A5075341192- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Knee injuries and reconstruction techniques
- Osteoarthritis Treatment and Mechanisms
- Musculoskeletal synovial abnormalities and treatments
- Tendon Structure and Treatment
- Bone fractures and treatments
- Surgical Sutures and Adhesives
- Sarcoma Diagnosis and Treatment
- Hip and Femur Fractures
- Neurofibromatosis and Schwannoma Cases
- Shoulder Injury and Treatment
- Infectious Diseases and Tuberculosis
- Healthcare Policy and Management
- Multiple Myeloma Research and Treatments
- Elbow and Forearm Trauma Treatment
- Inflammatory mediators and NSAID effects
- Vitamin K Research Studies
- Immune cells in cancer
- Surgical site infection prevention
- Bariatric Surgery and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Hip disorders and treatments
- Dupuytren's Contracture and Treatments
LifeBridge Health
2022-2024
Sinai Hospital
2022-2024
Howard University Hospital
2019-2023
Mayo Clinic
2017-2022
Mayo Clinic in Arizona
2017-2020
John Wiley & Sons (United States)
2020
Mayo Clinic Hospital
2018
Mayo Clinic in Florida
2018
WinnMed
2018
Meharry Medical College
2013
Concurrent hip and spine pathologies can alter the biomechanics of spinopelvic mobility in primary total arthroplasty (THA). This study examines how differences pelvic orientation patients with fusions increase risk dislocation after THA.We identified 84 (97 THAs) between 1998 2015 who had undergone spinal fusion prior to THA. Patients were stratified into three groups depending on length lumbar whether or not sacrum was involved. Mean age 71 years (40 87) 54 (56%) female. The mean body mass...
Disruption of the extensor mechanism after total knee arthroplasty (TKA) is debilitating, and reported results numerous reconstructive options have varied. We previously early 13 patients who underwent reconstruction with use Marlex mesh. The purpose current study was to assess in a larger cohort patients, an emphasis on survivorship mesh, clinical results, complications.During period 2000 2015 at single tertiary care academic institution, 77 (77 TKAs) mesh for disruption (27 quadriceps...
ABSTRACT Arthrofibrosis is a common complication following total knee arthroplasty caused by pathologic fibroblast activation and excessive collagen deposition around synovial joint leading to debilitating loss of motion. Treatment options are limited because the mechanisms remain be characterized. Dysregulation inflammatory cascade may lead communication between myofibroblasts immune cells triggering tissue metaplasia, described clinically as arthrofibrosis. We explored novel use celecoxib...
Abstract The dense formation of abnormal scar tissue after total knee arthroplasty results in arthrofibrosis, an unfortunate sequela inflammation. purpose this study was to use a validated rabbit model assess the effects on surgically‐induced joint contractures two combined pharmacological interventions: celecoxib (CXB) loaded implanted collagen membrane, and subcutaneously (SQ) injected ketotifen. Thirty rabbits were randomly divided into five groups. first group received no intervention...
Aims Arthrofibrosis is a relatively common complication after joint injuries and surgery, particularly in the knee. The present study used previously described validated rabbit model to assess biomechanical, histopathological, molecular effects of mast cell stabilizer ketotifen on surgically induced knee contractures female rabbits. Methods A group 12 skeletally mature rabbits were randomly divided into two groups. One received subcutaneous (SQ) saline, second SQ injections. Biomechanical...
ABSTRACT Trauma, surgery, and other inflammatory conditions can lead to debilitating joint contractures. Adjunct pharmacologic modalities may permit clinical prevention treatment of recalcitrant We investigated the therapeutic potential rosiglitazone by intra‐articular delivery via oligo[poly(ethylene glycol)fumarate] (OPF) hydrogels in an established rabbit model arthrofibrosis. OPF loaded with were characterized for drug elution properties upon soaking minimum essential media (MEM) 10%...
Outcomes of current operative treatments for arthrofibrosis after total knee arthroplasty (TKA) are not consistently positive or predictable. Pharmacological in vivo studies have focused mostly on prevention arthrofibrosis. This study used a rabbit model to evaluate intra-articular (IA) effects celecoxib treating contracted knees alone, combination with capsular release.A 24 rabbits underwent contracture-forming surgery immobilization followed by remobilization at eight weeks. At...
Abstract Substance P (SP), a neurotransmitter released after injury, has been linked to deregulated tissue repair and fibrosis in musculoskeletal tissues other organs. Although SP inhibition is an effective treatment for nausea, it not previously considered as anti‐fibrotic therapy. there are extensive medical records of individuals who have used antagonists, our analysis human registry data revealed that patients receiving these antagonists arthroplasty exceedingly rare, thus precluding...
The inflammatory cascade and production of prostaglandins may play a role in the pathogenesis arthrofibrosis, debilitating condition after joint replacement other orthopedic procedures. Cyclooxygenase 2 (COX-2) inhibitors mitigate response formation but oral delivery is associated with risk systemic side effects many patients. nonsteroidal anti-inflammatory drug, celecoxib, have therapeutic benefits for current methods its local (e.g., biologically derived microspheres) are not translatable...
Periprosthetic joint infection (PJI) of the knee with concurrent disruption extensor mechanism is a devastating complication. Historically, knees such complications have been salvaged use an arthrodesis or amputation. The purpose this study was to assess survival and functional outcomes 2-stage exchange arthroplasty combined knitted monofilament polypropylene (Marlex; C.R. Bard) mesh reconstruction mechanism.From 2000 2015, 16 patients underwent Marlex-mesh for PJI disruption. included 9...
Arthrofibrosis following total knee arthroplasty (TKA) is a debilitating condition typically diagnosed based on clinical findings. To gain insight into the histopathologic immune cell microenvironment of arthrofibrosis, we assessed extent tissue fibrosis and quantified populations in specific regions posterior capsule. We investigated specimens from three prospectively-collected, matched cohorts, grouped as patients receiving primary TKA for osteoarthritis, revision non-arthrofibrotic,...