A5002627503- Cervical Cancer and HPV Research
- Cancer-related molecular mechanisms research
- Dysphagia Assessment and Management
- Voice and Speech Disorders
- Tracheal and airway disorders
- Head and Neck Cancer Studies
- interferon and immune responses
- Radio Wave Propagation Studies
- Virus-based gene therapy research
- Knee injuries and reconstruction techniques
- Advanced Frequency and Time Standards
- Speech Recognition and Synthesis
- Spatial Neglect and Hemispheric Dysfunction
- Trauma Management and Diagnosis
- Hernia repair and management
- Photonic and Optical Devices
- Respiratory viral infections research
- Orthopedic Surgery and Rehabilitation
- Genetic factors in colorectal cancer
- Cancer-related Molecular Pathways
- Surgical site infection prevention
- Lightning and Electromagnetic Phenomena
- T-cell and Retrovirus Studies
- Millimeter-Wave Propagation and Modeling
- Scientific Research and Discoveries
University of Wisconsin–Madison
1992-2025
Vanderbilt University
2022
Google (United States)
2022
UW Health University Hospital
2021
Baylor College of Medicine
1993
Technical University of Denmark
1974-1975
The records of 101 patients who had undergone chest wall reconstruction both with and without stabilization the by Marlex mesh were reviewed to see if reduced ventilator dependence hospital stay, determine whether use was associated any increased risk infection. In 40 in whom used, mean number days on postoperative support 0.8, stay 9.7 days. 61 not 4.9, 17.5 These differences statistically significant (p = 0.03, p 0.006). Two Marlex-stabilized group (5%) developed wound infections, but...
Abstract Squamous cell carcinoma (SCC) development in mammals is thought to require months or years from the time that initial changes occur. We show SCCs induced by mouse papillomavirus MmuPV1, which are generally diagnosed 4-6 post infection, can be found as soon 2 weeks infection. developed within immune-competent, adult FVB (FVB/NTac) mice at sites prone human (HPV)-induced tumors and cancers patients: base of tongue, anus, skin. The anterior less susceptible than tongue HPV-induced...
Human head and neck cancers that develop from the squamous cells of oropharynx (Oropharyngeal Squamous Cell Carcinomas or OPSCC) are commonly associated with papillomavirus infection. A infection-based mouse model oropharyngeal tumorigenesis would be valuable for studying development treatment these tumors. We have developed an efficient system using (MmuPV1) to generate dysplastic lesions, including tumors, in soft palate base tongue two immune-deficient strains mice. To maximize efficiency...
Recurrent respiratory papillomatosis (RRP), caused by laryngeal infection with low-risk human papillomaviruses, has devastating effects on vocal communication and quality of life. Factors in RRP onset, other than viral presence the airway, are poorly understood. research been stalled limited preclinical models. The only known papillomavirus able to infect laboratory mice, Mus musculus (MmuPV1), induces disease a variety tissues. We hypothesized that MmuPV1 could larynx as foundation for...
This is one of a series mini-reviews prepared by the IEEE Wave Propagation Standards Committee to assist those persons who are unfamiliar with topic and need current overview art. particular paper reviews measuring wave-tilt groundwaves establish properties uppermost ground.
Voice rest is frequently prescribed after phonosurgery, but optimal type and duration for voice outcomes have not been demonstrated. Studies to date characterized by heterogeneity in surgical procedures laryngeal diagnoses. We sought analyze the effect of recommended absolute on microflap surgery benign vocal fold lesions. A secondary purpose was identify patient factors associated with postoperative outcomes.Forty-three patients were included this retrospective review aged 18 years above...
ABSTRACT Epidermodysplasia verruciformis (EV) is a rare genetic skin disorder that characterized by the development of papillomavirus-induced lesions can progress to squamous cell carcinoma (SCC). Certain high-risk, cutaneous β-genus human papillomaviruses (β-HPVs), in particular HPV5 and HPV8, are associated with inducing EV individuals who have homozygous mutation one three genes tied this disease: EVER1 , EVER2 or CIB1. also known as TMC6 TMC8, respectively. Little about biochemical...
Development of invasive cancer in mammals is thought to require months or years after initial events such as mutation viral infection. Rarely, cancers regress spontaneously. We show that can develop and on a timescale weeks, not years. Invasive squamous cell carcinomas developed normal adult, immune-competent mice soon 2 weeks infection with mouse papillomavirus MmuPV1. Tumor development, regression persistence was tissue- strain-dependent. Cancers infected rapidly at sites also prone...
Clinicians commonly recommend increased hydration to patients with voice disorders. However, effects on clinical outcome measures have been inconsistent. Hydration-induced change within different layers of vocal fold tissue is currently unknown. Magnetic Resonance Imaging (MRI) a promising method noninvasively measuring water content in folds. We sought image and quantify changes mucosa thyroarytenoid muscle after dehydration rehydration. Excised porcine larynges were imaged using proton...
The artemisinin family of compounds is cytopathic in certain cancer cell lines that are positive for human papillomaviruses (HPV) and can potentially drive the regression dysplastic lesions. We evaluated efficacy topical dihydroartemisinin (DHA) on cervical dysplasia anal two papillomavirus mouse models: K14E6/E7 transgenic mice, which express HPV16 oncogenes; immunodeficient NOD/SCID gamma (NSG) mice infected with Mus musculus (MmuPV1). Mice started treatment DHA at 25 weeks age (K14E6/E7)...
Purpose Patients undergoing vocal fold procedures significantly reduce but often do not cease voice use during absolute postprocedure rest. We hypothesized that patients who completed preprocedure therapy would increase adherence to Method Eighty-six participants this prospective cohort study. scheduled for office-based procedures, 1–3 days of rest, and speech-language pathology (SLP) care were recruited. SLP consisted either (a) multiple sessions, (b) one counseling/therapy session, or (c)...
Objective Mouse papillomavirus MmuPV1 causes both primary and secondary infections of the larynx in immunocompromised mice. Understanding lateral vertical transmission to would benefit patients with recurrent respiratory papillomatosis (RRP). To test hypothesis that is uniquely vulnerable infection, further develop a mouse model RRP, we assessed whether immunocompetent mice were or laryngeal infection MmuPV1. Methods Larynges collected from 405 adult infected oropharynx, oral cavity, anus,...
Laryngeal infection with low-risk human papillomaviruses can cause recurrent respiratory papillomatosis (RRP), a disease severe effects on vocal fold epithelium resulting in impaired voice function and communication. RRP research has been stymied by limited preclinical models. We recently reported murine model of laryngeal MmuPV1 immunodeficient mice. In the current study, we compare quantitative qualitative measures epithelial proliferation, apoptosis, differentiation, barrier between mice...
Experimental data for the fields of EM groundwaves propagating over cylindrical homogeneous paths and two-section mixed were obtained by microwave (4.765 GHz) modeling. The surfaces, which have a radius <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">20 \lambda_{0}</tex> , closely approximate spherical surfaces insofar as groundwave propagation is concerned. model curved tank was constructed stratified combination Plexiglas distilled water,...
The transient electric field response of a step-function current excited cable lying on the surface homogeneous and isotropic earth is considered. Attention focused upon that portion at earth's where either constant or decaying with time. This information appears to have application in measurement conductivity using single finite length grounded both ends. Then, by superposition, an array equally spaced parallel cables also studied.