A5015114145- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- Mesenchymal stem cell research
- Bone fractures and treatments
- Osteoarthritis Treatment and Mechanisms
- Hip disorders and treatments
- Muscle Physiology and Disorders
- Tissue Engineering and Regenerative Medicine
- Knee injuries and reconstruction techniques
- Formal Methods in Verification
- Shoulder Injury and Treatment
- Logic, Reasoning, and Knowledge
- Logic, programming, and type systems
- Hip and Femur Fractures
- Infectious Diseases and Tuberculosis
- Transcranial Magnetic Stimulation Studies
- Sports injuries and prevention
- Periodontal Regeneration and Treatments
- Nanofabrication and Lithography Techniques
- Spinal Cord Injury Research
- Bayesian Modeling and Causal Inference
- Musculoskeletal Disorders and Rehabilitation
- Inflammatory mediators and NSAID effects
- Tendon Structure and Treatment
Humboldt-Universität zu Berlin
2013-2025
Freie Universität Berlin
2017-2025
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2016-2025
Charité - Universitätsmedizin Berlin
2016-2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2024
Inn-Salzach-Klinikum
2019-2023
RWTH Aachen University
2021-2023
Berlin Heart (Germany)
2023
King's College London
2021
Ludwig-Maximilians-Universität München
2010-2021
We documented the adjunctive bacteriophage therapy to treat a chronic relapsing periprosthetic joint infection of knee and osteomyelitis femur caused by multidrug-resistant Pseudomonas aeruginosa The combined antibiotic-phage treatment eradicated infection, no side effects phages were observed.
In 2013, we introduced a specialized, centralized, and interdisciplinary team in our institution that applied standardized diagnostic treatment algorithm for the management of prosthetic joint infections (PJIs). The hypothesis this study was outcome would be improved using approach.In retrospective analysis with standard postoperative follow-up, 95 patients PJI hip knee who were treated two-stage exchange between 2013 2017 formed group. A historical cohort 86 2009 2011 not according to...
Objective: This study aimed to evaluate the quality and readability of information generated by ChatGPT versions 3.5 4 concerning platelet-rich plasma (PRP) therapy in management knee osteoarthritis (OA), exploring whether large language models (LLMs) could play a significant role patient education. Design: A total 23 common queries regarding PRP OA were presented 4. The responses was assessed using DISCERN criteria, evaluated six established assessment tools. Results: Both produced moderate...
In this paper we present a modular approach for the fabrication of surfaces to characterize protein-protein interactions. The is based on azido peptides with an optimized sequence which are then thiol-functionalized using alkynyl thiol and "click" chemistry. From these peptide thiols fabricated SAMs gold evaluate protein resistance, surface plasmon resonance spectroscopy, toward streptavidin, bovin serum albumin (BSA), fibronectin.
The aim of this study was to determine the prevalence and characteristics C-reactive protein (CRP)-negative prosthetic joint infection (PJI) evaluate influence type infecting organism on CRP level.A retrospective analysis all PJIs affecting hip or knee that were diagnosed in our institution between March 2013 December 2016 performed. A total 215 patients included. Their mean age 71 years (sd 11) there 118 women (55%). median serum levels calculated for various species with acute...
Abstract Background Neurofibromatosis type 1 (NF1) is one of the most common genetic disorders causing learning disabilities by mutations in neurofibromin gene, an important inhibitor RAS pathway. In a mouse model NF1, loss function mutation gene resulted increased gamma aminobutyric acid (GABA)-mediated inhibition which led to decreased synaptic plasticity and deficits attentional performance. Most importantly, these defictis were normalized lovastatin. This placebo-controlled, double...
Abstract Background No regenerative approach has thus far been shown to be effective in skeletal muscle injuries, despite their high frequency and associated functional deficits. We sought address surgical trauma‐related injuries using local intraoperative application of allogeneic placenta‐derived, mesenchymal‐like adherent cells (PLX‐PAD), hip arthroplasty as a standardized injury model, because the immunomodulatory potency this cell type. Methods Our pilot phase I/IIa study was...
Two-stage exchange arthroplasty is still the preferred treatment choice for chronic PJI. However, results remain unpredictable. We analyzed success of patients with an infected hip prosthesis, who were treated according to a standardized algorithm multidisciplinary team approach and evaluated strict definition failure. In this single-center prospective cohort study, all PJI episodes from March 2013 May 2015 included. Treatment failure was assessed Delphi-based consensus definition. The...
Various therapeutic strategies that aim to influence clinical outcome after severe skeletal muscle trauma have been considered. One such method, the local transplantation of stem cells, has shown improve tissue regeneration. The number cells required for successful regeneration, however, remains unclear. this study was therefore examine correlation between transplanted bone marrow-derived mesenchymal (MSCs) and resulting function. week inducing an open crush in 34 female Sprague Dawley rats,...
Clinical findings and blood parameters often are inconclusive in patients with periprosthetic joint infections. Among the accepted criteria for diagnosis, histologic analysis of debrided tissue can detect infection most cases but does not allow intraoperative decision making. We evaluated validity frozen sections detection prosthetic The results from permanent membranes 64 consecutive who underwent exchange procedures after hip arthroplasty were compared using histopathologic consensus...
Fiber type distribution within a skeletal muscle, i.e. the quantification of relative amount 1 (slow‐twitching) and 2 (fast‐twitching) muscle fibers, is great interest for monitoring effects training or treatment diseases. The purpose this study was to determine feasibility diffusion tensor imaging (DTI) as tool noninvasive fiber in human muscle. right calves 12 healthy volunteers were examined using DTI at 1.5 T. Standard parameters, including fractional anisotropy (FA), mean, radial...
Aims The aim of this study was to identify the incidence positive cultures during second stage a two-stage revision arthroplasty and analyse association between an infection-free outcome. Patients Methods This single-centre retrospective review prospectively collected data included patients with periprosthetic joint infection (PJI) either hip or knee 2013 2015, who were treated using standardised diagnostic therapeutic algorithm exchange. Failure treatment assessed according definition...
The COVID-19 pandemic led to the implementation of drastic shutdown measures worldwide. While quarantine, self-isolation and laws helped effectively contain control spread SARS-CoV-2, impact shutdowns on trauma care in emergency departments (EDs) remains elusive.
Platelet-rich plasma (PRP) therapy is increasingly popular to treat musculoskeletal diseases, including tendinopathies and osteoarthritis (OA). To date, it remains unclear which extent PRP compositions are determined by the immune cell cytokine profile of individuals or preparation method. investigate this, we compared leukocyte distributions different products donor blood samples assessed effect pro-inflammatory cytokines on chondrocytes.
Osteoarthritis (OA) is a joint disease featuring cartilage breakdown and chronic pain. Although age trauma are prominently associated with OA occurrence, the trigger signaling pathways propagating their pathogenic aspects ill defined. Following long-term catabolic activity traumatic breakdown, debris accumulates can Toll-like receptors (TLRs). Here we show that TLR2 stimulation suppressed expression of matrix proteins induced an inflammatory phenotype in human chondrocytes. Further, impaired...
Write on target: An efficient and versatile approach to fabricate protein patterns of any shape a variable length scale is developed. The are directly written in an oligo- or poly(ethylene glycol)-based protein-repelling film by electron-beam lithography. Detailed facts importance specialist readers published as "Supporting Information". Such documents peer-reviewed, but not copy-edited typeset. They made available submitted the authors. Please note: publisher responsible for content...