A5101604643- Adipose Tissue and Metabolism
- Total Knee Arthroplasty Outcomes
- Pulmonary Hypertension Research and Treatments
- Child and Adolescent Psychosocial and Emotional Development
- Orthopaedic implants and arthroplasty
- Neonatal Respiratory Health Research
- Hip disorders and treatments
- Voice and Speech Disorders
- Pregnancy-related medical research
- Mitochondrial Function and Pathology
- Stress Responses and Cortisol
- Pancreatic and Hepatic Oncology Research
- Tryptophan and brain disorders
- Stuttering Research and Treatment
- Transplantation: Methods and Outcomes
- Mechanical Circulatory Support Devices
- Psychosomatic Disorders and Their Treatments
- Dysphagia Assessment and Management
- Cancer Genomics and Diagnostics
- Endometriosis Research and Treatment
- Child Abuse and Trauma
- Tracheal and airway disorders
- Fatty Acid Research and Health
- Respiratory and Cough-Related Research
- Natural Antidiabetic Agents Studies
Assistance Publique – Hôpitaux de Paris
2024
The University of Texas Rio Grande Valley
2022-2024
The University of Texas Southwestern Medical Center
2024
Baylor Scott & White Health
2024
Hôpital Necker-Enfants Malades
2024
Columbia University
2023
University College London
2022
Occidental College
2019
California State University Los Angeles
2013-2014
Marqués de Valdecilla University Hospital
2012
Early detection of pancreatic cancer has been shown to improve patient survival rates. However, effective early tools detect do not currently exist. The Avantect Pancreatic Cancer Test, leveraging the 5-hydroxymethylation [5-hydroxymethylcytosine (5hmC)] signatures in cell-free DNA, was developed and analytically validated address this unmet need. We report a comprehensive analytical validation study encompassing precision, sample stability, limit detection, interfering substance studies,...
Gene mutations of insulin-like 3 (INSL3) peptide or its G protein-coupled receptor RXFP2 (relaxin family 2) lead to cryptorchidism. The role INSL3 in adult females is less known, although expression has been described female reproductive organs. Caveolin-1 (CAV1), the main component caveoli cell membrane invaginations, shown play an important epithelial organization and stromal-epithelial interactions. We created a null allele Cav1 mice by deleting second exon through embryonic stem...
Abstract Background As total hip arthroplasty (THA) indications continue to expand and longevity increases, it is important understand the outcomes in different patient populations. Younger, more active patients are electing proceed with THA differing severity of disease. We aimed investigate reported outcome measures (PROMs) who underwent less severe radiographic arthrosis. Methods Pre- post-operative PROMs data (joint-space width, Tonnis grade) for undergoing between 9/16/2016 10/21/2021...
Abstract Background Children with advanced pulmonary disease due to cystic fibrosis (CF) are at risk of acute respiratory failure exacerbations leading their admission pediatric intensive care units (PICU). The objectives this study were determine short and medium-term outcomes children CF admitted PICU for exacerbation identify prognosis factors. Methods This retrospective monocentric included patients less than 18 years old the a French university hospital between 2000 2020. Cox...
Adolescent-onset depression is a prevalent and debilitating condition commonly associated with treatment refractory non-response to first-line antidepressants. There are, however, no objective tests determine who may or not respond As depressed adolescents are especially vulnerable the lifelong consequences of ineffectively-treated depression, it critical identify neurobiological predictors in this population. Here, we describe scientific rationale protocol for Teen Inflammation Glutamate...
Type‐2 diabetes (T2D) leads to an imbalance of mitochondrial fusion/fission events. Epicatechin is a cocoa plant flavanol that has shown cardioprotective effects in the ischemia reperfusion setting. Our objectives are observe protective epicatechin and vitro vivo models type 2 diabetes. In , C2C12 myoblasts were cultured glucolipotoxicity treatment (GLT) for 3 days high glucose (~33 mM) fatty acids (0.6 media, ± epicatechin. rat model included controls, sham (1 mg/kg/day), mg/kg/day). T2D...
Type 2 Diabetes (T2D) mitochondrial effects include imbalanced dynamic events of fusion, fission, and autophagy. The flavanol epicatechin has been previously observed to provide cardioprotection in the setting ischemia‐reperfusion by reducing inflammation ROS production. Our objectives are observe protective T2D via vitro vivo models. In vitro, C2C12 myoblasts were cultured glucolipotoxicity treatment (GLT) for 3 days high glucose (~33 mM) fatty acids (0.6 media, ± epicatechin. rat model...
Abstract Background: Total hip arthroplasty (THA) for the treatment of dysplasia, which disproportionately impacts younger population, has been shown to be an effective intervention restore functionality and improve quality life. However, it is unclear whether these outcomes can just as beneficial in treating dysplasia when presents older patients. Therefore, we sought investigate compare pre-and postoperative THA adults those with end-stage osteoarthritis (OA). Methods: A prospectively...
Patients with type 2 diabetes (T2D) have a heightened risk of developing heart failure due to mitochondrial abnormalities and sporadic cardiac energy metabolism. The main objective this project is determine KATP channel dysfunction UCP‐2 expression relative each other utilizing an in vivo rat model T2D. Administration epicatehin, cocoa flavanol, was tested for cardioprotection Results demonstrated that diabetic animals had significant increases body weight blood glucose levels, while EPI...
Gestational Hypoxia is a common prenatal stress caused by high altitude living, smoking, and other disorders. Such hypoxic insult can cause abnormalities in lung development that result pulmonary hypertension the newborn. known to oxidative accentuate glycolysis adult tissues, effects which are intertwined with of various diseases. However, adaptive responses metabolism long term hypoxia (LTH) fetal vasculature not nearly as well understood. The current work tests hypothesis following...