A5031388723- Dietary Effects on Health
- Epigenetics and DNA Methylation
- Traumatic Brain Injury and Neurovascular Disturbances
- RNA modifications and cancer
- Alzheimer's disease research and treatments
- Circadian rhythm and melatonin
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Traumatic Brain Injury Research
- Biochemical effects in animals
- Mitochondrial Function and Pathology
- RNA and protein synthesis mechanisms
- Heme Oxygenase-1 and Carbon Monoxide
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Folate and B Vitamins Research
- Neurological Disease Mechanisms and Treatments
- Moyamoya disease diagnosis and treatment
- Stress Responses and Cortisol
- Adipokines, Inflammation, and Metabolic Diseases
- Histone Deacetylase Inhibitors Research
- Lipid Membrane Structure and Behavior
- S100 Proteins and Annexins
- Cell death mechanisms and regulation
University of Wisconsin–Madison
2020-2025
Neurological Surgery
2020-2025
Highland Community College - Illinois
2025
National Institute of Technology Calicut
2016-2019
Vanderbilt University
1965
Preconditioning by intermittent fasting is linked to improved cognition and motor function, enhanced recovery after stroke. Although the duration of was shown elicit different levels neuroprotection ischemic stroke, impact time with respect circadian cycles remains unexplored.
FTO (fat mass and obesity-associated protein) demethylates
Intermittent fasting (IF) is known to induce significant ischemic tolerance. Diet a major proponent of gut microbiota, and microbial dysbiosis plays role in post-stroke brain damage. Hence, we currently evaluated whether IF-mediated tolerance mediated by microbiota. Additionally, circadian cycle modulate post-ischemic outcomes, thus further if microbiota would be influenced prophylactic IF during the inactive phase (fasting daytime; IIF) or active nighttime; AIF). The AIF, but not IIF,...
We previously showed that knockdown or deletion of Fos downstream transcript (FosDT; a stroke-induced brain-specific long noncoding RNA) is neuroprotective. presently tested the therapeutic potential FosDT siRNA in rodents subjected to transient middle cerebral artery occlusion (MCAO) using Stroke Treatment Academic Industry Roundtable criteria, including sex, age, species, and comorbidity. (IV) given at 30 min reperfusion significantly improved motor function recovery (rotarod test, beam...
The complex pathophysiology of post-traumatic brain damage might need a polypharmacological strategy with combination drugs that target multiple, synergistic mechanisms. We currently tested apocynin (curtails formation reactive oxygen species), tert-butylhydroquinone (promotes disposal and salubrinal (prevents endoplasmic reticulum stress) following moderate traumatic injury (TBI) induced by controlled cortical impact in adult mice. Adult mice both sexes treated the above tri-combo showed...
Epigenetic mechanisms have been shown to play a major role in the progression of stroke pathophysiology. The ten eleven translocases (TETs) are enzymes involved generating DNA hydroxymethylcytosine (5hmC), brain enriched epigenetic modification that is associated with transcriptional activation and neuroprotection. We previously TET3 isoform may be promoting endogenous neuroprotective pathways following injury. In current study, we investigated activity after by examining functional...