A5040926276- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Transcranial Magnetic Stimulation Studies
- Genetic Neurodegenerative Diseases
- EEG and Brain-Computer Interfaces
- Death Anxiety and Social Exclusion
- Vagus Nerve Stimulation Research
- Grief, Bereavement, and Mental Health
- Social and Intergroup Psychology
- Motor Control and Adaptation
- Heart Rate Variability and Autonomic Control
- Muscle activation and electromyography studies
- Neuroscience and Neural Engineering
- Neurological diseases and metabolism
- Vestibular and auditory disorders
- Psychology of Moral and Emotional Judgment
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Ultrasound and Hyperthermia Applications
- Gastroesophageal reflux and treatments
- Hemispheric Asymmetry in Neuroscience
- Action Observation and Synchronization
- Advanced Neuroimaging Techniques and Applications
- Trigeminal Neuralgia and Treatments
Asklepios Fachklinikum Brandenburg
2019-2025
Leipzig University
2015-2025
Asklepios
2021-2024
University Hospital Leipzig
2010-2021
Klinik und Poliklinik für Neurologie
2013-2019
University of Arizona
2009-2017
Texas Christian University
2015
McLaren Regional Medical Center
2000-2015
University of Würzburg
2005-2012
Brigham and Women's Hospital
2011
Study 1 investigated the effect of mortality salience on support for martyrdom attacks among Iranian college students. Participants were randomly assigned to answer questions about either their own death or an aversive topic unrelated and then evaluated materials from fellow students who supported opposed against United States. Whereas control participants preferred student martyrdom, reminded indicated they more likely consider such activities themselves. 2 American students' extreme...
Neuronal plasticity is to be kept within operational limits serve its purpose as a safe memory system that shapes and focuses sensory motor representations. Temporal spatial properties of cortical were assessed in patients with writer's cramp using model long-term potentiation (LTP) depression (LTD) synaptic efficacy. Paired associative stimulation (PAS) combined repetitive electric the median or ulnar nerve (MN UN) subsequent transcranial magnetic contralateral dominant cortex at 21.5 ms...
Two experiments explored age differences in response to reminders of death. Terror management research has shown that death lead increased adherence and defense one's cultural worldview. In Study 1, the effect mortality salience (MS) on evaluations moral transgressions made by younger older adults was compared. Whereas showed typical pattern harsher judgments MS, did not. 2 compared adults' responses both MS induction a more subtle reminder. responded inductions with evaluations,...
Left posterior inferior frontal gyrus (pIFG) and supramarginal (SMG) are key regions for phonological decisions, whereas angular (ANG) anterior IFG (aIFG) associated with semantics. However, it is less clear whether the functional contribution of one area changes in presence a dysfunctional within network. Using repetitive transcranial magnetic stimulation (rTMS), we first tested perturbing would disrupt behavior. Second, applied condition-and-perturb approach, combining parietal offline...
Abstract Dystonia is a rare-disease trait for which large-scale genomic investigations are still underrepresented. Genetic heterogeneity among patients with unexplained dystonia warrants interrogation of entire genome sequences, but this has not yet been systematically evaluated. To significantly enhance our understanding the genetic contribution to dystonia, we (re)analyzed 2,874 whole-exome sequencing (WES), 564 whole-genome (WGS), as well 80 fibroblast-derived proteomics datasets,...
Research on terror management theory (TMT) indicates that reminders of death affect political attitudes, but orientation only sometimes moderates these effects. We propose secure relationships are associated with values tolerance and compassion, thus orienting people toward liberalism; insecure attachments more rigid absolutist orient conservatism. Given attachment become especially active when security needs heightened, we predicted mortality salience would be an important factor in...
The ability of synapses to undergo persistent activity-dependent potentiation or depression [long-term (LTP)/long-term (LTD)] may be profoundly altered by previous neuronal activity. Although natural activity can experimentally manipulated in vivo , very little is known about the physiological mechanisms involved regulating this metaplasticity models LTP/LTD. To examine whether Ca 2+ signaling influence humans, we used continuous theta burst stimulation (cTBS) (Huang et al., 2005), a...
Vagus nerve stimulation (VNS) has become a well-established therapy for epilepsy and depression, is emerging to treat inflammatory disease, with the cervical vagus (CVN) as major site. CVN morphometries are missing VNS, considering its variability. Morphometric data were obtained from CVNs in 27 cadavers, including branching patterns histology. Cross-sectional area, greater lesser diameters averaged 7.2 ± 3.1 mm2, 5.1 1.5 4.1 1.3 mm, ≤11.0 ≤7.0 ≤5.8 mm 90% of specimens, respectively. Midline...
The subthalamic nucleus (STN) plays a crucial role in the surgical treatment of Parkinson's disease (PD). Studies investigating optimal protocols for STN visualization using state art magnetic resonance imaging (MRI) techniques have shown that susceptibility weighted images, which display distribution, yield better results than T1-weighted, T2-weighted, and T2*-weighted contrasts. However, these findings are based on young healthy individuals, require validation elderly individuals persons...
Reported sonographic reference values for the vagus nerves (VNs) vary greatly. We aimed to generate in a large cohort and examine intrarater, interrater, across-ultrasound systems agreement.The VNs of 60 healthy subjects were examined by 2 sonographers with ultrasound systems. Cross-sectional areas (CSAs) each VN assessed at level carotid sinus [proximal measurement (ML)] thyroid gland (distal ML).Mean CSA was significantly larger on right side (proximal ML: 2.7 ± 0.6 mm2 vs. 2.1 0.5 ;...
Abstract From an existential terror management theory perspective, disgusting stimuli are threatening to human beings because they make salient people's vulnerability death. Two studies were designed assess this proposition by measuring implicit death‐related ideation after individuals presented with that either or not disgusting, under conditions in which the similarities of humans other animals uniquely aspects people made salient. In Study 1, rather extreme disgust‐eliciting pictures...
Patients with dystonia display a number of disturbances in the cognitive processing movements, such as movement simulation and prediction, but whether these deficits point to deeper rooted disturbance perceptual bodily representations remains unknown. A useful way investigate sense body ownership is rubber hand paradigm, which an illusion established by synchronous stroking participants' real unseen visible fake hand, whereas similar asynchronous does not bring about illusion. This paradigm...
Previous terror management theory research has shown that mortality salience (MS; a death reminder) leads to the derogation of those who are perceived be threats or violators one’s cultural worldview. Immigrants may viewed as such threat, but not necessarily all majority group members culture. The studies presented here tested hypothesis that, depending upon nature participants’ worldview, MS would either increase decrease liking an immigrant. After being reminded their control topic, French...
Background: Recent histopathological studies revealed degeneration of the dorsal motor nucleus early in course Parkinson's disease (PD). Degeneration vagus nerve (VN) axons following neurodegeneration brainstem vagal nuclei should be detectable by high-resolution ultrasound (HRUS) as a thinning VNs. Methods: We measured both VNs cross-sectional area (VN-CSA) 35 patients with PD and age- sex-matched healthy controls at level thyroid gland using HRUS. Results: On sides, VN-CSA was...
<h3>Background:</h3> Structural abnormality of the substantia nigra can be detected by transcranial sonography in neuropsychiatric disorders such as Parkinson disease and restless legs syndrome. We investigated echogenicity a potential structural marker for dysfunction nigrostriatal dopamine system children with attention-deficit hyperactivity disorder (ADHD). <h3>Methods:</h3> used blinded design determined use 22 ADHD healthy controls matched age sex. <h3>Results:</h3> The echogenic area...
Abstract Transcranial sonography (TCS) reveals abnormal spatial extension of substantia nigra (SN) echogenicity in a high proportion patients with Parkinson's disease (PD). It has been proposed that this abnormality represents structural trait is mechanistically distinct from degeneration dopaminergic nigrostriatal projection neurons. We sought to clarify the relationship between sonographic abnormalities SN and dysfunction striatal neurotransmission. studied 50 PD. The echogenic area was...