A5056653372- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Neurobiology and Insect Physiology Research
- Neuroendocrine regulation and behavior
- Chromium effects and bioremediation
- Olfactory and Sensory Function Studies
- Dietary Effects on Health
- Spaceflight effects on biology
- Hedgehog Signaling Pathway Studies
- Trace Elements in Health
- Adipose Tissue and Metabolism
- Developmental Biology and Gene Regulation
- Neuroscience, Education and Cognitive Function
- Physiological and biochemical adaptations
- Neuroinflammation and Neurodegeneration Mechanisms
- Heme Oxygenase-1 and Carbon Monoxide
- Porphyrin Metabolism and Disorders
- Epigenetics and DNA Methylation
- FOXO transcription factor regulation
- Heavy Metal Exposure and Toxicity
- Pharmacogenetics and Drug Metabolism
- Regulation of Appetite and Obesity
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pancreatic function and diabetes
- Invertebrate Immune Response Mechanisms
Wayne State University
2013-2023
Friedrich Miescher Institute
2010-2017
University of Basel
2016-2017
University of Hawaii System
2007
University of Zurich
1996-2007
University of California, San Francisco
2004
Dartmouth College
1990-1994
An insulin-like signaling pathway mediates the environmental influence on switch between C. elegans developmental programs of reproductive growth versus dauer arrest. However, specific role endogenous peptide (ILP) ligands in mediating these remains unknown. has 40 putative genes, many which are expressed sensory neurons and interneurons, raising intriguing possibility that ILPs encode different information to regulate entry into, exit from, These two switches can have regulatory...
Insulin-like peptides (ILPs) play highly conserved roles in development and physiology. Most animal genomes encode multiple ILPs. Here we identify mechanisms for how the forty Caenorhabditis elegans ILPs coordinate diverse processes, including development, reproduction, longevity several specific stress responses. Our systematic studies an ILP-based combinatorial code these phenotypes characterized by substantial functional specificity diversity rather than global redundancy. Notably, show...
The type of food source has previously been shown to be as important the level intake in influencing lifespan. Here we report that different Escherichia coli sources alter Caenorhabditis elegans These effects are modulated by subsets sensory neurons, which act with nmur-1, a homolog mammalian neuromedin U receptors. Wild-type is expressed somatic gonad, and interneurons, shortens lifespan only on specific E. sources—an effect dependent lipopolysaccharide structure. Moreover, type-dependent...
Significance Sensory inputs are known to control aging. The underlying circuitry through which these cues integrated into regulatory physiological outputs, however, remains largely unknown. Here, we use the taste sensory system of fruit fly Drosophila melanogaster detail one such circuit. Specifically, find that water-sensing signals alter nutrient homeostasis and regulate a glucagon-like signaling pathway govern production internal water production. This metabolic alteration likely serves...
Transient increases in mitochondrially-derived reactive oxygen species (ROS) activate an adaptive stress response to promote longevity. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases produce ROS locally various stimuli, and thereby regulate many cellular processes, but their role aging remains unexplored. Here, we identified the C. elegans orthologue of mammalian mediator ErbB2-driven cell motility, MEMO-1, as a protein that inhibits BLI-3/NADPH oxidase. MEMO-1 is complexed...
Hepatic 5-aminolevulinate (ALA) synthase, the first and rate-limiting enzyme in heme biosynthetic pathway, is known to be feedback repressed by end product of heme. We investigated whether regulates ALA synthase mRNA expression transcriptionally or post-transcriptionally primary cultures chick embryo hepatocytes. 2-Propyl-2-isopropylacetamide increased rate transcription gene, whereas an inhibitor biosynthesis, desferrioximine, had no effect on drug-induced rate. Heme decreased half-life...
Environmental fluctuations influence organismal aging by affecting various regulatory systems. One such system involves sensory neurons, which affect life span in many species. However, how neurons coordinate response to changes environmental signals remains elusive. Here, we found that a subset of shortens Caenorhabditis elegans ’ differentially regulating the expression specific insulin-like peptide (ILP), INS-6. Notably, treatment with food-derived cues or optogenetic activation...
Significance The ability of the worm Caenorhabditis elegans to taste or smell can influence its lifespan, and effect odors on lifespan has also been shown exist in fruit fly Drosophila . Now we provide evidence that is affected by taste: some inputs shorten whereas others increase it. In flies, lifespan-shortening act via an insulin-like signaling pathway downstream transcription factor dFOXO, lifespan-lengthening independently this pathway. unlikely linked changes food intake levels. Thus,...
An animal's survival strongly depends on its ability to maintain homeostasis in response the changing quality of external and internal environment. This is achieved through intracellular intercellular communication within among different tissues. One organ systems that plays a major role this maintenance nervous system. Here we highlight aspects neuronal inputs outputs pathways affect aging longevity. Accordingly, discuss how sensory influence lifespan modulation types signals, which...
Thioredoxins comprise a conserved family of redox regulators involved in many biological processes, including stress resistance and aging. We report that the C. elegans thioredoxin TRX-1 acts ASJ head sensory neurons as novel modulator insulin-like neuropeptide DAF-28 during dauer formation. show increased formation stress-resistant, long-lived larvae mutants for gene encoding requires acting neurons, upstream receptor DAF-2. Genetic rescue experiments demonstrate redox-independent functions...
EDITORIAL article Front. Genet., 27 June 2013 | https://doi.org/10.3389/fgene.2013.00124
Journal Article Two pathways for chromium(VI)-induced DNA damage in 14 day chick embryos: Cr—DNA binding liver and 8-0X0-2'-deoxyguanosine red blood cells Get access Manoj Misra, Misra Department of Chemistry, Dartmouth CollegeHanover, NH 03755, USA Search other works by this author on: Oxford Academic PubMed Google Scholar Joy A. Alcedo, Alcedo Karen E. Wetterhahn 1 1To whom correspondence should be addressed Carcinogenesis, Volume 15, Issue 12, December 1994, Pages 2911–2917,...
The ability of the carcinogen chromium(VI) to affect basal and zinc-inducible expression liver metailothionein was examined in 14- 18-day chicken embryos vivo. Metallothionein varied with stage embryo development, steady-state mRNA levels being approximately three times lower In livers versus 14-day embryos. Chromium(VI) treatment had no effect on metallothionein protein either or liver. Treatment zinc(II) resulted a 3- 5-fold increase Pre-treatment inhibited zinc(II)-induced by 30–50%....
An animal's responses to environmental cues are critical for its reproductive program. Thus, a mechanism that allows the animal sense and adjust environment should make more efficient physiology. Here, we demonstrate in Caenorhabditis elegans specific sensory neurons influence onset of oogenesis through insulin signaling response food-derived cues. The chemosensory ASJ modulate insulin-like peptide (ILP) INS-6. In contrast, other neurons, olfactory AWA, regulate food type-dependent...