A5021281236- Liver Disease Diagnosis and Treatment
- Robotic Path Planning Algorithms
- Robotics and Sensor-Based Localization
- Neuroblastoma Research and Treatments
- Evacuation and Crowd Dynamics
- Adipose Tissue and Metabolism
- Phytochemicals and Antioxidant Activities
- Drug-Induced Hepatotoxicity and Protection
- Nuclear Structure and Function
- Optimization and Search Problems
- Cell Image Analysis Techniques
- Peroxisome Proliferator-Activated Receptors
- RNA Interference and Gene Delivery
- RNA Research and Splicing
- Mobile Crowdsensing and Crowdsourcing
- Adipokines, Inflammation, and Metabolic Diseases
- Genomics and Chromatin Dynamics
- Advanced Vision and Imaging
- Advanced Electron Microscopy Techniques and Applications
- Distributed Control Multi-Agent Systems
- Alcohol Consumption and Health Effects
- Natural Antidiabetic Agents Studies
- Image Processing Techniques and Applications
- Essential Oils and Antimicrobial Activity
- Edible Oils Quality and Analysis
Italian Institute of Technology
2021-2025
University of Genoa
2016-2024
Honda (United States)
2021-2024
University of Rome Tor Vergata
2024
University of L'Aquila
2024
California Institute of Technology
2017-2023
University of Groningen
2017
University of Illinois Urbana-Champaign
2016
Robot navigation in crowded public spaces is a complex task that requires addressing variety of engineering and human factors challenges. These challenges have motivated great amount research resulting important developments for the fields robotics human-robot interaction over past three decades. Despite significant progress massive recent interest, we observe number remaining prohibit seamless deployment autonomous robots environments. In this survey article, organize existing into set...
To investigate in vitro the therapeutic effect and mechanisms of silybin a cellular model hepatic steatosis.Rat hepatoma FaO cells were loaded with lipids by exposure to 0.75 mmol/L oleate/palmitate for 3 h mimic liver steatosis. Then, steatotic incubated 24 different concentrations (25 100 μmol/L) as phytosome complex vitamin E. The effects on lipid accumulation metabolism, indices oxidative stress evaluated absorption fluorescence microscopy, quantitative real-time PCR, Western blot,...
Robot navigation in crowded public spaces is a complex task that requires addressing variety of engineering and human factors challenges. These challenges have motivated great amount research resulting important developments for the fields robotics human-robot interaction over past three decades. Despite significant progress massive recent interest, we observe number remaining prohibit seamless deployment autonomous robots pedestrian environments. In this survey article, organize existing...
Laser scanning microscopy (LSM) serves as the backbone of numerous advanced imaging techniques, with confocal laser (CLSM) being a pivotal tool in life sciences research. However, its effective resolution is often compromised by optical aberrations, common challenge all systems. While adaptive optics (AO) can correct these current methods face significant limitations. Aberration estimation, which central to any AO approach, typically requires specialized hardware or prolonged sample...
Non-alcoholic fatty liver disease (NAFLD) is a major cause of liver-related morbidity and mortality. Oxidative stress release pro-inflammatory cytokines, such as tumor necrosis factor α (TNFα), are consequences hepatic lipid overload, which can contribute to progression NAFLD non-alcoholic steatohepatitis (NASH). Also, mitochondria involved in the pathogenesis for their role metabolism. Definitive treatments NAFLD/NASH lacking so far. Silybin, extract milk thistle seeds, has previously shown...
Plants and plant extracts are a relevant source of bioactive compounds widely employed as functional foods. In the Mediterranean area, shrub Sarcopoterium spinosum is traditionally used an herbal medicine for weight loss diabetes treatment. Inflammation protective mechanism involved in development many pathological conditions, including cardiovascular diseases. The present study aimed to investigate vitro antioxidant cytoprotective properties ethanolic extract from S. fruits (SEE) cellular...
Overconsumption of fats and sugars is a major cause development non‑alcoholic fatty liver disease (NAFLD). The main objectives the present study were to explore pathways sustaining interfering metabolic effects excess fructose acids in hepatocytes, clarify mechanisms through which nutraceutical silybin rescues functional alterations that are associated with NALFD progression. Cultured hepatocytes exposed acids, alone or combination, induce different grades steatosis vitro. Cell viability,...
In this work, we propose a robust network-in-the-loop control system for autonomous navigation and landing of an Unmanned-Aerial-Vehicle (UAV). To estimate the UAV's absolute pose, develop deep neural network (DNN) architecture visual-inertial odometry, which provides alternative to traditional methods. We first evaluate accuracy estimation by comparing prediction our model approaches on publicly available EuRoC MAV dataset. The results indicate clear improvement in pose up 25% over...
In the brain, polyamines are mainly synthesized in neurons, but preferentially accumulated astrocytes, and proposed to be involved neurodegenerative/neuroinflammatory disorders neuron injury. A transgenic mouse overexpressing spermine oxidase (SMOX, which specifically oxidizes spermine) neocortex neurons (Dach-SMOX mouse) was proved a model of increased susceptibility excitotoxic injury.To investigate possible alterations synapse functioning Dach-SMOX mouse, both cerebrocortical nerve...
Thyme-like plants including Thymbra spicata L. are widely used as food and folk medicinal remedies in the Mediterranean area. This study aimed to explore vitro antitumor potential of polyphenol-enriched extracts from aerial parts T. spicata. The ethanolic extract significantly inhibited proliferation different human tumor cell lines, without significant effects on non-neoplastic cells. A deeper investigation molecular mechanism sustaining activity was carried breast cancer cells MCF-7...
S-adenosylmethionine (SAMe) is an endogenous methyl donor derived from ATP and methionine that has pleiotropic functions. Most SAMe synthetized consumed in the liver, where it acts as main methylating agent protection against free radical toxicity. Previous studies have shown administration of a supernutrient exerted many beneficial effects various tissues, mainly liver. In present study, we aimed to clarify direct on fatty acid-induced steatosis oxidative stress hepatic endothelial cells....
In this paper, we develop a novel algorithm for spacecraft trajectory planning in an environment cluttered with many geometrically-fixed obstacles. The Spherical Expansion and Sequential Convex Programming (SE-SCP) first uses spherical-expansion-based sampling to explore the workspace. Once path is found from start position goal position, generates locally optimal within homotopy class using sequential convex programming. If number of samples tends infinity, then SE-SCP converges globally...
Obesity is a major risk factor for metabolic dysfunction such as non-alcoholic fatty liver disease (NAFLD). The NAFLD spectrum ranges from simple steatosis, to steatohepatitis, fibrosis, and cirrhosis. aim of this study characterize the grade steatosis being associated with overnutrition obesity, both at level single hepatocyte whole liver, correlate it hepatocyte/liver stiffness dysfunction. For in vivo study, 60 subjects were enrolled grouped based on stage steatosis/fibrosis according...
Hepatic steatosis is often a consequence of obesity. Adipose tissue an important endocrine regulator metabolic homeostasis in the body. In obesity, adipocytes become hypertrophic and develop inflammatory phenotype, altering panel secreted adipokines. Moreover, excess fatty acids are, part, released by delivered to liver. These multiple pathways adipose-liver crosstalk contribute development progression liver disease: TNFα induces hepatocyte dysfunction, circulating promotes hepatic...
Obesity is associated with fatty liver disease. Available therapies show modest efficacy, and nutraceuticals good effectiveness safety are largely investigated. We focused on five natural compounds, three plant phenolic compounds (carvacrol, rosmarinic acid, silybin), two thyroid hormones (T2: 3,5-diiodo-l-thyronine; T3: 3,5,3'-triiodo-L-thyronine) as comparison, to assess their beneficial effects cellular models of hepatosteatosis adipogenesis. All ameliorated the lipid accumulation...
Sarcopoterium spinosum (L.) Spach is a Rosaceae shrub employed in the folk medicine Eastern Mediterranean basin. The previous few studies have focused on S. roots, while fruits been poorly investigated. present study aims to assess biological properties of collected Lebanon and subjected ethanolic, water or boiling extraction. extracts were compared for phenol flavonoid contents, vitro radical scavenging ability. ethanolic extract (SEE) was selected characterized by high-performance liquid...