A5087316150- Neurological Disease Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- Prostate Cancer Treatment and Research
- RNA modifications and cancer
- Cancer Research and Treatments
- Traditional Chinese Medicine Analysis
- Virus-based gene therapy research
- Cancer-related gene regulation
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer, Lipids, and Metabolism
- Molecular Biology Techniques and Applications
- Traditional Chinese Medicine Studies
- RNA Research and Splicing
- Lipid metabolism and disorders
- Genetic factors in colorectal cancer
- MicroRNA in disease regulation
- Drug-Induced Hepatotoxicity and Protection
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Bone health and treatments
- Gout, Hyperuricemia, Uric Acid
- Prostate Cancer Diagnosis and Treatment
- Circular RNAs in diseases
- Metabolomics and Mass Spectrometry Studies
Jiangsu University
2014-2024
Affiliated Hospital of Jiangsu University
2011-2024
Beijing Jishuitan Hospital
2024
Peking University
2024
Capital Medical University
2024
Kunming Medical University
2024
Anhui University of Traditional Chinese Medicine
2007-2023
The First People's Hospital of Changde
2021-2023
Kunming University of Science and Technology
2018
Central People's Hospital of Zhanjiang
2018
Persistent infection with high-risk human papillomavirus (HR-HPV) plays a key role in the onset of cervical cancer. This study was designed to examine epidemiological trends and genotype distribution HPV from 2014 2023 plateau region Southwest China. The findings could offer valuable insights for clinical screening cancer formulation vaccination policies. retrospective analyzed 66,000 women who received HPV-DNA testing at First People's Hospital Qujing, Yunnan, China, between 2023. cohort...
Background Prostate cancer (PCa) is one of the most malignant tumors male urogenital system. There an urgent need to identify novel biomarkers for PCa. Methods In this study, we evaluated expression levels MCM10 in prostate by analyzing public datasets (including The Cancer Genome Atlas and GSE21032). Furthermore, loss function assays was performed evaluate effects on cell proliferation, apoptosis, colony formation. microarray bioinformatics analyses explore potential mechanisms MCM10....
Prostate cancer (PCa) is one of the most frequently diagnosed types worldwide. However, there remains a lack accurate biomarkers to predict outcome PCa. Non-SMC condensin I complex subunit H (NCAPH) encodes regulatory non-structural maintenance chromosomes complex. The present study aimed investigate whether NCAPH may be novel diagnostic marker for PCa by analyzing public datasets, including GSE17951, GSE55945 and dataset from Cancer Genome Atlas. current results, best our knowledge,...
Prostate cancer (PCa) is the most frequently diagnosed type of in Chinese males. Cell-cycle aberration a hallmark cancer. Spindle pole body component 25 homolog (SPC25), Ndc80 complex, serves an important role regulating mitotic chromosome segregation. However, functional roles SPC25 PCa remain poorly understood. To best our knowledge, present study was first to demonstrate that significantly upregulated PCa. In order investigate molecular SPC25, loss function assay performed, revealing...
To determine the potential association between triglyceride-glucose (TyG) index and bone mineral density (BMD) in community-dwelling adults without diabetes using a nationally representative database from United States (US).
We investigated the mechanism of action silymarin in a mouse model renal ischemia-reperfusion injury (I/R) to ascertain its role treatment I/R injury.Twenty-four C57BL/6 male mice were divided randomly into three groups: control (sham); (I/R); + (silymarin I/R). In sham mice, an abdominal incision was made, followed by dissection bilateral pedicle, with no further cross-clamping arteries. Silymarin administered 100 mg/kg daily for 7 consecutive days before surgery, whereas (i.g.) 0.9 %...
Spindle pole body component 25 (SPC25) is a of NDC80 complex that controls spindle assembly checkpoint in the microtubule-binding domain kinetochores. We recently showed SPC25 required for prostate cancer (PrC) cell proliferation and cycle progression, here we investigated whether may be Cancer stem (CSC) marker PrC. found levels were higher PrC samples than paired normal tissue. The overall survival patients with high was poorer those low SPC25. lines transduced two vectors carrying...
Abstract Objective To investigate the relationship and interaction of single nucleotide polymorphisms (SNPs) KLK3 VDR environmental factors with predisposition to prostate cancer within Chinese population. Methods The comparison between 108 patients 242 healthy people was carried out by using TaqMan/MGB Probe Technology determine genotypes KLK3(rs2735839 is located KLK2 KLK3) (rs731236 exon 9). Univariate multivariate logistic regression model were used assess connection genetic risk PCa...
Circular RNAs (circRNAs) is one type of non-coding (ncRNAs) which have many roles in biological processes, as well modulation intracellular gene expression modulation.Nonethless, the along with status most circRNAs NSCLC (non-small cell lung cancer) remain unknown.Herein, we conducted a high-throughput microarray sequencing to identify abnormal expressed circRNAs.Circ0101675 was found upregulated lines and tissues.We carried out colony formation, transwell, CCK-8, animal assays investigate...
We investigated the activity of loureirin B against liver fibrosis and underlying molecular mechanisms.
Tumor-associated macrophages (TAMs) are involved in the growth of prostate cancer (PrC), while molecular mechanisms underlying interactive crosstalk between TAM and PrC cells remain largely unknown. Platelet-derived factor (PDGF) is known to promote mesenchymal stromal cell chemotaxis tumor microenvironment. Recently, activation spindle pole body component 25 (SPC25) has been shown proliferation associated with stemness. Here, relationship SPC25 PDGF was investigated. Significant increases...
We recently engineered an oncolytic adenovirus (PPE3-SEA) that expresses the superantigen, Staphylococcus enterotoxin A (SEA), and has enhanced tumor specificity because telomerase reverse transcriptase hypoxia-inducible factor promoters regulate expression of E1A E1B genes, respectively. Here, we evaluated PPE3-SEA anti-tumor activity against MB49 mouse bladder cancer cell proliferation in vitro vivo. infection murine cells induced cytopathic effects, significant SEA mRNA protein, as...
To explore the recent 20 years' herbal administration rules in TCM treatments of ovarian cysts (OCs) based on data mining. A prescription database for was established by ACCESS 2007. Importing into SPSS17.0 and SPSS Modeler14.1. used descriptive cluster analyses, while Modeler14.1 association analysis. After screening, 363 prescriptions were obtained. The 10 most frequently-used Chinese medicines are Zedoaria (Rhizoma Curcumae), Poria cocos (Poria), Common buried rubber Sparganii), Red peony...
Aberrant growth and polarization of microglia are critical for pathological initiation progression neurodegenerative conditions like Alzheimer's disease (AD). However, the molecular signals that govern outgrowth have not yet been fully determined. Spindle pole body component 25 (SPC25) is an important part forming NDC80 complex, which plays a key role in assembly microtubule-binding domain kinetochores. Nevertheless, SPC25 microglial during neurodegeneration has described before, was thus...
Background: Globally, lung adenocarcinoma (LUAD) is the most common type of cancer. The secreted protein angiopoietin-like 4 (ANGPTL4) has been implicated in a number physiological and pathological processes, including angiogenesis lipid metabolism. But role ANGPTL4 LUAD remains unknown. Methods: expression miR-133a-3p was confirmed by public database analysis. Xenograft model, MTT, Clone formation EdU analysis were used to confirm effects miR-133a-3p/ANGPTL4 on cell proliferation growth....
Prostate cancer (PCa) is considered to be one of the most common tumors in men. Calcium‑binding and coiled‑coil domain 2 (CALCOCO2) a known important xenophagy receptor, which mediates intracellular bacterial degradation. To best authors' knowledge, present study first demonstrate that CALCOCO2 functions as an oncogene PCa. The results current indicated knockdown suppressed cell proliferation colony formation, whereas it promoted apoptosis PCa cells. In addition, cells reduced cyclin‑E1...
Abstract Objectives: Bone metastasis is the leading cause of death in patients with advanced prostate cancer (PCa). The present study aimed to construct a prognostic risk model based on bioinformatics methods that can predict bone cancer, and investigated effect scores prognosis immune infiltration. Methods: Differentially expressed genes (DEGs) were identified metastases primary PCa samples intersected BMP-related from MisigDB database. Then LASSO regression analysis was used establish...