A5016196375- Transcranial Magnetic Stimulation Studies
- Cerebral Palsy and Movement Disorders
- Botulinum Toxin and Related Neurological Disorders
- Neurological disorders and treatments
- Stroke Rehabilitation and Recovery
- EEG and Brain-Computer Interfaces
- Child and Adolescent Psychosocial and Emotional Development
- Muscle activation and electromyography studies
- Infant Development and Preterm Care
- Motor Control and Adaptation
- Functional Brain Connectivity Studies
- Neonatal and fetal brain pathology
- Infant Health and Development
- Vestibular and auditory disorders
- Migration, Health and Trauma
- Childhood Cancer Survivors' Quality of Life
- Child Development and Digital Technology
- Neural dynamics and brain function
- Genetic Neurodegenerative Diseases
- Multiple Sclerosis Research Studies
- Genomics and Rare Diseases
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Neural Engineering
- Child Nutrition and Feeding Issues
- Hereditary Neurological Disorders
Technical University of Munich
2016-2025
German Center for Pediatric and Adolescent Rheumatology
2024-2025
Kliniken des Bezirks Oberbayern
2014-2024
München Klinik
2014-2023
München Klinik Schwabing
2022
Klinikum rechts der Isar
2013-2019
University of Freiburg
1999-2015
University Medical Center Freiburg
2004-2013
Klinik und Poliklinik für Psychotherapie und Psychosomatik
2012
Klinik für Neuropädiatrie und Muskelerkrankungen
2004-2011
Abstract Dystonia is a rare-disease trait for which large-scale genomic investigations are still underrepresented. Genetic heterogeneity among patients with unexplained dystonia warrants interrogation of entire genome sequences, but this has not yet been systematically evaluated. To significantly enhance our understanding the genetic contribution to dystonia, we (re)analyzed 2,874 whole-exome sequencing (WES), 564 whole-genome (WGS), as well 80 fibroblast-derived proteomics datasets,...
To develop and evaluate a clinical Spastic Paraplegia Rating Scale (SPRS) to measure disease severity progression.A 13-item scale was designed rate functional impairment occurring in pure forms of spastic paraplegia (SP). Additional symptoms constituting complicated form SP are recorded an inventory. Two independent patient cohorts were evaluated two-step validation procedure.Application SPRS requires less than 15 minutes does not require any special equipment, so it is suitable for...
This study investigates whether the type of corticospinal reorganization (identified by transcranial magnetic stimulation) influences efficacy constraint‐induced movement therapy (CIMT). Nine patients (five males, four females; mean age 16y [SD 6y 5mo], range 11–30y) controlling their paretic hand via ipsilateral projections from contralesional hemisphere and seven (three 17y 7y], 10–30y) with preserved crossed affected to underwent 12 consecutive days CIMT. A Wolf motor function test...
Sleep is ubiquitous in animals and humans, but its function remains to be further determined. The synaptic homeostasis hypothesis of sleep-wake regulation proposes a homeostatic increase net strength cortical excitability along with decreased inducibility associative long-term potentiation (LTP) due saturation after sleep deprivation. Here we use electrophysiological, behavioural molecular indices non-invasively study LTP-like plasticity humans We demonstrate increased (TMS intensity elicit...
Aim Early unilateral brain lesions can lead to a persistence of ipsilateral corticospinal projections from the contralesional hemisphere, which enable hemisphere exert motor control over paretic hand. In contrast primary representation (M1), somatosensory (S1) hand always remains in lesioned hemisphere. Here, we report on differences exercise‐induced neuroplasticity between individuals with such (ipsi) and early but ‘healthy’ contralateral (contra). Method Sixteen children young adults...
Aim We aimed to investigate the induction of long‐term potentiation (LTP)‐like plasticity by paired associative stimulation (PAS) in patients with high‐functioning autism and Asperger syndrome (HFA/AS). Method PAS an interstimulus interval between electrical transcranial magnetic 25 ms (PAS ) was performed HFA/AS ( n =9; eight males, one female; mean age 17y 11mo, SD 4y 5mo) typically developing age‐matched volunteers five four females; 22y 4mo, 5y 2mo). The amplitude motor‐evoked potentials...
Abstract Background Neurofibromatosis type 1 (NF1) is one of the most common genetic disorders causing learning disabilities by mutations in neurofibromin gene, an important inhibitor RAS pathway. In a mouse model NF1, loss function mutation gene resulted increased gamma aminobutyric acid (GABA)-mediated inhibition which led to decreased synaptic plasticity and deficits attentional performance. Most importantly, these defictis were normalized lovastatin. This placebo-controlled, double...
Psychosocial stress during the COVID-19 pandemic is increasing particularly in parents. Although being specifically vulnerable to negative environmental exposures, research on psychosocial factors infants' and toddlers' families so far sparse. The CoronabaBY study investigates perceived burden, parenting parent child mental health problems with children aged 0-3 years Bavaria, Southern Germany. Further, relationships between these stressors are examined sociodemographic characteristics that...
The use of digital media (e.g., smartphones, tablets, etc.) and the Internet have become omnipresent for every age group are part children's parents' everyday life. Focusing on young children, availability devices, their as well associated problems in social, emotional motor development) increased recent years. Of particular interest prevention these early childhood is relationship between familial context (parental use, Problematic Use, school graduation, presence siblings) infants...
Background Over nearly three years, the COVID-19 pandemic has had a lasting impact on people's lives and mental health worldwide with its far-reaching restrictions concerns about infections other personal consequences. Families were particularly affected showed increased stress psychological problems. Long-term effects cannot be ruled out. So far, data young families are sparse. The present longitudinal analysis ( n = 932) of CoronabaBY study investigated development parenting stress,...
Adductor spasticity in children with cerebral palsy (CP) impairs motor function and development. In a placebo-controlled, double-blind, randomized multicentre study, we evaluated the effects of botulinum toxin A(BTX-A) 61 (37 males, 24 females; mean age 6 years 1 month [SD 3y 1mo]) CP (leg-dominated tetraparesis, n=39; n=22; GMFCS level I, n=3; II, n=6; III, n=17; IV, n=29; V, n=6). Four weeks after treatment, significant superiority BTX-A was observed primary outcome measure (knee-knee...
Objective: The aim of this study was to assess neuromodulative effects CIMT in congenital hemiparesis.
OBJECTIVES. Motor function recovery is a key goal during rehabilitation of children and adolescents with traumatic brain injury. To evaluate how well treatment strategies improve motor function, we need validated outcome measures that are responsive to change in pediatric patients The Gross Function Measure has demonstrated excellent psychometric properties cerebral palsy Down syndrome, yet its responsiveness injury not been proven irrefutably. Our aim was validate the for this patient...
In healthy children, short latency leg muscle reflexes are profoundly modulated throughout the step cycle in a functionally meaningful way and contribute to electromyographic (EMG) pattern observed during gait. With maturation of corticospinal tract, reflex amplitudes depressed via supraspinal inhibitory mechanisms. soleus rhythmic part modulation is present children with cerebral palsy (CP), but development tonic depression increasing age, as seen disturbed. Treadmill training clinically...