A5085947874- Viral Infections and Immunology Research
- Cervical and Thoracic Myelopathy
- Spine and Intervertebral Disc Pathology
- Viral Infectious Diseases and Gene Expression in Insects
- Insect Resistance and Genetics
- Spinal Fractures and Fixation Techniques
- Viral gastroenteritis research and epidemiology
- Cytomegalovirus and herpesvirus research
- Entomopathogenic Microorganisms in Pest Control
- Medical Imaging and Analysis
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Animal Virus Infections Studies
- RNA Research and Splicing
- Hepatitis Viruses Studies and Epidemiology
- Chinese history and philosophy
- Plant Virus Research Studies
- Circular RNAs in diseases
- Spinal Cord Injury Research
- Advanced Neuroimaging Techniques and Applications
- Musculoskeletal pain and rehabilitation
- Virus-based gene therapy research
- MicroRNA in disease regulation
- RNA regulation and disease
- Bone and Joint Diseases
Jiangsu University
2015-2024
Renji Hospital
2016-2023
Shanghai Jiao Tong University
2020-2023
Affiliated Hospital of Jiangsu University
2021-2022
Yangzhou University
2022
Shanghai Micro Satellite Engineering Center
2020
Sichuan Agricultural University
2018
Changhai Hospital
2003-2016
Second Military Medical University
2003-2016
St. Paul's Hospital
2015
A potential bone tissue engineering material was produced from a biodegradable polymer, poly(lactic-co-glycolic acid) (PLGA), loaded with nanodiamond phospholipid compound (NDPC) via physical mixing. On the basis of hydrophobic effects and absorption, we modified original hydrophilic surface (NDs) phospholipids to be amphipathic, forming typical core–shell structure. The ND-phospholipid weight ratio optimized generate sample NDPC50 (i.e., ND–phospholipid 100:50), able dispersed in PLGA...
Study Design. Prospective cohort. Objective. To explore the correlations between diffusion tensor imaging (DTI) ratios and tractography (DTT) grading with clinical symptoms outcomes of cervical spondylotic myelopathy (CSM). Summary Background Data. In addition to magnetic resonance (MRI) computed tomography, DTI may be useful in understanding pathophysiology spinal cord earlier stages CSM but it confounded by age level, previous studies had small sample sizes. Methods. Controls (n = 36)...
Abstract Recombination of Hepatitis E Virus (HEV) has rarely been reported. In the present study, phylogenetic and recombination analyses were performed on 134 complete HEV genomes. Three potentially significant events, including both intra-genotype one inter-genotype, identified by detection analysis. events I II occurred respectively, among three isolates, lineage represented CHN-XJ-SW13 (GU119961, swine isolate), E067-SIJ05C (AB369690, human JJT-Kan (AB091394, lead to recombinant isolate...
Coxsackie virus B3 (CVB3), an enterovirus, is the main pathogen causing viral myocarditis, pericarditis, hepatitis and other inflammation-related diseases. Non-coding RNAs with a closed loop molecular structure, called circular (circRNAs), have been shown to be involved in multiple virus-related processes, but roles mechanisms CVB3 infection not systematically studied. In this study, when HeLa cells were infected CVB3, expression of hsa_circ_0000367 (circSIAE) was significantly decreased as...
Background/Aims: Helicobacter pylori (H. pylori) infection is closely related to human gastric mucosa-associated diseases. Several recent studies on miRNAs have expanded our insights H.pylori pathogenesis. This study aimed investigate the biological roles and underlying molecular mechanisms of miR-29a-3p in cells tissues with infection. Methods: expression was quantified by quantitative RT-PCR (qRT-PCR). A target gene validated bioinformatics analysis, western blotting dual luciferase...
Chronic spinal cord compression is the result of mechanical pressure on cord, which in contrast to traumatic injury, leads slowly progressing nerve degeneration. These two types injuries may trigger similar mechanisms, including motoric cell apoptosis and autophagy, however, depending differences underlying injury severity, reactions predominantly involve conservation function or initiation functions for removal irreversibly damaged cells. p62 a multidomain adapter protein, involved survival...
CVB3 (coxsackievirus 3) is a primary causal agent of viral myocarditis. Emodin natural compound isolated from certain plant roots. In the present study, we found that emodin inhibited replication in vitro and mice, now report an unrecognized mechanism by which inhibits through suppression protein translation via multiple pathways. On one hand, treatment Akt/mTOR (mammalian target rapamycin) signalling activated 4EBP1 (eukaryotic initiation factor 4R-binding 1), leading to ribosomal L32...
Abstract In attempts to improve the selectivity and sensitivity of steroid separation determine their migration order, a comparison use anionic cationic surfactants based on MEKC sweeping‐MEKC modes was made. A mixture six steroids (progesterone, 17‐hydroxy progesterone, 11‐deoxycortisol, corticosterone, cortisone, cortisol) could be separated detected by means CE/UV‐absorption method. The order time for these compared under various conditions, including acidic/alkaline buffers,...
All lepidopteran baculovirus genomes sequenced encode a homolog of the Bombyx mori nucleopolyhedrovirus orf61 gene ( Bm61 ). To determine role in baculoviral life cycle, we constructed knockout virus and characterized it cells. We observed that deletion bacmid led to defect production infectious budded (BV). Quantitative PCR analysis BV media culturing transfected cell indicated was not produced due deletion. Electron microscope showed , nucleocapsids were transported from nucleus cytoplasm....
Conventional localization technique of V point for full-endoscopic posterior cervical foraminotomy and discectomy (FPCD) required repeated fluoroscopies, especially in patients with short thick necks. To address this issue, the present study aimed to introduce a new point, further evaluate its efficacy.A K-wire was inserted fixed at pedicle eye under A/P fluoroscopy, then working channel established quickly along it. Thirty-four who underwent minimally invasive FPCD assisted by were included...
Infectious hypodermal and hematopoietic necrosis virus (IHHNV) is one of the most recurrent viral pathogens infecting penaeid shrimps. Although previous reports showed that genomic recombination happened among different IHHNV strains, no study has been carried out to systematically elucidate such recombination. In this study, we performed phylogenetic analysis available complete genomes sequences in GenBank. We have found two intra‐group between lineages III II infectious group,...
Coxsackie B3 virus (CVB3) is a member of small RNA viruses that belongs to the genus Enterovirus family Picornaviridae and CVB3 main pathogen acute chronic viral myocarditis. In this study RT-qPCR was used determine expression miR-107 in CVB3-infected uninfected HeLa cells. The experimental results show level began rise at 4 h after infection, significantly boosted 6 h. Based on experiment, we consider related infection. order further clarify effect process studied upstream downstream target...