A5086986631- Neuroinflammation and Neurodegeneration Mechanisms
- Herpesvirus Infections and Treatments
- interferon and immune responses
- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Viral gastroenteritis research and epidemiology
- Immune Response and Inflammation
- Mosquito-borne diseases and control
- Alzheimer's disease research and treatments
- Viral Infections and Vectors
- Virus-based gene therapy research
- Inflammasome and immune disorders
- Cholesterol and Lipid Metabolism
- Autophagy in Disease and Therapy
- Infectious Encephalopathies and Encephalitis
- Kawasaki Disease and Coronary Complications
- Receptor Mechanisms and Signaling
- Influenza Virus Research Studies
- Cytomegalovirus and herpesvirus research
- Autoimmune and Inflammatory Disorders Research
Institut National de la Recherche Scientifique
2024
Université Laval
2019-2023
Wilfrid Laurier University
2019
Centre hospitalier universitaire de Québec
2019
The role of a signaling pathway through macrophage colony-stimulating factor (MCSF) and its receptor, 1 receptor (CSF1R), during experimental herpes simplex virus (HSV-1) encephalitis (HSE) was studied by two different approaches. First, we evaluated the effect stimulation MCSF/CSF1R axis before infection. Exogenous MCSF (40 μg/kg body weight intraperitoneally [i.p.]) administered once daily to BALB/c mice on days 4 2 intranasal infection with 2,500 PFU HSV-1. treatment significantly...
Microglia participate in the immune response upon central nervous system (CNS) infections. However, role of these cells during herpes simplex encephalitis (HSE) has not been fully characterized. We sought to identify different microglia/microglia-like and describe potential mechanisms signaling pathways involved HSE.The transcriptional CD11b+ cells, including was investigated using single-cell RNA sequencing (scRNA-seq) on isolated from ventral posterolateral nucleus (VPL)-enriched thalamic...
Abstract Background Zika virus (ZIKV) has been associated with several neurological complications in adult patients. Methods We used a mouse model deficient TRIF and IPS-1 adaptor proteins, which are involved type I interferon production, to study the role of microglia during brain infection by ZIKV. Young mice were infected intravenously contemporary ZIKV strain PRVABC59 (1 × 10 5 PFUs/100 µL). Results Infected did not present overt clinical signs disease nor body weight loss compared...
NOD-like receptor protein 3 (NLRP3) inflammasome activation triggers caspase-1 activation-induced maturation of interleukin (IL)-1β and IL-18 therefore is important for the development host defense against various RNA viral diseases. However, implication this complex in human metapneumovirus (HMPV) disease has not been fully studied. Herein, we report that NLRP3 plays a detrimental role during HMPV infection because inhibition protected mice from mortality reduced weight loss inflammation...
Human metapneumovirus (HMPV) is a major pediatric respiratory pathogen with currently no specific treatment or licensed vaccine. Different strategies to prevent this infection have been evaluated, including live-attenuated vaccines (LAV) based on SH and/or G protein deletions. This approach showed promising outcomes but has not evaluated further using different viral strains. In that regard, we previously HMPV strains harbor distinct in vitro fusogenic and vivo pathogenic phenotypes,...
The prolonged treatment of immunosuppressed (IS) individuals with anti-influenza monotherapies may lead to the emergence drug-resistant variants. Herein, we evaluated oseltamivir and polymerase inhibitors combinations against influenza A/H3N2 infections in an IS mouse model. Mice were cyclophosphamide infected 3 × 103 PFU a mouse-adapted A/Switzerland/9715293/2013 (H3N2) virus. Forty-eight hours post-infection, animals started oseltamivir, favipiravir or baloxavir marboxil (BXM) as single...
Abstract Human metapneumovirus (HMPV) is a major pediatric respiratory pathogen with currently no specific treatment or licensed vaccine. Different strategies to prevent this infection have been evaluated, including live-attenuated vaccines (LAV) based on SH and/or G protein deletions. This approach showed promising outcomes but has not evaluated further using different viral strains. In that regard, we previously HMPV strains harbor distinct in vitro fusogenic and vivo pathogenic...
Abstract Herpes simplex virus 1 (HSV-1) is responsible for herpes encephalitis (HSE), associated with a 70% mortality rate in the absence of treatment. Despite intravenous treatment acyclovir, remains significant, highlighting need new anti-herpetic agents. Herein, we describe novel neurovirulent recombinant HSV-1 (rHSV-1), expressing fluorescent tdTomato and Gaussia luciferase (Gluc) enzyme, generated by Clustered regularly interspaced short palindromic repeats (CRISPR)—CRISPR-associated...