A5008571164- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Ophthalmology and Visual Impairment Studies
- Glaucoma and retinal disorders
- Ocular Surface and Contact Lens
- Tissue Engineering and Regenerative Medicine
- Retinal Diseases and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Ocular Disorders and Treatments
- Advanced Optical Imaging Technologies
Eye & ENT Hospital of Fudan University
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
Shanghai Clinical Research Center
2023-2025
Shanghai Eye Disease Prevention & Treatment Center
2023-2025
Fudan University
2023-2024
Shanghai Jiao Tong University
2023
Shanghai First People's Hospital
2023
Creative Commons
2023
National Natural Science Foundation of China
2023
Shanghai Municipal Commission of Health and Family Planning
2023
To investigate the long-term safety and efficacy of using keratorefractive lenticule extraction (KLEx)-derived corneal stromal lenticules preserved in nutrient capsules for treatment diseases. Eye ENT Hospital Fudan University. Observational study. Ten eyes 10 patients with diseases (6 males, 4 females, age 38.10 ± 9.11 years, ) were treated phototherapeutic keratectomy combined epikeratophakia or intrastromal keratoplasty KLEx-derived lenticules. Corneal which used transplantation was...
Abstract The corneal lenticules extracted from small incision lenticule extraction (SMILE) can be used as an optional transplantation material. However, it cannot for deep anterior lamellar keratoplasty due to its thickness limitations. In this study, oxidized chondroitin sulfate (O─CS) containing ─SO 3 − groups twisted with generation 4.0 polyamidoamine dendrimers (G4 PAMAM) which contain −NH 2 + via electrostatic entanglement form a cohesive module, is applicable in suture‐free of cornea,...
The purpose of this study was to investigate the ex vivo and in biomechanical characteristic cornea myopic eyes.
Abstract Background This study assessed the agreement of ocular parameters patients with myopia measured using Colombo intraocular lens (IOL) 2 and IOLMaster 700. Methods Eighty (male, 22; average age, 29.14 ± 7.36 years) (159 eyes) were included in this May 2023. The participants’ axial length (AXL), central corneal thickness (CCT), (LT), white-to-white distance (WTW), front flat (K1), steep (K2), mean (Km) keratometry, astigmatism (Astig), J0 vector, J45 vector 700 IOL 2. measurements from...
This study aimed to investigate the underlying pathophysiology of high myopia by analyzing proteome human corneal stromal lenticule samples obtained through small incision extraction (SMILE). A total thirty-two patients who underwent SMILE were included in study. Label-free quantitative proteomic analysis was performed on samples, equally representing (n = 10) and low groups. The identified profiled proteomes analyzed using silico tools explore biological characteristics differentially...
Purpose: To evaluate changes of hydroxyproline concentration and its influencing factors small incision lenticule extraction (SMILE)-derived corneal stromal lenticules with different preservation methods. Methods: A total 390 195 patients were derived from SMILE surgeries. Thirty the classified as fresh (control) group, rest randomly evenly divided stored in anhydrous glycerol, silicone oil, Optisol, cryopreservation for 1 day, week, or month. assay kit (ab222941, Abcam) was used to measure...
To compare the characteristics of corneal thickness measurements among RTVue, Casia-2, and Pentacam in patients with mild-to-moderate keratoconus.We recruited 46 eyes diagnosed keratoconus at our hospital between January March 2022. The central (CCT) thinnest (TCT) were measured using two optical coherence tomography (OCT) instruments (RTVue Casia-2) more conventional Pentacam. Differences correlations CCTs TCTs, based on device influencing factors, explored.The highly consistent groups (p =...
<title>Abstract</title> Background This study assessed the agreement of anterior segment parameters patients with myopia measured using 2 swept-source optical coherent biometry devices: Colombo intraocular lens (IOL) and IOL Master 700. Methods Eighty (male/female, 22/58; average age, 29.11 ± 7.77 years) (159 eyes) were included in this May 2023. All participants underwent measurements 700 to obtain axial length (AXL), central corneal thickness (CCT), (LT), white-to-white (WTW), front flat...
Abstract Purpose Autostereoscopic displays have become increasingly common, but their impact on ocular dimensions remains unknown. We sought to identify changes in the crystalline lens induced by autostereoscopic three‐dimensional (3D) viewing. Methods Forty young adults (age: 22.6 ± 2.0 years, male/female: 15/25) were consecutively enrolled and randomly divided into two groups (3D two‐dimensional [2D] viewing groups) watch a 30‐min movie clip displayed 3D or 2D mode tablet computer. The...
Phototherapeutic keratectomy (PTK) combined with epikeratophakia (EP) using double lenticules through small-incision lenticule extraction (SMILE) after late recurrence was used in a patient Reis-Bückler corneal dystrophy (RBCD) who underwent bilateral PTK 9.5 years previously. Opacity recurred at 4 years, + EP being performed SMILE-derived lenticules, and 5.5 an uncorrected visual acuity of 20/100 disrupted counting fingers the right left eyes. eye on original were performed. Manifest...
Abstract Purpose To analyze the corneal morphology of keratoconus using CASIA2, Sirius, and Pentacam. Methods Patients diagnosed with at Eye ENT Hospital Fudan University (January-November 2022) were included. Corneal refraction, astigmatism, thickness, elevation parameters measured The measurement differences, agreement, sensitivity specificity each instrument for diagnosing was evaluated. P < 0.05 considered statistically significant. Results A total 61 eyes 48 healthy myopic Ks Kf...
Abstract This study aimed to investigate the awareness of high and pathological myopia among patients with myopia. A cross‐sectional multicenter survey involving both physicians was conducted between February April 2021. The outpatient education status, doctors' expectations toward patient education, patients' high/pathological myopia, their access relevant knowledge were inquired, proportions including assessed. In total, involved 6975 from 161 medical institutions in China. prevalence...
To investigate the relationship between corneal tomographic or biomechanical parameters and risk of keratoconus in very asymmetric ectasia (VAE).This retrospective case-control single-centre study included patients with VAE normal controls. The group had clinical one eye topography (VAE-NT) fellow eye; VAE-NT eyes were selected for analysis. control was from refractive surgery candidates; right enrolled. Scheimpflug-based tomography (Pentacam) assessment (Corvis ST) performed. Univariate...
Abstract Purpose To explore the characteristics of RTVue, Casia-2, and Pentacam instruments for measuring corneal thickness in patients with mild to moderate keratoconus. Methods We recruited diagnosed keratoconus at our hospital from January March 2022; 46 eyes (46 patients) were enrolled (35 men [76.09%], 30 right [65.22%], mean age 24.3 ± 6.2 years). Central (CCT) thinnest (TCT) measured using two optical coherence tomography (OCT) (RTVue Casia-2) more conventional Pentacam. Then,...