A5019512564- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- RNA modifications and cancer
- Hemoglobinopathies and Related Disorders
- MicroRNA in disease regulation
- Chronic Lymphocytic Leukemia Research
- Cancer-related molecular mechanisms research
- Protein Degradation and Inhibitors
- Neutropenia and Cancer Infections
- Chronic Myeloid Leukemia Treatments
- Epigenetics and DNA Methylation
- Autoimmune and Inflammatory Disorders Research
- Bioinformatics and Genomic Networks
- Blood groups and transfusion
- Neonatal Health and Biochemistry
- Mesenchymal stem cell research
- RNA Research and Splicing
- Cancer-related Molecular Pathways
- Immune Cell Function and Interaction
- Genomics and Chromatin Dynamics
- Polyomavirus and related diseases
- Complement system in diseases
- Platelet Disorders and Treatments
- Protein Tyrosine Phosphatases
Fortis Memorial Research Institute
2019-2024
New York University
2019-2024
Vellore Institute of Technology University
2023-2024
NYU Langone Health
2023
Apollo Hospitals
2022-2023
Narayana Health
2016-2020
Bose Institute
2014-2019
For efficient clearance of Mycobacterium tuberculosis (Mtb), macrophages tilt towards M1 polarization leading to the activation transcription factors associated with production antibacterial effector molecules such as nitric oxide (NO) and proinflammatory cytokines interleukin 1 β (IL-1β) tumor necrosis factor α (TNF-α). At same time, resolution inflammation is M2 increased arginase IL-10. The transcriptional post-transcriptional mechanisms that govern balance between polarization,...
Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides, which show evidence of pervasive transcription and participate in a plethora cellular regulatory processes. Although several have been functionally annotated as lncRNAs within the genome, not all proven to fulfill criteria for functional regulator further analyses be done order include them cohort. LncRNAs being classified reclassified an ongoing annotation process, challenge is fraught with ambiguity, newer evidences...
Abstract Resveratrol, a trans -stilbene polyphenolic compound and its synthetic analogs are widely used bioactive molecules due to their remarkable chemo-preventive potential. Here, we have identified novel compound, Z-DAN-11 ((Z)-3-(3, 4-dimethoxyphenyl)-2-(3, 4, 5-trimethoxyphenyl) acrylonitrile) which shows efficacy in blocking tumor growth progression both vitro vivo. inhibits proliferation of cancer cells through microtubule depolymerization that induced G2/M arrest consequently leads...
Despite significant efforts to improve therapies for acute myeloid leukemia (AML), clinical outcomes remain poor. Understanding the mechanisms that regulate development and maintenance of leukemic stem cells (LSCs) is important reveal new therapeutic opportunities. We have identified CD97, a member adhesion class G protein–coupled receptors (GPCRs), as frequently up-regulated antigen on AML blasts critical regulator blast function. High levels CD97 correlate with poor prognosis, silencing...
// Jizhong Liu 1 , Ashish Masurekar Suzanne Johnson Sohini Chakraborty 2 John Griffiths 3 Duncan Smith Seema Alexander Clare Dempsey Catriona Parker Stephanie Harrison Yaoyong Li 4 Crispin Miller Yujun Di Zhumur Ghosh Shekhar Krishnan 1, 5 Vaskar Saha Children's Cancer Group, Institute of Science, Manchester Academic Health Sciences Centre, University Manchester, United Kingdom Bioinformatics Bose Institute, Kolkata, India Mass Spectrometry Service, Research UK Applied Computational Biology...
Acute myeloid leukemia (AML) is a common and aggressive hematological malignancy. Acquisition of heterogeneous genetic aberrations epigenetic dysregulation lead to the transformation hematopoietic stem cells (HSC) into leukemic (LSC), which subsequently gives rise immature blast phenotype. LSCs are responsible for disease relapse as current chemotherapeutic regimens not able completely eradicate these cellular sub-populations. Therefore, it critical improve upon existing knowledge LSC...
Abstract Macrophages play an important role in the establishment of infection by intracellular pathogens. Mycobacterium tuberculosis is known to inhibit apoptosis and downregulate immune responses host cells using various strategies, including activation peroxisome proliferator‐activated receptor (PPAR)γ. Mannose‐capped lipoarabinomannan (ManLAM) one bacterial effectors that plays a subversion immunity PPARγ. Here, we have used unbiased global gene expression profiling approach understand (...
Metastasis is a major breast cancer hallmark due to which tumor cells tend relocate regional or distant organs from their organ of origin. This study aimed decipher the interaction among 113 differentially expressed genes, interacting non-coding RNAs and drugs (614 miRNAs, 220 lncRNAs 3241 drugs) associated with metastasis in cancer. For an extensive understanding genetic interactions diseased state, backbone gene co-expression network was constructed. Further, mRNA-miRNA-lncRNA-drug...
Aberrant expression of microRNAs (miRNAs) is associated with tumour progression, extracellular matrix remodelling, and cell proliferation. miRNAs modulate host gene during infection by pathogens such as Helicobacter pylori, which varying degrees gastric pathology. In order to gain insight into the regulation H. pylori epithelial cells its likely downstream consequences, we analysed transcriptomes miRnomes AGS infected pylori. silico analysis miRNA–mRNA interactions suggested that...
Infection of macrophages by Mycobacterium tuberculosis elicits an immune response that clears the bacterium. However, bacterium is able to subvert innate response. Differential expression transcription factors (TFs) central dynamic balance this interaction. Among other functions, TFs regulate production antibacterial agents such as nitric oxide, pro-inflammatory cytokines and neutral lipids which are stored in lipid bodies (LBs) favour bacterial survival. Here, we demonstrate TF activating...