A5100428266- Systemic Lupus Erythematosus Research
- Liver physiology and pathology
- Linguistic research and analysis
- Translation Studies and Practices
- Gut microbiota and health
- Linguistic Education and Pedagogy
- Digestive system and related health
- Dermatology and Skin Diseases
- Hepatitis C virus research
- Gastrointestinal motility and disorders
- Pancreatic and Hepatic Oncology Research
- Cytokine Signaling Pathways and Interactions
- Monoclonal and Polyclonal Antibodies Research
- Inflammasome and immune disorders
- Chronic Myeloid Leukemia Treatments
- Treatment of Major Depression
- Microbial Community Ecology and Physiology
- Urologic and reproductive health conditions
- Acne and Rosacea Treatments and Effects
- Postharvest Quality and Shelf Life Management
- Photodynamic Therapy Research Studies
- Curcumin's Biomedical Applications
- linguistics and terminology studies
- Garlic and Onion Studies
- Exercise and Physiological Responses
Tianjin University of Science and Technology
2025
Honghe University
2025
Xiangya Hospital Central South University
2024
Central South University
2024
Liaoning University
2007-2023
Zhangqiu City People's Hospital
2021-2022
Nanjing Medical University
2020-2022
Jinan University
2022
Nanjing Drum Tower Hospital
2022
First Affiliated Hospital of Xi'an Jiaotong University
2019
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease, which can cause endless suffering to the patients and severely impact their normal lives. To treat RA, drugs in use have many serious side effects, high cost, or only focus on anti-inflammatory mechanisms without taking joint lubrication into consideration. Therefore, this study, we aim construct novel anti-RA drug composed of hyaluronic acid/curcumin (HA/Cur) nanomicelle resolve these problems. Characterizations show...
MET alterations have been validated as a driven factor in NSCLC and gastric cancers. The c-Met inhibitors, capmatinib, tepotinib, savolitinib, are only approved for the treatment of harboring exon 14 skipping mutant MET. We used molecular hybridization conjunction with macrocyclization strategy structural optimization to obtain series 2-(2-(quinolin-6-yl)ethyl)pyridazin-3(2H)-one derivatives new inhibitors. One macrocyclic compounds, D6808, potently inhibited kinase MET-amplified Hs746T...
Probiotics, as health ingredients, have attracted widespread attention. However, due to the wide variety of probiotic species, their laxative effects and underlying mechanisms remain elusive. In this study, we investigated effect Bifidobacterium animalis subsp. lactis BLa80 (at concentrations 1.0 × 108, 2.0 4.0 108 CFU per mL, with a dosage 0.2 mL each) in mice, utilizing functional constipation mouse model induced loperamide hydrochloride (0.2 10 mg kg BW) for 7 consecutive days. Meanwhile,...
Citrus black rot caused by the pathogen Alternaria alstroemeriae severely affects growth and production of citrus industry. In order to further elucidate fruit in Yunnan Province, pathogenic fungi causing were identified through isolation purification, pathogenicity testing, morphological characteristics, rDNA ITS sequence analysis. Meanwhile, we synthesized curcumin-loaded nanoliposomes, a potential management approach control postharvest pathogen, conducted vitro vivo experiment...
Pancreatic cancer (PC) is a highly lethal that has strong ability for invasion and metastasis, poor prognosis, stubbornly high death rate due to late diagnosis early metastasis. Therefore, better understanding of the mechanisms metastasis should provide novel opportunities therapeutic purposes. As route in PC, perineural (PNI) occurs frequently; however, molecular mechanism PNI still poorly understood. In this study, we show hepatocyte growth factor (HGF)/c-Met pathway plays vital role PC....
Summary Background Sensitive scalp, one of the most frequent complaints among sensitive skin syndrome, has been described as abnormal and unpleasant sensory reactions scalp to environmental stimulus. However, symptoms are usually objective hard diagnose. Objective This study aimed reveal biophysical properties etiology scalp. Methods Sixty‐two healthy female subjects were enrolled divided into nonsensitive (NS) (SS) groups according questionnaires. Noninvasive instruments used measure...
Potato protease inhibitors (PPIs), as the main component of potato protein isolate, have good safety, nutrition and great market potential. The antioxidant anticancer properties PPIs were evaluated with cell-based biological assays. results showed that when concentration was 5 mg/mL, peroxyl radical scavenging value (2119 ± 204) mg VCE/100 g, cellular activity values (45.83 3.5) (no PBS wash) (33.25 4.4) µmol QE/100 g (PBS wash). Cells pretreated could significantly prevent oxidative damage...
Introduction Systemic lupus erythematosus (SLE) is a prototypic autoimmune disorder with variable clinical course, ranging from mild to severe forms. It mainly occurs in women, especially those of fertile age. The aim the study was systematically analyze associations perinatal disease activity adverse outcomes Chinese patients SLE and their off-spring. Material methods Data prenatal healthy pregnant woman admitted our hospital during period October 2001 January 2018 were retrospectively...
New-onset systemic lupus erythematosus (SLE) during pregnancy and in the postpartum period is rare, especially when complicated with pre-eclampsia, which difficult to diagnose accurately. Here, we report a patient new-onset SLE antiphospholipid syndrome pregnancy, presented as pre-eclampsia at admission.A 28-year-old primigravid woman was admitted our hospital 27th wk of gestation primary diagnosis severe pre-eclampsia. Although spasmolysis antihypertensive therapy were administered since...
The Hepatocyte Growth Factor Receptor (HGFR) c-Met is over-expressed and/or mutated in various human tumor types. Dysregulation of c-Met/HGF signaling pathway affects cell proliferation, survival and motility, leading to growth, angiogenesis, metastasis. Therefore, has become an attractive target for cancer therapy. This study aimed evaluate a new series 4-phenoxypyridine derivatives containing semicarbazones moiety its cytotoxicity. A novel 4-phenoxypyridines semicarbazone moieties were...
Purpose: A simple, sensitive and specific HPLC–MS/MS method was established to analysis the pharmacokinetics of CB1107 in mouses. Methods: selective, high-throughput liquid chromatography-tandem mass spectrometry (LC-MS-MS) has been developed validated for quantitative determination rat serum.Chromatographic separation achieved on a Zorbax Extend C18 Rapid Resolution HD column (4.6 mm × 50 mm, 1.8 μm). The temperature maintained at 35℃ flow rate 0.6 mL/min. Injection volume 20 μL. mobile...
Objective To investigate the efficacy and safety of transurethral seminal vesiculoscopy in diagnosis treatment intractable vesiculitis.
Depressive disorder is a common serious mental illness, with significant disability rate and mortality, which has caused burden to society family. At present, nearly half of the depressive patients are unable get effective treatment. In clinical practice, ketamine was widely observed alleviate symptoms effectively. However, its antidepressant mechanism not clear. Focusing on progresses in antidepressive ketamine, this review summarizes complex interaction about acute delayed effect puts...
Background: Small-for-size syndrome following liver surgery is characterized with compromised regeneration. Liver macrophage important to initiate regeneration, and modulation of immune microenvironment through may accelerate However, the role in regeneration still debated.Methods: Serum PD-L1 was detected after major hepatectomy minor humans rats. rats marked liver-to-body weight ratio kinetic growth rate, Ki67 PCNA, polarization accessed by iNOS, CD163 expression IHC iNOS/CD163 ratio. Rat...