A5066599605- Genetics, Aging, and Longevity in Model Organisms
- Chromosomal and Genetic Variations
- Neurobiology and Insect Physiology Research
- Genetic diversity and population structure
- Genetic Mapping and Diversity in Plants and Animals
- Mitochondrial Function and Pathology
- Evolution and Genetic Dynamics
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Plant Virus Research Studies
- Insect symbiosis and bacterial influences
- Physiological and biochemical adaptations
- Genomics and Phylogenetic Studies
- Genetics and Neurodevelopmental Disorders
- CRISPR and Genetic Engineering
- Adipose Tissue and Metabolism
- Insect and Arachnid Ecology and Behavior
- Genomics and Chromatin Dynamics
- Viral Infectious Diseases and Gene Expression in Insects
- Developmental Biology and Gene Regulation
- Sirtuins and Resveratrol in Medicine
- Coenzyme Q10 studies and effects
- Tryptophan and brain disorders
- Animal Genetics and Reproduction
- Genetic and phenotypic traits in livestock
Kurchatov Institute
2008-2025
Institute of Molecular Genetics
2015-2024
Czech Academy of Sciences, Institute of Molecular Genetics
2023
Moscow State Pedagogical University
2022
Russian Academy of Sciences
2005-2019
North Carolina State University
1997-2004
University of California, Davis
2004
Université Claude Bernard Lyon 1
1985
Abstract The nature of genetic variation for Drosophila longevity in a population recombinant inbred lines was investigated by estimating quantitative parameters and mapping trait loci (QTL) adult life span five environments: standard culture conditions, high low temperature, heat-shock starvation stress. There highly significant within each sex environment. In the analysis variance pooled over sexes environments, however, appeared genotype × environment interaction terms. correlation across...
Senescence, the decline in survivorship and fertility with increasing age, is a near-universal property of organisms. Senescence limited lifespan are thought to arise because weak natural selection late life allows accumulation mutations deleterious late-age effects that either neutral (the mutation hypothesis) or beneficial antagonistic pleiotropy early life. Analyses Drosophila spontaneous mutations, patterns segregating variation covariation, lines selected for have implicated both...
Genetic variation is the fuel of evolution, with standing genetic especially important for short-term evolution and local adaptation. To date, studies spatiotemporal patterns in natural populations have been challenging, as comprehensive sampling logistically difficult, sequencing entire costly. Here, we address these issues using a collaborative approach, 48 pooled population samples from 32 locations, perform first continent-wide genomic analysis European Drosophila melanogaster. Our...
Abstract Drosophila melanogaster is a leading model in population genetics and genomics, growing number of whole-genome data sets from natural populations this species have been published over the last years. A major challenge integration disparate sets, often generated using different sequencing technologies bioinformatic pipelines, which hampers our ability to address questions about evolution species. Here we these issues by developing bioinformatics pipeline that maps pooled (Pool-Seq)...
Abstract In a previous study, sex-specific quantitative trait loci (QTL) affecting adult longevity were mapped by linkage to polymorphic roo transposable element markers, in population of recombinant inbred lines derived from the Oregon and 2b strains Drosophila melanogaster. Two life span QTL each located on chromosomes 2 3, within sections 33E–46C 65D–85F cytological map, respectively. We used deficiency complementation mapping further resolve locations these regions. The crossed 47...
Understanding the genetic and environmental factors that affect variation in life span senescence is of major interest for human health evolutionary biology. Multiple mechanisms longevity, many which are conserved across species, but networks underlying each mechanism cross-talk between unknown. We report results a screen mutations affecting Drosophila span. One third 1,332 homozygous P-element insertion lines assessed had quantitative effects on span; reducing were twice as common...
Replicates of the two isogenic laboratory strains Drosophila melanogaster, 2b and Harwich, contain different average transposable element (TE) copy numbers in same genetic background. These lines were used to analyze correlation between TE number fitness. Assuming a weak deleterious effect each insertion, decrease fitness is expected with an increase genomic number. Higher rates ectopic exchanges and, consequently, chromosomal rearrangements resulting early embryonic death are also predicted...
Abstract The magnitude of segregating variation for bristle number in Drosophila melanogaster exceeds that predicted from models mutation-selection balance. To evaluate the hypothesis genotype-environment interaction (GEI) maintains nature, we quantified extent GEI abdominal and sternopleural bristles among 98 recombinant inbred lines, derived two homozygous laboratory strains, three temperature environments. There was considerable both traits, which mainly attributable to changes rank order...
OPINION article Front. Genet., 31 October 2012Sec. Genetics of Aging Volume 3 - 2012 | https://doi.org/10.3389/fgene.2012.00224
Summary The insertion site polymorphism of the copia, mdg1, mdg3, gypsy, and P transposable elements was analysed by in situ hybridization to polytene chromosomes genomes males from a natural population Drosophila melanogaster . Parameters various theoretical models biology were estimated our data, different hypotheses explaining TE copy number containment tested. mdg1 gypsy show evidence for deficiency insertions on X chromosomes, result consistent with selection against mutational effects...
A fundamental assumption of models for the maintenance genetic variation by environmental heterogeneity is that selection favours alternative alleles in different environments. It not clear, however, whether such antagonistic pleiotropy common. We mapped quantitative trait loci (QTLs) causing reproductive performance each three treatments among a set 98 recombinant inbred (RI) lines derived from cross between two D. melanogaster laboratory strains. The were standard medium at 25°C,...
We examined the genetic architecture of four fitness-related traits (reproductive success, ovariole number, body size and early fecundity) in a panel 98 Oregon-R × 2b3 recombinant inbred lines (RILs). Highly significant variation was observed this population for female, but not male, reproductive success. The cross-sex correlation success 0·20, which is significantly different from zero. There segregating cross or fecundity. RILs were genotyped cytological insertion sites roo transposable...
In an inbred low-activity (LA) strain of Drosophila melanogaster with a low level fitness and complex inadaptive characters, in situ hybridization reveals invariant pattern distribution three copia-like elements (mdg-1, mdg-3, copia). Rare, spontaneous, multiple transpositions mobile the LA were shown to be coupled drastic increase fitness. A changed various types was also observed on selecting for higher High-fitness strains show definite chromosomal sites ("hot spots"). Concerted changes...
An animal's survival strongly depends on its ability to maintain homeostasis in response the changing quality of external and internal environment. This is achieved through intracellular intercellular communication within among different tissues. One organ systems that plays a major role this maintenance nervous system. Here we highlight aspects neuronal inputs outputs pathways affect aging longevity. Accordingly, discuss how sensory influence lifespan modulation types signals, which...
Rates of copia transposition were determined directly, by cytological in situ hybridization analysis sites insertion progeny males from sublines an inbred strain with different genomic copy numbers. Copia rate was positively and nonlinearly associated number. This relation cannot be simply explained mutations a single host factor that normally supresses transposition, or elements themselves. We postulate the number virus- like particles, necessary for could depend on Deleterious side-effects...
Summary Variation in longevity natural populations is attributable to the segregation of multiple interacting loci, whose effects are sensitive environment. Although there has been considerable recent progress towards understanding environmental factors and genetic pathways that regulate lifespan, little known about genes causing naturally occurring variation longevity. Previously, we used deficiency complementation mapping map two closely linked quantitative trait loci (QTL) female‐specific...