus gramineus (sweet flag), a medicinal plant, especially its rhizome, shows strong antioxidant and anti-inflammatory effects; however, efficacy in treating intestinal inflammation obesity is still unexplored. In this study, we investigated the prebiotic activity of sweet flag rhizome extract (SRE) preventive effects against high-fat diet (HFD)-induced colonic inflammation. The was assessed based on scores four probiotic strains. SRE administered to mice fed an HFD for 8 weeks, obesity-...
The characteristics of the matrix (composition, structure, mechanical properties) and external culture environment (pulsatile perfusion, physical stimulation) heart are important in engineering functional myocardial tissue. This study reports on development chitosan-collagen scaffolds with micropores an array parallel channels (~ 200 µm diameter) that were specifically designed for cardiac tissue using stimulation. to have similar structural properties those native matrix. Scaffolds seeded...
In this study, we investigated potentially probiotic Bacillus licheniformis strains isolated from traditional Korean food sources for ability to enhance longevity using the nematode Caenorhabditis elegans as a simple in vivo animal model. We first whether B. were capable of modulating lifespan C. elegans. Among tested strains, preconditioning with four significantly enhanced Unexpectedly, plate counting and transmission electron microscopy (TEM) results indicated that not more highly...
Gellan gum (GG) is an anionic polysaccharide used as additive in the food industry. However, effect of GG on gut microbiota regulation and nonalcoholic fatty liver disease (NAFLD) has not yet been investigated. In vitro fermentation experiments have demonstrated that promoted growth probiotic strains such Lactiplantibacillus rhamnosus Bifidobacterium bifidum, producing metabolites beneficial to health. mice, reduced hepatic triglyceride content, serum biomarkers, body fat mass weight gain...
Fusarium graminearum causes a serious scab disease of small grains in Korea. The nucleotide sequence the genomic RNA double-stranded (dsRNA) virus, virus-DK21 (FgV-DK21), from F. strain DK21, which is associated with hypovirulence graminearum, was determined and compared to genome sequences other mycoviruses, including Cryponectria hypoviruses. FgV-DK21 dsRNA consists 6,624 nucleotides, excluding 3'-terminal poly(A) tail. viral has 53- 46-nucleotide 5' 3' untranslated regions (UTRs),...