A5067161558- Alzheimer's disease research and treatments
- Gestational Diabetes Research and Management
- Amyotrophic Lateral Sclerosis Research
- Pregnancy and preeclampsia studies
- Prion Diseases and Protein Misfolding
- Diabetes Treatment and Management
- MicroRNA in disease regulation
- Dementia and Cognitive Impairment Research
- Cerebrovascular and genetic disorders
- Metabolism, Diabetes, and Cancer
- Cholinesterase and Neurodegenerative Diseases
- Circular RNAs in diseases
- Diet and metabolism studies
- Birth, Development, and Health
- Neurological diseases and metabolism
- Thyroid Cancer Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Bariatric Surgery and Outcomes
- Adipokines, Inflammation, and Metabolic Diseases
- Nutritional Studies and Diet
- Extracellular vesicles in disease
- Thyroid and Parathyroid Surgery
- Pharmacology and Obesity Treatment
- Cancer, Lipids, and Metabolism
- Diabetes and associated disorders
Magna Graecia University
2018-2025
Azienda Ospedaliero Universitario Mater Domini
2023
BioAge (Italy)
2013-2022
Centers for Disease Control and Prevention
2017
National Institute of Health
2015
University of Turin
2010
University of Florence
2007-2010
Regione del Veneto
2008-2009
National Institute on Aging
2007
Texas Tech University
2007
BackgroundInsulin resistance in visceral adipose tissue (VAT), skeletal muscle and liver is a prominent feature of most patients with obesity. How this association arises remains poorly understood. The objective study was to demonstrate that the decrease insulin receptor (INSR) expression signaling VAT from obese individuals an early molecular manifestation might play crucial role cascade events leading systemic resistance.MethodsTo clarify INSR dysfunction obesity, we first measured samples...
Neuropsychiatric or behavioral and psychological symptoms of dementia (BPSD) represent a heterogeneous group non-cognitive that are virtually present in all patients during the course their disease. The aim this study is to examine prevalence natural history BPSD large cohort with variant frontotemporal (bvFTD) Alzheimer's disease (AD) three stages: (i) pre-T0 (before onset disease); (ii) T0 manifested (from 5 years); (iii) T1 advanced years onwards). Six hundred seventy-four clinical...
Introduction—The purpose of this study was to determine the relative impact modifiable and non-modifiable risk factors in development gestational diabetes mellitus (GDM), with a particular focus on maternal preconception body mass index (BMI) age, two important determinants insulin resistance. Understanding that contribute most current escalation GDM rates pregnant women could help inform prevention intervention strategies, particularly areas where female endocrine disorder has an elevated...
Patients with diabetes have been reported to enhanced susceptibility severe or fatal COVID-19 infections, including a high risk of being admitted intensive care units respiratory failure and septic complications. Given the global prevalence diabetes, affecting over 450 million people worldwide still on rise, emerging crisis poses serious threat an extremely large vulnerable population. However, broad heterogeneity complexity this dysmetabolic condition, reference etiologic mechanisms, degree...
Background: Liraglutide is the first glucagon-like peptide-1 receptor agonist (GLP-1 RA) based on human GLP-1 sequence, with potential weight loss benefits, approved for treatment of type 2 diabetes (T2D) mellitus. Herein, we aimed to assess 5-year effectiveness in management and glycometabolic control a Southern Italian cohort overweight/obese T2D patients, who were naïve RAs. Patients Methods: Forty overweight or obese patients treated at doses up 1.8 mg/day, combination one more oral...
Background . SGLT-2 (sodium-glucose cotransporter-2) inhibitors are a novel class of oral hypoglycemic agents for the management type 2 diabetes mellitus (T2DM). Herein, we aimed to assess long-term effectiveness and safety in Southern Italy population subjects affected by T2DM. Patients Methods 408 diabetic patients treated with one three currently available (dapagliflozin, empagliflozin, canagliflozin), either alone or combination other antidiabetic drugs, were retrospectively assessed at...
Objective: Recently, the role of circulating miRNAs as noninvasive biomarkers for identification and monitoring diabetes microvascular complications has emerged. Herein, we aimed to: identify differentially expressed in patients with without diabetic retinopathy (DR); examine their predictive value; understand pathogenic impact. Methods: Pooled serum samples from randomly selected matched type 2 diabetes, either or DR, were used initial plasma miRNA profiling. Validation most relevant was...
Aims and methods: The aim of this monocentric retrospective observational study was to evaluate the 18-month safety effectiveness GLP-1 receptor agonist (GLP-1 RA) dulaglutide (DU) 1.5 mg/once weekly as an add-on metformin (MET) or MET plus conventional insulin secretagogues in a cohort with excess body weight type 2 diabetes (T2D). Comparative efficacy versus liraglutide (LIRA) 1.2–1.8 daily sample naïve RAs, frequency matching for age, gender, T2D duration, degree glycemic impairment,...
Background: Thrombospondin-1 (TSP1) is a multimeric glycoprotein that increasingly recognized as mediator of metabolic, thrombotic, and inflammatory processes. Although TSP1 expression has been associated with adipose tissue dysfunction insulin resistance, the precise relationship obesity severity remains unclear. Endothelin-1 (ET1), another important regulator vascular homeostasis, may also contribute to obesity-related cardiometabolic risk, evidence suggesting sex-specific differences,...
<b>Background: </b> Frontotemporal dementia (FTD) in several 17q21-linked families was recently explained by truncating mutations the progranulin gene (<i>GRN</i>). <b>Objective: To determine frequency of <i>GRN</i> a cohort Caucasian patients with FTD without known genes. <b>Methods: </b><i>GRN</i> sequenced series 78 independent including 23 familial subjects. A different Calabrian dataset (109 normal control subjects and 96 patients) used to establish mutation. <b>Results: novel mutation...
Background—The first trimester combined test (FTCT) is an effective screening tool to estimate the risk of fetal aneuploidy. It obtained by combination maternal age, ultrasound nuchal translucency (NT) measurement, and serum markers free β-human chorionic gonadotropin (β-hCG) pregnancy-associated plasma protein A (PAPP-A). However, conflicting data have been reported about association FTCT, β-hCG, or PAPP-A with subsequent diagnosis gestational diabetes mellitus (GDM). Research design...
Screening strategies for gestational diabetes mellitus (GDM) earlier than 24-28 weeks of gestation should be considered to prevent adverse pregnancy outcomes. Nonetheless, there is uncertainty about which women would benefit most from early screening and offered with GDM. The Italian National Healthcare Service (NHS) recommendations on selective GDM at 16-18 are effective in preventing fetal macrosomia high-risk (HR) women, but the appropriateness timing effectiveness these medium- (MR)...
Nesfatin-1 is a new anorexigenic neuropeptide involved in the regulation of hunger/satiety, eating, and affective disorders. We aimed to investigate nesfatin-1 secretion vitro, murine adipose cells, human fat samples, as well assess link between circulating levels, NUCB2 Fat Mass Obesity Gene (FTO) polymorphisms, BMI, Eating Disorders (EDs), pathological behaviors. was evaluated both normoxic fully differentiated 3T3-L1 mouse adipocytes after incubation under hypoxic conditions for 24 h....
Background and aim-Alterations in circulating microRNA (miRNA) expression patterns are thought to be involved the early stages of prediabetes, as well progression overt type 2 diabetes mellitus (T2D) its vascular complications. However, most research findings conflicting, part due differences miRNA extraction normalization methods, study populations their selection. This cross-sectional seeks find new potentially useful biomarkers predict and/or diagnose T2D by investigating differential...
Large kindreds segregating familial Alzheimer disease (FAD) offer the opportunity of studying clinical variability as observed for presenilin 1 (PSEN1) mutations. Two early-onset FAD (EOFAD) Calabrian families with PSEN1 Met146Leu (ATG/CTG) mutation constitute a unique population descending from remote common ancestor. Recently, several other EOFAD same have been described worldwide.We searched founder in different geographic origins by genealogic and molecular analyses. We also investigated...