A5081430078- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Neural and Behavioral Psychology Studies
- Neuroendocrine regulation and behavior
- Neural dynamics and brain function
- Neuroinflammation and Neurodegeneration Mechanisms
- Autism Spectrum Disorder Research
- Circadian rhythm and melatonin
- Stress Responses and Cortisol
- Genetics and Neurodevelopmental Disorders
- Obsessive-Compulsive Spectrum Disorders
- Intelligent Tutoring Systems and Adaptive Learning
- Sleep and Wakefulness Research
- Global Political and Economic Relations
- Foreign Language Teaching Methods
- Legal and Policy Issues
UNSW Sydney
2019-2024
American Dental Education Association
2023
John Wiley & Sons (United States)
2023
The University of Sydney
2011-2015
University of Saint Joseph
2009-2012
Considerable evidence suggests that choice between goal‐directed actions depends on two incentive processes encoding the reward value of goal or outcome and predicted an action based outcome‐related stimuli. Although theories generally assume these are mediated by a common associative mechanism, number recent findings suggest they dissociable; is derived from consummatory experience with itself, whereas presence outcome‐associated stimuli which estimates likelihood derived. Importantly,...
Two motivational processes affect choice between actions: (1) changes in the reward value of goal or outcome an action and (2) predicted based on outcome-related stimuli. Here, we evaluated role μ-opioid receptor (MOR) δ-opioid (DOR) nucleus accumbens way these influence using revaluation pavlovian-instrumental transfer tests. We first examined effect genetic deletion MOR DOR specific knock-out mice. then assessed infusing antagonist d -Phe-Cys-Tyr- -Trp-Arg-Thr-Pen-Thr-NH 2 (CTAP)...
Outcome-specific Pavlovian-instrumental transfer (PIT) demonstrates the way that reward-related cues influence choice between instrumental actions. The nucleus accumbens shell (NAc-S) contributes critically to this effect, particularly through its output rostral medial ventral pallidum (VP-m). Using rats, we investigated in two experiments role PIT effect of major outputs VP-m region innervated by NAc-S, mediodorsal thalamus (MD) and tegmental area (VTA). First, retrograde tracers were...
Abstract The basolateral amygdala (BLA) complex receives dense cholinergic projections from the nucleus basalis of Meynert (NBM) and horizontal limb diagonal band Broca (HDB). present experiments examined whether these regulate formation, extinction, renewal fear memories. This was achieved by employing a Pavlovian conditioning protocol optogenetics in transgenic rats. Silencing NBM during weakened memory produced that abolished its after extinction. By contrast, silencing HDB had no effect....
The posterior dorsomedial striatum (pDMS) is essential for the acquisition and expression of specific response-outcome (R-O) associations that underlie goal-directed action. Here we examined role a pathway linking basolateral amygdala (BLA) pDMS in such learning. In Experiment 1, rats received unilateral lesions BLA were implanted with cannula targeting either ipsilateral (control) or contralateral (disconnection) hemisphere. After initial training, infusions muscimol to inactivate...
The nucleus accumbens shell (NAc-S) plays an important role in the way stimuli that predict reward affect performance of, and choice between, goal-directed actions tests of outcome-specific Pavlovian-instrumental transfer (PIT). neural processes involved PIT downstream ventral striatum are, however, unknown. NAc-S projects prominently to pallidum (VP), current experiments, we assessed involvement VP projection specific rats. We first compared expression immediate-early gene c-Fos medial...
Cortico-striatal neurocircuits mediate goal-directed and habitual actions which are necessary for adaptive behaviour. It has recently been proposed that some of the core symptoms autism spectrum disorder (ASD) Gilles de la Tourette syndrome (GTS), such as tics other repetitive behaviours, may emerge because imbalances in these neurocircuits. We have developed a model ASD GTS by knocking down Immp2l, mitochondrial gene frequently associated with disorders. The current study sought to...
The loss of neurons in parafascicular thalamus (Pf) and their inputs to dorsomedial striatum (DMS) Lewy body disease (LBD) Parkinson’s dementia (PDD) have been linked the effects neuroinflammation. We found that, rats, these were necessary for both function striatal cholinergic interneurons (CINs) flexible encoding action-outcome (AO) associations goal-directed action, producing a burst-pause pattern CIN firing but only during remapping elicited by shift AO contingency. Neuroinflammation Pf...
Obesity can disrupt how food-predictive stimuli control action performance and selection. These two forms of recruit cholinergic interneurons (CIN) located in the nucleus accumbens core (NAcC) shell (NAcS), respectively. Given that obesity is associated with insulin resistance this region, we examined whether interfering CIN signaling disrupts actions. To interfere used a high-fat diet (HFD) or genetic excision receptor (InsR) from cells. HFD left intact capacity to energize an earning food...
Abstract Obesity can disrupt how food-predictive stimuli control action performance and selection. These two forms of recruit cholinergic interneurons (CIN) located in the nucleus accumbens core (NAcC) shell (NAcS), respectively. Given that obesity is associated with insulin resistance this region, we examined whether interfering CIN signaling disrupts actions. To interfere used a high-fat diet (HFD) or genetic excision receptor (InsR) from cells. HFD left intact capacity to energize an...
ABSTRACT The loss of neurons in parafascicular thalamus (Pf) and their inputs to dorsomedial striatum (DMS) are associated with Lewy body disease (LBD) Parkinson’s dementia (PDD) have been linked the effects neuroinflammation. In rats, these regulate function striatal cholinergic interneurons (CINs) that necessary for flexible encoding action-outcome (AO) associations goal-directed action. We found modify encoding, not retrieval, new AO cause burst-pause firing CINs DMS during remapping....
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Abstract Cortico-striatal neurocircuits mediate goal-directed and habitual actions which are necessary for adaptive behaviour. It has recently been proposed that some of the core symptoms autism spectrum disorder (ASD) Gilles de la Tourette syndrome (GTS), such as tics repetitive behaviours, may emerge because imbalances in these neurocircuits. We have developed a model ASD GTS by knocking down Immp2l , mitochondrial gene frequently associated with disorders. The current study sought to...
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An abstract is not available for this content so a preview has been provided. As you have access to content, full PDF via the ‘Save PDF’ action button.
An abstract is not available for this content so a preview has been provided. As you have access to content, full PDF via the ‘Save PDF’ action button.
An abstract is not available for this content so a preview has been provided. As you have access to content, full PDF via the ‘Save PDF’ action button.
An abstract is not available for this content so a preview has been provided. As you have access to content, full PDF via the ‘Save PDF’ action button.