A5061300093- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- Renal and related cancers
- Cystic Fibrosis Research Advances
- Ion Transport and Channel Regulation
- MRI in cancer diagnosis
- Dialysis and Renal Disease Management
- Gallbladder and Bile Duct Disorders
- Renal cell carcinoma treatment
- Traditional Chinese Medicine Studies
- Traditional Chinese Medicine Analysis
- Endometriosis Research and Treatment
- Hormonal Regulation and Hypertension
- Inflammatory Biomarkers in Disease Prognosis
- Advanced Neuroimaging Techniques and Applications
- Medicinal Plants and Bioactive Compounds
- Antiplatelet Therapy and Cardiovascular Diseases
- Berberine and alkaloids research
- Pharmacogenetics and Drug Metabolism
- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
- Fungal Biology and Applications
Zhejiang Chinese Medical University
2011-2025
Hangzhou Hospital of Traditional Chinese Medicine
2011-2025
Zhejiang Provincial Hospital of TCM
2024
Zhejiang Hospital
2023
CM Hospital
2023
Southwest Medical University
2023
Zhejiang University
2022
Maintenance hemodialysis patients are at increased risk of cardiovascular complications and mortality following COVID-19 infection due to compromised immune function. This study aims evaluate the effect vaccination (CoronaVac) on cardiac function survival in this population. Background/Objectives: aimed effects CoronaVac echocardiographic parameters, BNP levels, rates maintenance patients. By comparing vaccinated unvaccinated patients, we sought assess whether provides a protective...
Maintenance hemodialysis patients are at increased risk of cardiovascular complications and mortality following COVID-19 infection due to compromised immune function. This study aims evaluate the impact vaccine (CoronaVac) on cardiac function survival in this population. Background/Objectives: We aimed examine whether CoronaVac vaccination affects heart rates maintenance patients. Specifically, we assessed changes ultrasound (echocardiographic) measurements, B-type natriuretic peptide (BNP)...
Objective . Hyperuricemia (HUA) is a common metabolic disease caused by disordered purine metabolism. We aim to reveal the mechanisms underlying anti‐HUA function of Simiao pill and provide therapeutic targets. Methods pill‐related targets were obtained using Herbal Ingredients’ Targets (HIT), Traditional Chinese Medicine Systems Pharmacology (TCMSP), Integrated Database (TCMID). HUA‐associated retrieved from GeneCards, DisGeNET, Therapeutic (TTD). Protein‐protein interaction (PPI) network...
Abstract Background Enterococcus casseliflavus is a rare pathogenic bacterium that characterized by vancomycin resistance and can lead to multiple infections in the human body. This report describes case of polycystic intrahepatic infection with E. which necessitated antibiotic treatment surgical intervention involving cystic drainage. Case Presentation A 59-year-old woman, long-term hemodialysis patient, was hospitalized due 5-day history fever, abdominal pain, diarrhea, were possibly...
Podocyte damage is common in many renal diseases characterized by proteinuria. Transient receptor potential cation channel protein 6 (TRPC6) plays an important role function through its regulation of intracellular Ca2+ influx and RhoA/ROCK pathways. Chinese herb Stephania tetrandra, with the main active component being tetrandrine, has been used for treatment various kidney several years shown a positive effect. This study aimed at investigating effect mechanism tetrandrine podocyte induced...
Membranous glomerulopathy (MGN) is an autoimmune kidney disease that the primary cause of nephrotic syndrome (NS) in adults. Tetrandrine, a bisbenzylisoquinoline alkaloid, known to have numerous pharmacological effects. In this study, network pharmacology analysis and experimental validation were conducted analyze mechanisms by which tetrandrine functions as therapeutic intervention for MGN. A systematic method was applied identify potential targets determine mechanism MGN treatment. Heymann...
Background. Fangji Huangqi decoction (FHD) is a traditional Chinese medicine formula that has the potential efficacy for nephrotic syndrome (NS) treatment. This study aims to explore effects and underlying mechanisms of FHD against NS via network pharmacology in vivo experiments. Methods. The bioactive compounds targets were retrieved from TCMSP database. NS-related collected GeneCards DisGeNET databases. compound-target protein-protein interaction networks constructed by Cytoscape 3.8...
Tetrandrine (Tet), a compound found in traditional Chinese medicine, presents the protective effect for kidney function. Our study is aimed at clarifying efficacy and underlying mechanism of Tet on podocyte injury. In this study, injury was induced rats with adriamycin (ADR), MPC5 podocytes were constructed TRPC6 overexpression. We that treatment reduced levels proteinuria, serum creatinine, blood urea nitrogen increased plasma albumin ADR-induced rats. intracellular Ca2+ influx apoptosis...
At present, both 16G and 18G needles are used for percutaneous renal biopsy in China. This study aimed to compare the efficacy safety of performed with needle vs. needle.The data patients who underwent at our hospital between January 2015 December 2019 were retrospectively analyzed. The number glomeruli obtained by puncture postoperative complications compared undergoing needles. Continuous variables t test or Mann-Whitney U test, categorical chi-square test. Correlation analysis was examine...
Abstract Background: Enterococcus casseliflavus is a rare pathogenic bacterium that characterized by vancomycin resistance and can lead to multiple infections in the human body. This report describes case of polycystic intrahepatic infection with E. which necessitated antibiotic treatment surgical intervention involving cystic drainage. Case Presentation: A 59-year-old woman, long-term hemodialysis patient, was hospitalized due 5-day history fever, abdominal pain, diarrhea, were possibly...
Introduction: Renal interstitial inflammation often presents in immunoglobulin A nephropathy (IgAN), but its predictive role kidney disease progression remains controversial. Methods: This retrospective two-center cohort study included 1,420 adult IgAN patients between January 2003 and May 2018 followed for a median of approximately 7 years at two Chinese hospitals. The predictor was renal within the total cortical interstitium (none/mild [0–25%], moderate [26–50%], or severe [>50%]). For...
This study analyzed 550 hemodialysis patients, 469 unvaccinated and 81 vaccinated against COVID-19, to assess the impact on infection rates, mortality, clinical/laboratory parameters. Gender distribution was similar (p = 0.209), but group’s median age significantly lower 0.005). Hospitalization rates showed no significant difference 0.987), while mortality in group 0.041). Only uric acid levels were higher 0.009); other parameters, including creatinine B-type natriuretic peptide,...
Zhilong Huoxue Tongyu capsule (ZLHX) is a traditional Chinese medicinal compound preparation, which exhibits obvious therapeutic effects on aspirin resistance (AR). However, the mechanism of ZLHX AR rarely reported.
ABSTRACT Background: To evaluate the effectiveness and safety of uremic clearance granules for treating stages 3 to 5 chronic kidney disease (CKD), provide evidence-based support clinical application clearance. Methods: All randomized controlled trials (RCTs) addressing use treatment CKD were collected from China Biology Medicine (CBM) database, National Knowledge Infrastructure (CNKI), WanFang Data, PubMed, Cochrane Library, Web Science. After two researchers had independently screened...
Objective To analyze the risk factors for large renal hematoma caused by percutaneous biopsy (PRB) in order to provide evidence early clinical prevention and Effective nursing. Methods The data of 707 patients who underwent PRB nephrology department Hangzhou Hospital Traditional Chinese Medicine from January 2016 2017 were retrospectively identified. Demographic collected, including general status (gender, age, body mass index, histological diagnosis, associated diseases), laboratory...
Abstract Podocytes have become a crucial target for kidney disease. Tetrandrine (TET), the main active component of Chinese medicine formula Fangji Huangqi Tang, has shown positive effect on various renal diseases. We aimed to investigate and mechanism TET podocytes. The targeting relationship between microRNA (miR)-150-5p nephrosis 1 (NPHS1) was determined by dual-luciferase reporter gene assay. Cell proliferation, migration, apoptosis were detected cell counting kit-8, Transwell, flow...