A5081706553- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Metabolomics and Mass Spectrometry Studies
- Cancer Immunotherapy and Biomarkers
- Cell death mechanisms and regulation
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Prostate Cancer Treatment and Research
- Cancer, Stress, Anesthesia, and Immune Response
- Monoclonal and Polyclonal Antibodies Research
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2024
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2024
Vita-Salute San Raffaele University
2021-2024
SAIC-GM (China)
2020
Humanitas University
2020
Tumor-associated macrophages (TAMs) are correlated with the progression of prostatic adenocarcinoma (PCa). The mechanistic basis this correlation and therapeutic strategies to target TAMs in PCa remain poorly defined. Here, single-cell RNA sequencing was used profile transcriptional landscape human PCa, leading identification a subset characterized by dysregulation pathways associated lipid metabolism. This correlates positively shorter disease-free survival is an accumulation lipids that...
Reversing CD8+ T cell dysfunction is crucial in treating chronic hepatitis B virus (HBV) infection, yet specific molecular targets remain unclear. Our study analyzed co-signaling receptors during hepatocellular priming and traced the trajectory fate of dysfunctional HBV-specific cells. Early on, these cells upregulate PD-1, CTLA-4, LAG-3, OX40, 4-1BB, ICOS. While blocking co-inhibitory had minimal effect, activating 4-1BB OX40 converted them into antiviral effectors. Prolonged stimulation...
376 Background: Genetic lesions that drive prostate cancer (PCa) development are able to modify the immune response and tumor infiltrating subsets, resulting in progression. We investigated profile of microenvironment PCa by high dimensional single cell analysis. Methods: conducted an profiling study based on integrated RNA sequencing multiparametric flow cytometry order dissect landscape PCa. CD45+ cells tumoral adjacent non tissues were isolated from patients with who underwent software...
You have accessJournal of UrologyProstate Cancer: Basic Research & Pathophysiology III (PD59)1 Apr 2020PD59-02 HIGH DIMENSIONAL PROFILING OF THE IMMUNE MICROENVIRONMENT IN PROSTATE CANCER REVEALED NOVEL TUMOR-DRIVEN ALTERATIONS INFILTRATING SUBSETS Massimo Lazzeri*, Michela Masetti, Federica Portale, Roberta Carriero, Bianca Partini, Andrea Ponzetta, Sebastien Jaillon, Piergiuseppe Colombo, Grazia Elefante, Alberto Saita, Paolo Casale, Clelia Peano, Kunderfranco, Javier Cibella, Giorgio...