A5011698495- Renal cell carcinoma treatment
- Acute Lymphoblastic Leukemia research
- Bacterial Identification and Susceptibility Testing
- Bone Tumor Diagnosis and Treatments
- Blood disorders and treatments
- Childhood Cancer Survivors' Quality of Life
- Neutropenia and Cancer Infections
- Advanced Radiotherapy Techniques
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Sarcoma Diagnosis and Treatment
- MRI in cancer diagnosis
- Radiation Therapy and Dosimetry
- IgG4-Related and Inflammatory Diseases
- Hemophilia Treatment and Research
- Hedgehog Signaling Pathway Studies
- Rabbits: Nutrition, Reproduction, Health
- Histiocytic Disorders and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Testicular diseases and treatments
- Microtubule and mitosis dynamics
- Reproductive Physiology in Livestock
- Breast Cancer Treatment Studies
- Autoimmune Neurological Disorders and Treatments
- Hemoglobinopathies and Related Disorders
- Hematopoietic Stem Cell Transplantation
UMass Memorial Health Care
2024
University of Massachusetts Chan Medical School
2020-2021
Children's Medical Center
2020
Children's Hospital & Medical Center
2011-2019
University of Nebraska Medical Center
2016-2019
Monroe Carell Jr. Children's Hospital
2011-2016
Vanderbilt University
2011
Vanderbilt University Medical Center
2010
Oregon Health & Science University
2007-2009
Doernbecher Children's Hospital
2009
Objective To describe the management strategies and outcomes of patients with renal medullary carcinoma ( RMC ) characterise predictors overall survival OS ). Patients Methods is a rare aggressive malignancy that afflicts young sickle cell trait; there are limited data on to date. This study who were treated in 2000–2015 at eight academic institutions North America France. The Kaplan–Meier method was used estimate , measured from initial diagnosis date death. Cox regression analysis...
Abstract Background Transient hyperglycemia (TH) is a recognized side effect of the corticosteroids and asparaginase given during induction chemotherapy for pediatric acute lymphoblastic leukemia (ALL). Information needed about how TH has been impacted by changes in ALL therapy. This study examined prevalence cohort patients impact on type steroid or used risk factors such as age, gender, overweight. Methods Retrospective record review aged 2–18 years diagnosed with 1999–2006. was defined ≥2...
Event-free survival for recurrent alveolar rhabdomyosarcoma (ARMS) is poor, and a consensus approach to treatment in the relapse setting has not been established. Recent studies suggest that combination regimen of vincristine, irinotecan, temozolomide (VITA) active against sarcomas. We present our single-institution experience with this relapsed ARMS heavily pretreated patients, including those prior exposure vincristine irinotecan. observed complete radiographic response 1 4 patients who...
Abstract Late hemorrhagic disease of the newborn (HDN) presents 0.5–6 months after birth with mucocutaneous and intracranial bleeding. We describe here two cases late HDN in infants who received vitamin K. The first case is a previously healthy breastfed male one dose oral K at developed an hemorrhage 5 weeks later. He was treated intravenous recombinant factor VIIa prior to emergent craniectomy. An unrelated infant presented age diarrhea easy bruising despite IM birth. These illustrate...
Frequent surveillance of bacterial pathogens responsible for microbiologically defined-blood stream infections (MD-BSI), and their respective antibiotic susceptibilities is central to tailoring empiric therapy in febrile neutropenia (FN) episodes pediatric patients with leukemia. The safety deescalating leukemia incompletely understood.A retrospective chart review 194 FN occurred between the years 2013 2016 67 Clinical microbiologic data were recorded.MD-BSI 36 (18%) episodes. Deescalation...
The incidence of bacteremia at the onset pediatric febrile neutropenia (FN) 2 academically linked institutions was 9.84%, and subsequent blood cultures performed for children with persistent FN yielded an 4.21%. Until risk factors new-onset in patients being treated can be identified diagnostic methods improved, compliance national guidelines is recommended.
Abstract Background Pediatric acute lymphoblastic leukemia (ALL) therapies have been associated with many late effects, including obesity, hyperglycemia, and insulin resistance. Few data are available linking these abnormalities to specific risk factors present during ALL treatment. Methods Retrospective cohort study prospective follow‐up. Subjects had diagnosed at ages 1–18 years off chemotherapy for >9 months. Oral glucose tolerance testing (OGTT) was performed results compared...
Changes in diet quality may be as important changes energy availability the reproductive success of small mammals. The effect dietary protein on fitness females is most likely mediated by yield or composition milk. Mus musculus was used a model to test whether restriction leads milk composition. Primiparous mice were fed 10% 20% casein-based through 2 consecutive attempts. There no food consumption litter size. However, reduction led production with 12% decrease content and decreased both...
OBJECTIVE. Abdominopelvic CT is often performed in children with Wilms tumor or hepatoblastoma. However, the reported incidence of recurrent disease involving pelvis low. This study explores impact abdominopelvic on MATERIALS AND METHODS. A text word database search our radiology information system for terms “Wilms” and “hepatoblastoma” was time interval between 1999 2009. The inclusion criterion performance CT. Tumor stage metastases at presentation, follow-up, patient care were extracted...
Dinutuximab is a monoclonal antibody administered to patients with high-risk neuroblastoma, usually after an autologous stem cell transplant. associated immune mediated and neurologic toxicities, but fatal adverse events are rare. A case presented of neuroblastoma development encephalopathy shortly the first course dinutuximab. The patient had extensive evaluation for etiology symptoms received aggressive interventions, ultimately expired. Postmortem diagnosis anti–N-methyl D-aspartate...
438 Background: RMC is a rare and aggressive neoplasm that afflicts primarily young black patients with sickle cell trait. Our primary objective to report the outcomes of through collaborative initiative. Methods: After IRB approval, we retrospectively reviewed records treated from 2000-2013 at 7 academic institutions. Overall survival (OS) was calculated diagnosis date death. Descriptive statistics were used. Results: A total 39 included. Median age 27.8 years 29 (74%) males. 38 (97%) had...
e16111 Background: Renal medullary carcinoma (RMC) is a rare and aggressive malignancy that afflicts young patients with sickle cell trait. Data regarding patient management outcomes are limited. Our objective to evaluate the strategies of RMC characterize predictors overall survival (OS). Methods: This retrospective, multi-institutional study who were treated during 2000-2015 at eight academic institutions in North America France. The Kaplan-Meier method was used estimate OS, which measured...
We report a case of 2-year-old girl who was diagnosed with natural killer cell acute lymphoblastic leukemia and treated an chemotherapy regimen. Two months posttherapy, the disease relapsed myeloid immunophenotype. Complete response then achieved therapy followed by unrelated donor umbilical cord allogenic stem transplant. Retrospectively, reanalysis diagnostic specimen showed minimal myeloperoxidase expression that called negative conventional single parameter linear gating but better...
Radiation therapy continues to be an important treatment application in pediatric oncology.There have been significant improvements the of radiation past decade which can directly applied children and improve patient outcome relative tumor control ameliorate late effects management imposed on normal tissue.In this paper we present using volume modulation arc a unique presentation Ewing sarcoma.Multiple body segments were treated simultaneous manner with conformal avoidance critical tissues...
Radiation therapy remains important in the modern management of both Hodgkin and non-Hodgkin lymphoma. is applied as consolidation post chemotherapy primary for selected limited volume clinically favorable histology. Application techniques permits more sparing normal tissue all anatomical locations. Modern image guidance security daily patient treatment set up strategic titration planning target to further spare tissue. Four-dimensional makes certain targets are fully treated phases...