A5052083915- Radiopharmaceutical Chemistry and Applications
- Synthesis and Biological Evaluation
- Monoclonal and Polyclonal Antibodies Research
- Macrophage Migration Inhibitory Factor
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Clostridium difficile and Clostridium perfringens research
- COVID-19 Impact on Reproduction
- Mosquito-borne diseases and control
- Maternal and fetal healthcare
- Viral gastroenteritis research and epidemiology
- Microscopic Colitis
- Pneumonia and Respiratory Infections
- Viral Infections and Vectors
- Maternal Mental Health During Pregnancy and Postpartum
- Nosocomial Infections in ICU
- Animal Virus Infections Studies
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Respiratory viral infections research
- Viral Infections and Outbreaks Research
- Immune Cell Function and Interaction
- Antibiotic Resistance in Bacteria
Korea Advanced Institute of Science and Technology
2023-2024
Korea University
2021-2023
Korea University Medical Center
2022-2023
Dabie bandavirus (DBV) is an emerging tick-borne virus that causes severe fever with thrombocytopenia syndrome (SFTS) in infected patients. Human SFTS symptoms progress from fever, fatigue, and muscle pain to the depletion of white blood cells platelets fatality rates up 30%. The recent spread its vector tick over 20 states United States increases potential for outbreaks beyond East Asia. Thus, development vaccine control this rapidly a high priority. In study, we applied self-assembling...
We investigated how differences in age, sex, or vaccine type can affect humoral and cellular immune responses after vaccination with vector (ChAdOx1 nCoV-19), mix-and-match (first, ChAdOx1 nCoV-19, second, BNT162b2), mRNA (BNT162b2 mRNA-1273) vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Venous blood was collected from 573 subjects (vector, 396; mix-and-match, 96; mRNA, 81) before the first (
To overcome the limited efficacy of immune checkpoint blockade, there is a need to find novel cancer immunotherapeutic strategies for optimal treatment cancer. The anti-4-1BB×PDL1 bispecific antibody-ABL503 (also known as TJ-L14B)-was designed simultaneously target PDL1 and 4-1BB demonstrated strong antitumor T-cell responses without considerable toxicity. In this study, we investigated mechanisms by which combination ABL503 anti-PD1 blockade affected reinvigoration exhausted...
Abstract Purpose: Regulatory T cells (Tregs) exert immunosuppressive functions and hamper antitumor immune responses in the tumor microenvironment. Understanding heterogeneity of intratumoral Tregs, how it changes with progression, will provide clues regarding novel target molecules Treg-directed therapies. Experimental Design: From 42 patients renal cell carcinoma 5 ovarian cancer, from peripheral blood were isolated. We performed multicolor flow cytometry RNA-sequencing to characterize...
This study aimed to describe the maternal, obstetrical, and neonatal outcomes in pregnant women with coronavirus disease 2019 (COVID-19) identify predictors associated severity of COVID-19.This multicenter observational included consecutive admitted because COVID-19 confirmed using reverse transcriptase-polymerase chain reaction (RT-PCR) test at 15 hospitals Republic Korea between January 2020 December 2021.A total 257 62 newborns were this study. Most patients developed during third...
Abstract Background This study aimed to develop and validate a clinical prediction rule screen older patients at risk of being toxigenic Clostridioides difficile carriers the time hospital admission. Methods retrospective case-control was performed university-affiliated hospital. Active surveillance using real-time polymerase chain reaction (PCR) assay for toxin genes C. conducted among (≥ 65 years) upon admission Division Infectious Diseases our institution. drawn from derivative cohort...
<div>AbstractPurpose:<p>To overcome the limited efficacy of immune checkpoint blockade, there is a need to find novel cancer immunotherapeutic strategies for optimal treatment cancer. The anti–4-1BB×PDL1 bispecific antibody—ABL503 (also known as TJ-L14B)—was designed simultaneously target PDL1 and 4-1BB demonstrated strong antitumor T-cell responses without considerable toxicity. In this study, we investigated mechanisms by which combination ABL503 anti-PD1 blockade affected...
This study compared the clinical outcomes and safety of meropenem–colistin versus meropenem–tigecycline in treatment adult patients with carbapenem-resistant Acinetobacter baumannii (CRAB) pneumonia. A retrospective observational CRAB pneumonia was performed at a 1048-bed university-affiliated hospital Republic Korea between June 2013 January 2020. All initially treated were those to evaluate in-hospital mortality adverse events. Altogether, 66 prescribed 24 included. had nosocomial...
The present study aimed to compare the clinical characteristics and outcomes between pregnant women non-pregnant of childbearing age (20-49 years old) diagnosed with coronavirus disease 2019 (COVID-19) during initial stage COVID-19 pandemic in Republic Korea.This nationwide observational included information patients collected by Korea Disease Control Prevention Agency from January 2020 April 2021.Among 5,647 patients, 2,444 (43.3%) were 19 pregnant.None died.However, 4 deaths occurred among...
<div>AbstractPurpose:<p>Regulatory T cells (Tregs) exert immunosuppressive functions and hamper antitumor immune responses in the tumor microenvironment. Understanding heterogeneity of intratumoral Tregs, how it changes with progression, will provide clues regarding novel target molecules Treg-directed therapies.</p>Experimental Design:<p>From 42 patients renal cell carcinoma 5 ovarian cancer, from peripheral blood were isolated. We performed multicolor flow cytometry...
<p>Supplementary Figures S1-11</p>
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<div>AbstractPurpose:<p>To overcome the limited efficacy of immune checkpoint blockade, there is a need to find novel cancer immunotherapeutic strategies for optimal treatment cancer. The anti–4-1BB×PDL1 bispecific antibody—ABL503 (also known as TJ-L14B)—was designed simultaneously target PDL1 and 4-1BB demonstrated strong antitumor T-cell responses without considerable toxicity. In this study, we investigated mechanisms by which combination ABL503 anti-PD1 blockade affected...
<p>Supplementary Figures S1-7</p>
Abstract An effective delivery platform is crucial for the development of mRNA vaccines and therapeutics. Here, a versatile utilizing cholesterol‐modified oligonucleotides (L‐oligo) that bind to within lipid nanoparticles (LNP), enables into target cells introduced. incorporated LNPs via linkage with L‐oligo, termed oligonucleotide‐linked LNP (lnLNP), superior in cellular uptake transfection efficiency vitro vivo, compared conventional formulations. It further applied lnLNP as an vaccine...
<div>AbstractPurpose:<p>Regulatory T cells (Tregs) exert immunosuppressive functions and hamper antitumor immune responses in the tumor microenvironment. Understanding heterogeneity of intratumoral Tregs, how it changes with progression, will provide clues regarding novel target molecules Treg-directed therapies.</p>Experimental Design:<p>From 42 patients renal cell carcinoma 5 ovarian cancer, from peripheral blood were isolated. We performed multicolor flow cytometry...
Dabie Bandavirus (DBV), previously known as Severe Fever with Thrombocytopenia Syndrome (SFTS) Virus, induces a characteristic thrombocytopenia mortality rate ranging from 12% to high 30%. The sero-prevalence of DBV in healthy people is not significantly different among age groups, but clinically diagnosed SFTS patients are older than ~50 years, suggesting that the critical risk factor for morbidity and mortality. Accordingly, our immune-competent ferret model demonstrates an (>4 years...
Abstract We evaluated the performance of SARS-CoV-2 assays in vaccinated group using receptor-binding domain antibody (RBD Ab assay), neutralizing assay (nAb and interferon-gamma release (IGR assay). also compared based on vaccine type a large population. collected 1,851 samples from individuals with vector, mix-and-match (MM), mRNA vaccines. The RBD was assessed by IgG II Quant (Abbott Laboratories, Sligo, Ireland), (Beckman Coulter, CA, USA), anti-SARS-CoV-2 S (Roche Diagnostics GmbH,...