A5076231030- Neurological disorders and treatments
- Motor Control and Adaptation
- Botulinum Toxin and Related Neurological Disorders
- Muscle activation and electromyography studies
- Genetic Neurodegenerative Diseases
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Neuroscience and Music Perception
- Advanced Neuroimaging Techniques and Applications
- Tactile and Sensory Interactions
- Neurogenetic and Muscular Disorders Research
- Sports Performance and Training
- Parkinson's Disease Mechanisms and Treatments
- Parkinson's Disease and Spinal Disorders
- Peripheral Neuropathies and Disorders
- Action Observation and Synchronization
- Stroke Rehabilitation and Recovery
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Genomics and Rare Diseases
- Ion channel regulation and function
- Research on Leishmaniasis Studies
- Cerebral Palsy and Movement Disorders
- Multiple Myeloma Research and Treatments
Technical University of Munich
2016-2024
Klinikum rechts der Isar
2017-2024
Klinik und Poliklinik für Neurologie
2016-2020
The University of Melbourne
2018
Université Paris Cité
2018
Erasmus MC
2018
Maastricht University
2018
University Medical Center
2018
University Hospital and Clinics
2018
Academic Medical Center
2018
ABSTRACT Background Dystonia is clinically and genetically heterogeneous. Despite being a first‐line testing tool for heterogeneous inherited disorders, whole‐exome sequencing has not yet been evaluated in dystonia diagnostics. We set up pilot study to address the yield of early‐onset generalized dystonia, disease subtype enriched monogenic causation. Methods Clinical coupled with bioinformatics analysis detailed phenotyping mutation carriers was performed on 16 consecutive cases undefined...
Writer's cramp is a task-specific dystonia impairing writing and sometimes other fine motor tasks. Neuroimaging studies using manifold designs have shown varying results regarding the nature of changes in disease. To clarify extend knowledge underlying by investigating functional connectivity (FC) intrinsic networks with putative sensorimotor function at rest an increased number study subjects. Resting-state magnetic resonance imaging independent component analysis was performed 26/27...
Abstract Adductor-type spasmodic dysphonia (ADSD) manifests in effortful speech temporarily relievable by botulinum neurotoxin type A (BoNT-A). Previously, abnormal structure, phonation-related and resting-state sensorimotor abnormalities as well peripheral tactile thresholds ADSD were described. This study aimed at assessing central processing patterns, their spatial relation with dysfunctional connectivity, BoNT-A responsiveness. Functional MRI 14/12 patients before/under effect 15...
Blepharospasm is a debilitating focal dystonia characterized by involuntary eyelid spasms that can be accompanied oromandibular muscle involvement (Meige's syndrome). Frequently observed abnormality in functional neuroimaging hints at an important position of the thalamus, relays involved cortico-basal ganglia-cortical and cortico-cerebello-cortical circuits, within abnormal network blepharospasm. To characterize cortico-thalamic structural/streamline connectivity (SC) patterns disease, as...
This study describes a technique for measuring human grip forces exerted on cylindrical object via sensor array. Standardised resistor-based pressure arrays industrial and medical applications have been available some time. We used special 20 mm diameter rod that subjects could either move actively with their fingers in the horizontal direction or exert reactive against opposing generated by linear motor. The array film was attached to adhesive tape covered approximately 45 cm(2) of surface....
Embouchure dystonia (ED) is a task-specific focal in professional brass players leading to abnormal orofacial muscle posturing/spasms during performance. Previous studies have outlined cortical sensorimotor function sensory/motor tasks and the resting state as well structure. Yet, potentially underlying white-matter tract abnormalities this network disease are unknown. To delineate structure-function within cerebral trajectories ED. Probabilistic tractography seed-based functional...
The "raspberry task" represents a precision grip task that requires continuous adjustment of forces and pull forces. During this task, subjects use specialised rod have to increase the force linearly while is locked. positions fingers are unrestrained freely selectable. From finger geometry rod, physical lever was derived which comprehensive measurement subject's behaviour. In study, involvement cerebellum in establishing cued changes (CFC) examined. auditory stimulus associated with motor...
The central nervous system adapts the gain of short-latency reflex loops to changing conditions. Experiments on biomimetic robots showed that modulation could substantially increase energy efficiency and stability periodic motions if, unlike known mechanisms, both acted precisely muscles involved lasted after motion. This study tests presence such a mechanism by having participants repeatedly rotate either their right elbow or shoulder joint, before perturbing joint. results demonstrate...
<title>Abstract</title> Neuromodulation plays a central role in human movement control. An imbalance of neurotransmitters, especially dopamine and serotonin, can be associated with various neurological disorders causing tremors or spasms. Specifically, serotonin was shown to scale motoneuron excitability following intense muscle contractions, affecting short-latency reflexes. Likely, it may also influence modulation prolonged although this lacks experimental evidence. intriguing test case...
Zusammenfassung Wir schildern den Fall einer 74-jährigen Patientin, die ab dem 60. Lebensjahr ein progressives Krankheitsbild mit sensibler Neuropathie, zerebellärer Ataxie und bilateraler Vestibulopathie entwickelte. Die Familienanamnese war leer. Magnetresonanztomographisch zeigten sich eine im Vermis betonte Kleinhirnatrophie sowie Myelonatrophie. Syndromal wurde CANVAS (zerebelläre Ataxie, vestibuläre Areflexie Syndrom) diagnostiziert. Für diese Erkrankung 2019 der Gendefekt beschrieben,...