A5058628644- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Neuroscience and Music Perception
- Genetic Neurodegenerative Diseases
- Motor Control and Adaptation
- Transcranial Magnetic Stimulation Studies
- Advanced Neuroimaging Techniques and Applications
- Voice and Speech Disorders
- Parkinson's Disease Mechanisms and Treatments
- Hereditary Neurological Disorders
- Functional Brain Connectivity Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Advanced MRI Techniques and Applications
- Genomics and Rare Diseases
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Neurogenetic and Muscular Disorders Research
- Ophthalmology and Eye Disorders
Klinikum rechts der Isar
2015-2025
Technical University of Munich
2015-2025
Klinik und Poliklinik für Neurologie
2016-2020
Blepharospasm is characterized by involuntary eyelid spasms. It can be associated with perioral dystonia (Meige's syndrome or orofacial dystonia). We aimed at studying resting-state functional brain connectivity in these patients and its potential modulation therapeutic botulinum toxin injections. performed MRI a region of interest-based analysis 13 blepharospasm/Meige's comparison to healthy controls. Patients were studied before 4 weeks after treatment. Simultaneous facial electromyography...
ABSTRACT Objective : Embouchure dystonia is a highly disabling task‐specific in professional brass musicians leading to spasms of perioral muscles while playing the instrument. As they are asymptomatic at rest, resting‐state functional magnetic resonance imaging these patients can reveal changes connectivity within and between brain networks independent from dystonic symptoms. Methods We therefore compared embouchure healthy with combination component analyses. Results Patients showed...
ABSTRACT Background While automated methods for differential diagnosis of parkinsonian syndromes based on MRI imaging have been introduced, their implementation in clinical practice still underlies considerable challenges. Objective To assess whether the performance classifiers derived biomarkers is improved with addition basic information and to provide a practical solution address insecurity classification results due uncertain they are on. Methods Retro‐ prospectively collected data from...
Writer's cramp is a task-specific dystonia impairing writing and sometimes other fine motor tasks. Neuroimaging studies using manifold designs have shown varying results regarding the nature of changes in disease. To clarify extend knowledge underlying by investigating functional connectivity (FC) intrinsic networks with putative sensorimotor function at rest an increased number study subjects. Resting-state magnetic resonance imaging independent component analysis was performed 26/27...
ABSTRACT Background Embouchure dystonia is a highly disabling focal task‐specific affecting professional brass players. Objective This study was designed to analyze activity changes along with topographic representations in primary and nonprimary centers for somatosensory processing patients embouchure dystonia. Methods We used event‐related functional magnetic resonance imaging automized tactile stimulation of dystonic (upper lip) nondystonic (forehead dorsal hand) body regions 15 players...
Abstract Adductor-type spasmodic dysphonia (ADSD) manifests in effortful speech temporarily relievable by botulinum neurotoxin type A (BoNT-A). Previously, abnormal structure, phonation-related and resting-state sensorimotor abnormalities as well peripheral tactile thresholds ADSD were described. This study aimed at assessing central processing patterns, their spatial relation with dysfunctional connectivity, BoNT-A responsiveness. Functional MRI 14/12 patients before/under effect 15...
Blepharospasm is a debilitating focal dystonia characterized by involuntary eyelid spasms that can be accompanied oromandibular muscle involvement (Meige's syndrome). Frequently observed abnormality in functional neuroimaging hints at an important position of the thalamus, relays involved cortico-basal ganglia-cortical and cortico-cerebello-cortical circuits, within abnormal network blepharospasm. To characterize cortico-thalamic structural/streamline connectivity (SC) patterns disease, as...
Embouchure dystonia (ED) is a task-specific focal in professional brass players leading to abnormal orofacial muscle posturing/spasms during performance. Previous studies have outlined cortical sensorimotor function sensory/motor tasks and the resting state as well structure. Yet, potentially underlying white-matter tract abnormalities this network disease are unknown. To delineate structure-function within cerebral trajectories ED. Probabilistic tractography seed-based functional...
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Embouchure dystonia (ED) is a task-specific movement disorder that leads to loss of fine motor control the embouchure and tongue muscles in wind musicians. In contrast musicians' hand dystonia, no validated severity rating for ED exists, posing major obstacle structured assessment scientific clinical settings. The aim this study validate an scale (EDSRS) allowing standardized estimation symptom ED.The EDSRS was set up as composite score six items evaluating audio-visual disease symptoms...