A5029058428- Chronic Kidney Disease and Diabetes
- Streptococcal Infections and Treatments
- Cancer Research and Treatments
- Advanced Glycation End Products research
- Oral microbiology and periodontitis research
- Virus-based gene therapy research
- Surgical site infection prevention
- Toxoplasma gondii Research Studies
- Antibiotic Resistance in Bacteria
- Case Reports on Hematomas
- E-commerce and Technology Innovations
- Tea Polyphenols and Effects
- Genetic and Kidney Cyst Diseases
- Structural Engineering and Vibration Analysis
- Cyclone Separators and Fluid Dynamics
- Renal Diseases and Glomerulopathies
- Teaching and Learning Programming
- Genetic Syndromes and Imprinting
- Aerosol Filtration and Electrostatic Precipitation
- Traditional Chinese Medicine Studies
- Rabies epidemiology and control
- CRISPR and Genetic Engineering
- Wnt/β-catenin signaling in development and cancer
- Erythropoietin and Anemia Treatment
- Heat shock proteins research
Huzhou University
2020-2024
Wenzhou Medical University
2023
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2023
Fujian Medical University
2016-2019
First Affiliated Hospital of Xiamen University
2014-2019
Jining Medical University
2012-2014
Affiliated Hospital of Jining Medical University
2012-2014
Xinzhou Teachers University
2011
Second Hospital of Shandong University
2007-2010
University of Antwerp
2009-2010
Abstract Background Currently, early diagnosis of diabetic nephropathy (DN) remains a major challenge. Thus, more investigations into new DN‐related biomarkers are needed. Methods We employed urinary proteomic approach fluorescence‐based difference gel electrophoresis (DIGE) and mass spectrometry to identify novel in urine samples, which were from type 2 diabetes patients with normoalbuminuria (DM group), microalbuminuria (DN1 macroalbuminuria (DN2 group) control group ( n = 8 each group)....
Klebsiella pneumoniae is an important cause of healthcare-associated infections worldwide. Selective pressure, the extensive use antibiotics, and conjugational transmission antibiotic resistance genes across bacterial species genera facilitate emergence multidrug-resistant (MDR) K. pneumoniae. Here, we examined occurrence, phenotypes genetic features MDR isolated from patients in intensive care units (ICUs) at First Affiliated Hospital Xiamen University Xiamen, China, January to December...
Identification of the risk predictor diabetic nephropathy (DN) remains a major challenge currently. Thus, proteomic approaches to identify DN-related biomarker were performed.A comparative approach 2-D gel electrophoresis (2-DE) and mass spectrometry biomarkers in urine samples from 12 DN patients (six type 1 six 2 patients) healthy controls. Then, urinary level identified protein was detected by immunoturbidimetry assay 90 with normo-, micro- macroalbuminuria (n = 30 each group), controls.A...
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by aberrant T cell immune response. Diffuse proliferative nephritis (LN-IV) the most common, severe, and active form of nephritis. In this study, we investigated production Th1, Th2, Th17 cytokines in prediction LN-IV. ProcartaPlex multiplex immunoassays panels were used for detection serum profiling. Th1 (IL-18, IFN-γ, IL-12p70, IL-6, IL-17A) considerably expressed IV patients comparison to healthy control....
The knowledge on renal lymphatics is very limited and their importance often neglected in kidney transplantation surgery practice. Early papers demonstrated that acute ligation of hilar lymphatic ducts has a significant effect sodium excretion urine volume. However, the long-term effects function histology were not mentioned. Here we show time course lesions caused by vessels rats with or without contralateral nephrectomy.Animals divided into three groups: bilateral (2KL); one another...
Background Podocyte has inflammatory role in the development of diabetic nephropathy (DN). Mycophenolate mofetil (MMF), an anti-inflammatory agent, can suppress macrophage infiltration and reduce renal injury streptozotocin-induced rats. Angiotensin II receptor blocker (ARB), another protecting decrease podocyte loss DN. In this study, we detected expression levels monocyte chemoattractant protein-1 (MCP-1) nephrin to evaluate podocyte's reaction DN, observe compare effect MMF alone...
Erythropoietin (EPO) exerts (renal) tissue protective effects. Since it is unclear whether this a direct effect of EPO on the kidney or not, we investigated able to protect human renal tubular epithelial cells (hTECs) from oxidative stress and if so which pathways are involved. (epoetin delta) could hTECs against by dose-dependent inhibition reactive oxygen species formation. This possibly related membranous expression receptor (EPOR) since our data point EPOR as prerequisite for effect....
Abilities to tolerate environmental stresses and form biofilms on teeth surface are key virulence attributes of Streptococcus mutans , the primary causative agent human dental caries. ClpP, chief intracellular protease S. along with ATPases degrades altered proteins that might be toxic for bacteria, thus plays important roles in stress response. To further understand ClpP response a deficient strain was constructed used general tolerance, autolysis, mutacins production, assays. Here, we...
Green tea (GT) is one of the most popular beverages in world, which contains numerous polyphenols known as catechins. Because high rate GT consumption worldwide populations, even small effects on an individual basis could have a large public health impact. Therefore, more and researches focus for human health. To date, identified important modifier diabetes, lipid metabolism, some haematological indices. Based previous reports, this study tries to investigate green partial serological...
Operating system is the basic program for managing and controlling software hardware such as computers. It most that runs directly on bare metal. Since its birth in last century, it has been widely used personal computers, servers, smartphones other fields playing a vital role our lives, work, entertainment. Many universities different countries offer operating course, which provides relatively complete introduction to key functional modules of systems, from history systems implementation...
The embedded system is designed to perform specific computation tasks and usually in other devices. Unlike normal personal computer cloud server, it not for daily use but production environment with higher stability reliability demands various fields fixed functionalities, smaller size lower power consumption the of portable limit situations. course generally contains fundamental concepts, hardware architecture, software development, bootloader kernel etc. It a closely integrating theory...
Abstract Surgical site infection (SSI) is one of the most common complications posterior cervical surgery. It difficult to diagnose in early stage and may lead severe consequences such as wound dehiscence central nervous system infection. This retrospective study included patients who underwent surgery at The Second Affiliated Hospital Yuying Childrens Wenzhou Medical University from September 2018 June 2022. We employed several machine learning methods, gradient boosting (GB), random...
To investigate the changes of mean platelet volume (MPV), distribution width (PDW) and associated antibodies (PAIg) in children with acute immune thrombocytopenic purpura (aITP), to explore diagnostic value MPV, PDW, PAIg their combination for megakaryocyte dysmaturity aITP children.Plt count, MPV PDW 36 were measured by using Sysmex XN automatic blood cell analyzer, 33 acquired (ATP) without dysmaturity. The expression was detected flow cytometry, number classification megakaryocytes bone...
Objective To establish a patient-like human ovary carcinoma/spontaneous metastasis model using orthotopic transplantation of histologically intact tumor tissue. Methods An highly metastatic ovarian line (8910PM: serum carcinoma the ovary) previously grown substaneously was transplanted into ovicapaule microsurgery technique. Histologically pieces gained from implantation site were passaged between ovicapsules for four generations. Results All mice developed tumors and rates about 50 %. The...
Objective To discuss the incidence of chronic patients' anxiety and variation serum proteins fingerprints spectrum under anxiety.Methods 30 patients with diseases were randomly selected,SAS was used to evaluate on first day admission,and SELDI-TOF-MS second day.4 weeks psychological intervention implemented according SAS SELDI results,SAS score compared before after intervention.Results in (47.30 ±5.541) (33.73 ±7.887) intervention,and difference statistically significant (t =7.709,P ＜...