A5015595885- HIV Research and Treatment
- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- HIV/AIDS drug development and treatment
- interferon and immune responses
- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Vascular Tumors and Angiosarcomas
- HIV/AIDS Research and Interventions
- Phagocytosis and Immune Regulation
- Eosinophilic Disorders and Syndromes
- Cancer Immunotherapy and Biomarkers
- Erythrocyte Function and Pathophysiology
- Herpesvirus Infections and Treatments
- CNS Lymphoma Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Viral Infections and Immunology Research
Hospices Civils de Lyon
2022-2024
Université Claude Bernard Lyon 1
2011-2023
Hôpital Lyon Sud
2022-2023
École Normale Supérieure de Lyon
2009-2022
Centre International de Recherche en Infectiologie
2015-2022
Inserm
2009-2015
Centre National de la Recherche Scientifique
2015
Virologie et Pathologies Humaines
2011-2012
Myeloid cells play numerous roles in HIV-1 pathogenesis serving as a vehicle for viral spread and reservoir. Yet, of this lineage generally resist infection when compared to other lineages, phenomenon particularly acute during the early phases infection. Here, we explore role APOBEC3A on these steps. is member APOBEC3 family that highly expressed myeloid cells, but so far lacks known antiviral effect against retroviruses. Using ectopic expression established cell lines specific silencing...
Click to increase image sizeClick decrease size Disclosure statementNo potential conflict of interest was reported by the author(s).
Monocyte-derived dendritic cells (MDDCs) play a key role in the regulation of immune system and are target numerous gene therapy applications. The genetic modification MDDCs is possible with human immunodeficiency virus type 1 (HIV-1)-derived lentiviral vectors (LVs) but requires high viral doses to bypass their natural resistance infection, this turn affects physiological properties. To date, single protein able counter restrictive phenotype, Vpx, derived from members HIV-2/simian SM...
ABSTRACT Type I interferons induce a complex transcriptional program that leads to generalized antiviral response against large panel of viruses, including human immunodeficiency virus type 1 (HIV-1). However, despite the fact negatively regulate HIV-1 ex vivo , chronic interferon state is linked progression AIDS and robust viral replication, rather than protection, in . To explain this apparent contradiction, we hypothesized may have evolved partial resistance interferon, test hypothesis,...
Kimura's disease (KD) is a rare and chronic eosinophilic related-disease, characterized by subcutaneous tissue masses, regional enlarged lymph nodes, hypereosinophilia elevated serum IgE. KD usually affects young adults in the Asian population. In Western countries, clinical biological presentation of often unknown, delaying diagnosis. Therapeutic management not standardized despite recent advances, remission from can be difficult to achieve, especially relapse situations.We report case an...
The block toward human immunodeficiency virus type 1 (HIV-1) infection of dendritic cells (DCs) can be relieved by Vpx (viral protein X), which degrades sterile alpha motif-hydroxylase domain (SAMHD1) or exogenously added deoxynucleosides (dNs), lending support to the hypothesis that SAMHD1 acts limiting deoxynucleoside triphosphates (dNTPs). This notion has, however, been questioned. We show while dNs and increase infectivity HIV-1, only latter restores a simian macaques variant, SIVMACΔVpx...
Myeloid cells are key targets of human immunodeficiency virus (HIV) replication in vivo and important players viral-induced pathogenesis. Albeit with variations depending on their differentiation status, these less susceptible to viral infection than other cell types like primary lymphocytes established lines ex vivo. This resistance is obviously exerted at multiple levels, yet a major restriction during lentiviral occurs the early steps infection, that is, those comprised between entry DNA...