A5060057635- Protein Degradation and Inhibitors
- Epigenetics and DNA Methylation
- Chronic Lymphocytic Leukemia Research
- Cancer Genomics and Diagnostics
- Immunodeficiency and Autoimmune Disorders
- Glycosylation and Glycoproteins Research
- RNA modifications and cancer
- Acute Myeloid Leukemia Research
- Genomics and Chromatin Dynamics
- Glioma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
Children's National
2024
Carilion Clinic
2024
Virginia Tech
2024
University of California, San Diego
2018
University of California, Los Angeles
2018
Genetic drivers of cancer can be dysregulated through epigenetic modifications DNA. Although the critical role DNA 5-methylcytosine (5mC) in regulation transcription is recognized, functions other non-canonical remain obscure. Here, we report identification novel N6-methyladenine (N6-mA) human tissues and implicate this mark disease, specifically highly malignant brain glioblastoma. Glioblastoma markedly upregulated N6-mA levels, which co-localized with heterochromatic histone modifications,...
Abstract BACKGROUND Central nervous system (CNS) sarcomas are rare mesenchymal non-meningothelial tumors accounting for 0.2% of brain tumors. Due to their rarity, there is a lack substantive clinical, histological and molecular data. METHODS Patients diagnosed with primary CNS were identified through several international collaborations. DNA methylation profiles generated using 850K microarray assays, followed by unsupervised hierarchical clustering t-SNE analyses. Additionally, targeted...