A5086466832- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Epigenetics and DNA Methylation
- Genetic factors in colorectal cancer
- Multiple and Secondary Primary Cancers
- Prostate Cancer Treatment and Research
- Metastasis and carcinoma case studies
- Cancer, Lipids, and Metabolism
- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Cancer survivorship and care
- Esophageal Cancer Research and Treatment
- Cancer Immunotherapy and Biomarkers
- DNA Repair Mechanisms
- Hormonal and reproductive studies
- Lung Cancer Treatments and Mutations
- Peptidase Inhibition and Analysis
- Cancer Research and Treatments
- Ferroptosis and cancer prognosis
- Hemoglobinopathies and Related Disorders
- Patient Dignity and Privacy
- Childhood Cancer Survivors' Quality of Life
- PARP inhibition in cancer therapy
- Cancer, Stress, Anesthesia, and Immune Response
- Heat shock proteins research
Florida Cancer Specialists & Research Institute
2019-2024
University of Rochester
2013-2018
University of Rochester Medical Center
2013-2018
Strong Memorial Hospital
2016
National Taiwan University
2016
Harvard University
2006-2015
Dana-Farber Cancer Institute
2010-2014
Sidney Kimmel Cancer Center
2014
Dana-Farber Brigham Cancer Center
2012
Brigham and Women's Hospital
2012
Participation of women in the medical profession has increased during past four decades, but issues concern persist regarding disparities between sexes academic medicine. Advancement is largely driven by peer-reviewed original research, so we sought to determine representation female physician-investigators among authors selected publications 35 years.
Cisplatin-based chemotherapy is the standard of care for patients with muscle-invasive urothelial carcinoma. Pathologic downstaging to pT0/pTis after neoadjuvant cisplatin-based associated improved survival, although molecular determinants cisplatin response are incompletely understood. We performed whole-exome sequencing on pretreatment tumor and germline DNA from 50 carcinoma who received followed by cystectomy (25 "responders," 25 pT2+ "nonresponders") identify somatic mutations that...
Objective To describe the management strategies and outcomes of patients with renal medullary carcinoma ( RMC ) characterise predictors overall survival OS ). Patients Methods is a rare aggressive malignancy that afflicts young sickle cell trait; there are limited data on to date. This study who were treated in 2000–2015 at eight academic institutions North America France. The Kaplan–Meier method was used estimate , measured from initial diagnosis date death. Cox regression analysis...
While fibroblast growth factor receptor 3 (FGFR3) is frequently mutated or overexpressed in nonmuscle-invasive urothelial carcinoma (UC), the prevalence of FGFR3 protein expression and mutation remains unknown muscle-invasive disease. mRNA expression, mutational status, copy number variation were retrospectively analyzed 231 patients with formalin-fixed paraffin-embedded primary UCs, 33 metastases, 14 paired metastatic tumors using following methods: immunohistochemistry, NanoString...
$('.header-date').hide();$('#titleAuthors').hide();$('#abstractHeader').hide(); Iawen Hsu 1 * , Chiuan-Ren Yeh Spencer Slavin Hiroshi Miyamoto 2 George J. Netto Yu- Chieh Tsai Mesut Muyan 3 Xue-Ru Wu 4 Edward M. Messing Elizabeth A. Guancial 5 Shuyuan Departments of Urology and Pathology, University Rochester Medical Center, Rochester, NY 14642. Urology, Oncology, The Johns Hopkins Hospital, Baltimore, MD 21231. Department Biochemistry & Biophysics, New York University, School Medicine,...
Metastatic urothelial carcinoma of the bladder is associated with multiple somatic copy-number alterations (SCNAs). We evaluated SCNAs to identify predictors poor survival in patients metastatic treated platinum-based chemotherapy.We obtained overall (OS) and array DNA data from two cohorts. Associations between recurrent OS were determined by a Cox proportional hazard model adjusting for performance status visceral disease. mRNA expression was potential candidate genes NanoString nCounter...
The prostate cancer (PCa) microenvironment contains active stromal cells known as cancer-associated fibroblasts (CAF) that may play important roles in influencing tumor progression. Here we studied the role of CAF estrogen receptor alpha (ERα) and found it could protect against PCa invasion. Immunohistochemistry on prostatectomy specimens showed patients with ERα-positive stroma had a significantly lower risk for biochemical recurrence. In vitro invasion assays further confirmed ERα was able...
Abstract We evaluated primary tumors from two cohorts, Spain ( N = 111) and Greece 102), for patients who were treated with platinum‐based chemotherapy. Patients tested HER2 status IHC score of 3+ or FISH ratio ≥2.2) by immunohistochemistry ), fluorescence in situ hybridization DNA copy number, mRNA expression, mutation metastatic urothelial carcinoma UC its impact on survival. ERBB2 was determined hotspot sequencing. expression assessed using NanoString counting. Association overall...
No AccessJournal of UrologyAdult Urology1 Sep 2014Impact Bladder Cancer on Health Related Quality Life in 1,476 Older Americans: A Cross-Sectional Study Chunkit Fung, Chintan Pandya, Elizabeth Guancial, Katia Noyes, Deepak M. Sahasrabudhe, Edward Messing, and Supriya G. Mohile FungChunkit Fung Division Medical Oncology, University Rochester Center, Rochester, New York More articles by this author , PandyaChintan Pandya Department Public Sciences, School Medicine Dentistry, GuancialElizabeth...
Abstract Background The authors evaluated mocetinostat (a class I/IV histone deacetylase inhibitor) in patients with urothelial carcinoma harboring inactivating mutations or deletions CREB binding protein [ CREBBP ] and/or E1A p300 EP300 acetyltransferase genes a single‐arm, open‐label phase 2 study. Methods Eligible platinum‐treated, advanced/metastatic disease received oral (at dose of 70 mg 3 times per week [TIW] escalating to 90 TIW) 28‐day cycles 3‐stage study (ClinicalTrials.gov...
A randomised study to assess the addition of apatorsen, an antisense oligonucleotide that inhibits Hsp27 expression, docetaxel in patients with metastatic urothelial carcinoma (mUC) relapsed after prior platinum-based chemotherapy. Multicentre, phase II 1:1 randomisation apatorsen (three loading doses at 600 mg intravenous followed by weekly doses) plus (75 mg/m2 every 21 days) (A/D) or alone. Overall survival (OS) was primary end point a P value <0.1 (one-sided) being positive....
Abstract Chaperone protein quantity may regulate the balance of proteins involved in invasion and malignancy. BAG3 is a co‐chaperone pro‐survival that has been implicated adhesion, migration, metastasis. We reported overexpression MDA435 human breast cancer cells results significant decrease migration adhesion to matrix molecules reversed upon deletion proline‐rich domain (dPXXP). now hypothesize transcriptional analysis would identify matrix‐related processes are regulated by and/or its...
Neoadjuvant cisplatin-based chemotherapy (NAC; 70 mg/m2) is standard of care for muscle-invasive bladder carcinoma (MIBC). Many patients (pts) cannot receive cisplatin because renal impairment, and administration 35 mg/m2 on day 1 + 8 or 2 (i.e., split schedule) a commonly used alternative. In this retrospective analysis, we compared complete (pT0) partial (<pT2) pathologic response rates between schedule (SS) conventional (CS) pts, after 1:1 matching regimen, number cycles, tumor histology,...
// Chiuan-Ren Yeh 1, 2 , Zheng-Yu Ou 1 Guang-Qian Xiao Elizabeth Guancial 3 Shuyuan Department of Urology, University Rochester Medical Center, Rochester, NY 14642, USA Pathology, Medicine, Correspondence to: Yeh, e-mail: shuyuan_yeh@urmc.rochester.edu Keywords: ERβ, RCC, metastasis, DAB2IP, CD4+ T cells Received: August 12, 2015 Accepted: October 13, Published: November 17, ABSTRACT Previous studies indicated the cells, one most common types immune existing in microenvironment renal cell...
TPS3169 Background: Aryl Hydrocarbon Receptor (AHR) is a ligand-activated transcription factor that regulates the activity of multiple innate and adaptive immune cells. Kynurenine, generated from tryptophan by IDO1 TDO2, ligand binds AHR leads to net immunosuppressive tumor microenvironment, making an attractive therapeutic target in cancer types. IK-175 selective, small molecule inhibitor being developed as oral agent. In preclinical mouse models, demonstrates antitumor single agent or...