A5090245377- Neuroscience and Neuropharmacology Research
- Air Quality Monitoring and Forecasting
- Alzheimer's disease research and treatments
- Indoor Air Quality and Microbial Exposure
- Neuroinflammation and Neurodegeneration Mechanisms
- Air Quality and Health Impacts
- Photoreceptor and optogenetics research
- Photochromic and Fluorescence Chemistry
- Prion Diseases and Protein Misfolding
- RNA regulation and disease
- Neuroendocrine regulation and behavior
- Ion channel regulation and function
- Epilepsy research and treatment
- Cholinesterase and Neurodegenerative Diseases
- Receptor Mechanisms and Signaling
- Computational Drug Discovery Methods
- Atmospheric chemistry and aerosols
- Neuroscience of respiration and sleep
- Muscle metabolism and nutrition
- Neurological diseases and metabolism
- Atmospheric and Environmental Gas Dynamics
- Neurotransmitter Receptor Influence on Behavior
- Nicotinic Acetylcholine Receptors Study
- Lipid Membrane Structure and Behavior
- Memory and Neural Mechanisms
University of Genoa
2016-2025
University of Naples Federico II
2012
Neuroblastoma (NB) is a pediatric cancer characterized by remarkable cell heterogeneity within the tumor nodules. Here, we demonstrate that synthesis of pol III-transcribed noncoding (nc) RNA (NDM29) strongly restricts NB development promoting differentiation, drop malignancy processes, and dramatic reduction initiating (TIC) fraction in population. Notably, overexpression NDM29 also confers to malignant cells an unpredicted susceptibility effects antiblastic drugs used therapy. Altogether,...
A set of twenty-five thioxanthene-9-one and xanthene-9-one derivatives, that were previously shown to inhibit cholinesterases (ChEs) amyloid β (Aβ40) aggregation, evaluated for the inhibition tau protein aggregation. All compounds exhibited a good activity, eight them (5-8, 10, 14, 15 20) shared comparable low micromolar inhibitory potency versus Aβ40 aggregation human acetylcholinesterase (AChE), while inhibiting butyrylcholinesterase (BChE) even at submicromolar concentration. Compound 20...
The atmosphere harbors a great diversity of microorganisms. Among them, some taxa bacteria, such as Methylobacterium species are abundant and recurring members the viable fraction (Amato et al., 2017; Woo Yamamoto, 2020). These include non-obligate light-users, we postulate that this function could be linked with their prevalence survival capacity in atmosphere. alternative use light to generate biochemical energy (ATP) through photoheterotrophy anoxygenic photosynthesis is known enhance...
Airborne biological particles, such as pollen, fungi, bacteria, viruses, and plant or animal detritus, are known bioaerosols. Understanding bioaerosols' behavior, especially their reaction to pollutants atmospheric conditions, is crucial for addressing environmental health issues related air quality. Such complex investigations can benefit from experiments in controlled but realistic environments, the Atmospheric Simulation Chamber facility ChAMBRe (Chamber Aerosol Modeling Bio-aerosol...
Abstract. Atmospheric simulation chambers are exploratory platforms used to study various atmospheric processes at realistic but controlled conditions. We describe here a new facility specifically designed for the research on bio-aerosol as well protocols produce, inject, expose and collect bio-aerosols. ChAMBRe (Chamber Aerosol Modelling Bio-aerosol Research) is installed Physics Department of University Genoa, Italy, it node EUROCHAMP-2020 consortium. The chamber made stainless steel with...
Two series of naphthoquinone and anthraquinone derivatives decorated with an aromatic/heteroaromatic chain have been synthesized evaluated as potential promiscuous agents capable targeting different factors playing a key role in Alzheimer's disease (AD) pathogenesis. On the basis vitro biological profiling, most them exhibited significant ability to inhibit amyloid aggregation, PHF6 tau sequence acetylcholinesterase (AChE), monoamine oxidase (MAO) B. In particular, 2 resulted one best...
The ability of oxytocin (OT) to interact with the dopaminergic system through facilitatory D2-OT receptor (OTR) receptor-receptor interaction in limbic is increasingly considered play roles social or emotional behavior, and suggested serve as a potential therapeutic target. Although astrocytes modulatory effects OT dopamine central nervous are well recognized, possibility D2-OTR has been neglected. In purified astrocyte processes from adult rat striatum, we assessed OTR D2 expression by...
Previous studies have demonstrated that the knockdown or knockout of three Na(+)/Ca(2+) exchanger (NCX) isoforms, NCX1, NCX2, and NCX3, worsens ischemic brain damage. This suggests activation these antiporters exerts a neuroprotective action against stroke However, drugs able to increase activity NCXs are not yet available. We here succeeded in synthesizing new compound, named neurounina-1 (7-nitro-5-phenyl-1-(pyrrolidin-1-ylmethyl)-1H-benzo[e][1,4]diazepin-2(3H)-one), provided with an high...
Roles of astrocytes in the modulatory effects oxytocin (OT) central nervous system are increasingly considered. Nevertheless, OT on gliotransmitter release have been neglected.In purified astrocyte processes from adult rat striatum, we assessed receptor (OTR) and adenosine A2A expression by confocal analysis. The receptors activation glutamate were evaluated; A2A-OTR heteromerization was co-immunoprecipitation PLA. Structure possible heterodimer estimated a bioinformatic approach.Both...
Alternative splicing generates protein isoforms that are conditionally or differentially expressed in specific tissues. The discovery of factors control alternative might clarify the molecular basis biological and pathological processes. We found IL1-α−dependent up-regulation 38A, a small ribonucleic acid (RNA) polymerase III–transcribed RNA, drives synthesis an alternatively spliced form potassium channel–interacting (KCNIP4). KCNIP4 isoform cannot interact with γ-secretase complex,...
The protein ataxin-3 (ATX3) triggers an amyloid-related neurodegenerative disease when its polyglutamine stretch is expanded beyond a critical threshold. We formerly demonstrated that the polyphenol epigallocatechin-3-gallate (EGCG) could redirect amyloid aggregation of full-length, ATX3 (ATX3-Q55) towards non-toxic, soluble, SDS-resistant aggregates. Here, we have characterized other related phenol compounds, although smaller in size, i.e. (-)-epigallocatechin gallate (EGC), and gallic acid...
Increasing evidence indicates that photobiomodulation, based on tissue irradiation with photons in the red to near-infrared spectrum, may be an effective therapeutic approach central nervous system disorders. Although functionality has been shown affected by animal models, as well preliminary healthy subjects or patients neuropsychiatric disorders, mechanisms involved photobiomodulation effects have not yet clarified. We previously observed could stimulate glutamate release. Here, we...
The nine-member CLC gene family of Cl