A5081018630- Venous Thromboembolism Diagnosis and Management
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Lymphoma Diagnosis and Treatment
- Platelet Disorders and Treatments
- Viral-associated cancers and disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cardiac tumors and thrombi
- Air Quality and Health Impacts
- Childhood Cancer Survivors' Quality of Life
- Multiple Myeloma Research and Treatments
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Neutropenia and Cancer Infections
- Atrial Fibrillation Management and Outcomes
- Cerebral Venous Sinus Thrombosis
- Hemophilia Treatment and Research
- Climate Change and Health Impacts
- Blood donation and transfusion practices
- Inflammatory Biomarkers in Disease Prognosis
- Child Nutrition and Water Access
- Gout, Hyperuricemia, Uric Acid
- Blood groups and transfusion
- Galectins and Cancer Biology
Chiang Mai University
2022-2025
Background Cerebral venous sinus thrombosis (CVST) is a rare type of that affects the cerebral system. The data on neurological outcomes are limited. Objectives This study aimed to investigate CVST, contributing factors, clinical presentation, treatment and mortality. Methods was single-center, retrospective at university-based referral hospital in Thailand. Consecutive patients diagnosed with CVST between January 2010 December 2020 were included. Outcomes measured by modified Rankin Scale...
Background/Objectives: The incidences of venous thromboembolism (VTE) in patients undergoing neurological surgeries vary. objectives were to assess the incidence and risk factors VTE, bleeding all-cause mortality surgery. Methods: This retrospective cohort study was conducted at a single center, university-based hospital Thailand. Inclusion criteria comprised aged 15 years or older who admitted for elective emergency neurosurgery. Patients with preoperative VTE diagnosed within three months...
Aim: Exposure to fine particulate matter, particularly PM2.5, has been associated with increased platelet activation and cardiovascular risks. However, its effect on recovery after transfusion remains unclear. Purpose: This study aims assess the influence of PM2.5 exposure in patients hematologic malignancies receiving prophylactic transfusions. Patients Methods: We conducted a cross-sectional involving 66 who developed chemotherapy-induced thrombocytopenia received transfusions between...
ABSTRACT Introduction Data regarding long‐term clinical outcomes in Asian patients with acquired haemophilia A (AHA) was limited. Aim This study aimed to evaluate the effectiveness of current treatments and their a real‐world setting among Thai AHA. Methods retrospective cohort conducted at university‐based hospital. Patients’ characteristics, treatment patterns disease were collected. Univariate multivariate Gray's competing risk analyses used examine factors related time response. Results...
Anticoagulant prescription and management are crucial steps of venous thromboembolism (VTE). The Clinical decision support systems (CDSS) designed developed to aid healthcare professionals in making informed decisions. To develop assess the efficacy mobile app-based CDSS for VTE. A randomized controlled trial was conducted, enrolling participants aged ≥ 20 years who were one following categories: medical student, intern, internal medicine resident, or hematology fellow. Participants randomly...
Introduction: Pediatric acute lymphoblastic leukemia (ALL) has cure rates exceeding 90%, while adult ALL a 3-year survival rate of only 40–50%. Adolescents and young adults (AYAs) face unique challenges due to age-related factors high-risk disease features. Although pediatric-inspired regimens improve survival, intensive chemotherapy increases susceptibility severe infections. Methods: A retrospective analysis was conducted on AYA-ALL patients treated at Chiang Mai University Hospital from 1...
Background A common complication of thalassemia is secondary osteoporosis. This study aimed to assess the prevalence and factors associated with low BMD in thalassemic patients. Method a cross-sectional study. Eligible patients were males aged within 18–49 years or premenopausal women diagnosed Chiang Mai University Hospital between July 2021 2022. The diagnosis by dual-energy x-ray absorptiometry (DXA) was defined as Z-score -2.0 SD lower either lumbar spine femoral neck. Clinical analyzed...
Introduction Elevated ambient pollution exposure is potentially linked to thromboembolism. However, the mechanisms by which particulate matter (PM) interferes with balance of hemostatic system remain unclear. This study investigates PM-mediated changes in individuals across unique seasonal variations pollution. Methods prospective was conducted between February and July 2020 during alterations Chiang Mai, Thailand. Blood tests from 30 healthy subjects were assessed at four-week intervals,...
Hyperuricemia is a common complication of hematologic malignancies, and hyperuricosuria in this population has shown conflicting results. This study aimed to determine the prevalence hyperuricemia parameters associated with serum uric acid (SUA) urine (UUA) patients lymphoma myeloproliferative neoplasms (MPN).
Despite the conflicting data, positivity of antiphospholipid antibodies (aPL) in cancer patients may be associated with an increased risk thrombosis.To identify prevalence and impact aPL on venous thromboembolic events (VTE) arterial thrombosis (ATE) ambulatory patients.In this single-center, prospective cohort study, we enrolled newly diagnosed receiving chemotherapy. Non-cancer controls were age- sex-matched. Participants evaluated for aPL. Primary outcomes composite outcome VTE or ATE...
A splenectomy can reduce transfusion requirements in patients with thalassemia. However, the role of a remains controversial because its efficacy has not yet been fully determined and there are concerns over potential complications. The purpose this study was to assess efficacy, changes hematologic parameters, any complications associated splenectomy.Medical records 50 transfusion-dependent thalassemia (TDT) who had undergone splenectomy, along those 20 control subjects intact spleens, were...
Anti-platelet factor 4 (anti-PF4) antibodies were identified as pathogenic for vaccine-induced immune thrombocytopenia and thrombosis (VITT) in subjects receiving ChAdOx1 nCoV-19 vaccinations. We performed a prospective cohort study to determine the prevalence of anti-PF4 effect vaccine on healthy Thai subjects. Anti-PF4 measured before four weeks after first vaccination. Participants with detectable scheduled repeat analysis at 12 second Of 396 participants, ten participants (2.53%; 95%...
There are limited data regarding the impact of disease-related complications on survival multiple myeloma (MM) patients. The primary objective this study was to determine prevalence complications, including hypercalcemia, renal insufficiency, anemia, and bone lytic lesions in MM secondary objectives were clinical characteristics, treatment outcomes, association mortality. A retrospective chart review patients from November 2014 December 2019 conducted. total 200 enrolled. median age at...
Background:Autologous stem cell transplantation (ASCT) is the standard treatment for multiple myeloma (MM) and refractory/relapsed (R/R) lymphoma patients.Engraftment syndrome (ES) a non-infectious febrile during ASCT.This study focused on incidence, risk factors, manifestations, outcomes of patients with ES receiving ASCT. Material/Methods:This retrospective cohort included MM R/R who underwent ASCT at Chiang Mai University Hospital from January 2014 to September 2020.ES was diagnosed by...
: Rivaroxaban and dabigatran are commonly used for thromboembolic disease management in active cancer patients. However, limited research explores the impact of concurrent chemotherapy on pharmacodynamics direct oral anticoagulants (DOAC). The aim our study was to evaluate combined with rivaroxaban patients diffuse large B-cell lymphoma (DLBCL).;
Background/Objectives: The primary objective of this study was to investigate clinical manifestations, time diagnosis, and number biopsies in patients with extranodal natural killer T-cell lymphoma (ENKTL). secondary objectives were determine response rates, survival outcomes, prognostic factor for overall (OS), validation the Prognostic Index Natural Killer Lymphoma (PINK), Ann Arbor staging system (AASS), CA system. Methods: This retrospective included data pertaining newly diagnosed ENKTL...
Objective: Tyrosine kinase inhibitor (TKI) is the standard treatment for chronic myeloid leukemia (CML). In national list of essential medicines in Thailand, first, second, and third-line treatments are imatinib, nilotinib, dasatinib, sequentially, different from European Leukemia Net guidelines. This study aimed to evaluate outcomes CML patients who received sequential with TKI. Methods: enrolled diagnosed between 2008 2020 at Chiang Mai University Hospital Medical records were reviewed...
Deferiprone (DFP) is an oral iron-chelating agent that widely used in thalassemia patients with iron overload. This study aimed to investigate the long-term efficacy of DFP monotherapy on serum ferritin (SF) and adverse events. All aged 15 years or older who received were identified from registry database between November 2008 October 2019. After treatment, achieved a target SF level, defined as <1000.0 ng/mL transfusion-dependent (TDT) <800.0 non-TDT (NTDT) for two consecutive visits,...
This study aimed to evaluate the performance of D-index, a calculated measure neutropenic burden, in predicting risk invasive fungal infections (IFIs) acute myeloid leukemia (AML) patients.A retrospective adult AML patients who received first induction chemotherapy and developed febrile neutropenia was conducted. Clinical characteristics, laboratory data, calculation D-index cumulative (c-D-index) were collected analyzed between with without IFIs.A total 101 included, 16 (15.8%) IFIs....
Objectives To compare the efficacy and side effects of salvage chemotherapy between etoposide, methylprednisolone, cytarabine cisplatin (ESHAP) ifosfamide, carboplatin etoposide plus dexamethasone (DICE) for relapsed or refractory diffuse large B-cell lymphoma (DLBCL).