A5022434125- Renal Diseases and Glomerulopathies
- Complement system in diseases
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Cell Adhesion Molecules Research
- Ion Transport and Channel Regulation
- Hormonal Regulation and Hypertension
- Platelet Disorders and Treatments
- Renal and Vascular Pathologies
- Health Systems, Economic Evaluations, Quality of Life
- Natural Compounds in Disease Treatment
- Anesthesia and Neurotoxicity Research
- Central Venous Catheters and Hemodialysis
- Pancreatic function and diabetes
- Systemic Sclerosis and Related Diseases
- Autophagy in Disease and Therapy
- Inflammatory mediators and NSAID effects
- Antimicrobial Resistance in Staphylococcus
- Diabetes Treatment and Management
- Ginkgo biloba and Cashew Applications
- Endometriosis Research and Treatment
- Infectious Aortic and Vascular Conditions
- Electrolyte and hormonal disorders
- Bone Metabolism and Diseases
- Blood Coagulation and Thrombosis Mechanisms
Zhejiang Chinese Medical University
2020-2025
Hangzhou Hospital of Traditional Chinese Medicine
2020-2025
Zhejiang University
2022
CM Hospital
2022
Hangzhou Medical College
2006
Background With the global increase in chronic diseases, kidney disease (CKD) and stroke have become major public health concerns. This study aims to investigate relationship between estimated glomerular filtration rate (eGFR), urine albumin-to-creatinine ratio (UACR), incidence of a CKD population.
Background In diabetic patients, non-diabetic kidney disease (NDKD) may occur independently or alongside (DKD). This study explored the utility of biopsy in type 2 diabetes mellitus (T2DM) patients and predictability diagnosing DKD combined with NDKD using clinical laboratory data. Methods retrospective examines medical records T2DM who underwent percutaneous renal at Hangzhou TCM Hospital, Zhejiang Chinese Medical University, from 2012 to 2023. The patient’s demographic, clinical, blood...
Purpose: This study investigated the mechanism of TSF in treating DN through network pharmacology, molecular docking, and experimental validation. Methods: To identify critical active ingredients, targets, genes TSF, multiple databases were utilized for screening purposes. The drug-compound-target was constructed using Cytoscape 3.9.1 software topological analysis. protein interaction relationship analyzed String database platform. Metascape conducted enrichment analysis on key targets Gene...
Podocyte damage is common in many renal diseases characterized by proteinuria. Transient receptor potential cation channel protein 6 (TRPC6) plays an important role function through its regulation of intracellular Ca2+ influx and RhoA/ROCK pathways. Chinese herb Stephania tetrandra, with the main active component being tetrandrine, has been used for treatment various kidney several years shown a positive effect. This study aimed at investigating effect mechanism tetrandrine podocyte induced...
Background. Fangji Huangqi decoction (FHD) is a traditional Chinese medicine formula that has the potential efficacy for nephrotic syndrome (NS) treatment. This study aims to explore effects and underlying mechanisms of FHD against NS via network pharmacology in vivo experiments. Methods. The bioactive compounds targets were retrieved from TCMSP database. NS-related collected GeneCards DisGeNET databases. compound-target protein-protein interaction networks constructed by Cytoscape 3.8...
Tetrandrine (Tet), a compound found in traditional Chinese medicine, presents the protective effect for kidney function. Our study is aimed at clarifying efficacy and underlying mechanism of Tet on podocyte injury. In this study, injury was induced rats with adriamycin (ADR), MPC5 podocytes were constructed TRPC6 overexpression. We that treatment reduced levels proteinuria, serum creatinine, blood urea nitrogen increased plasma albumin ADR-induced rats. intracellular Ca2+ influx apoptosis...
Alport syndrome and C3 glomerulonephritis (C3GN) are rare kidney diseases, frequently responsible for familial haematuria, proteinuria, renal impairment. With the rapid development of molecular genetic testing, causes have been restricted mostly to variants in COL4A5 or COL4A3/COL4A4 genes. Moreover, a broad range contributors complement complement-regulating proteins definitely implicated pathogenesis C3GN.We sought family with persistent microscopic haematuria associated failure....
Introduction: Renal interstitial inflammation often presents in immunoglobulin A nephropathy (IgAN), but its predictive role kidney disease progression remains controversial. Methods: This retrospective two-center cohort study included 1,420 adult IgAN patients between January 2003 and May 2018 followed for a median of approximately 7 years at two Chinese hospitals. The predictor was renal within the total cortical interstitium (none/mild [0–25%], moderate [26–50%], or severe [>50%]). For...
The aim of this study was to investigate the prognostic value mesangial IgM deposition in a long-term follow-up cohort patients with immunoglobulin A nephropathy (IgAN). retrospective analysis clinicopathological data from 774 primary IgAN at Hangzhou Hospital Traditional Chinese Medicine between January 1, 2016, and December 31, 2018, conducted. Patients were categorized into end-event non-end-event groups according whether they reached renal composite endpoint, defined as ≥ 50% decline...
aHangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China bThe Second Clinical College cDepartment Nephrology, Hangzhou Zhejiang,People's Hansheng Fang and Xiaoang Ye contributed equally this work share first authorship. Sponsorships or competing interests that may be relevant content are disclosed at the end article Published online ■ *Corresponding author. Address: 453 Stadium Road, West Lake District, 310007, China. E-mail...
Abstract Background Excessive salt intake is associated with the deterioration of chronic kidney disease (CKD). Aldosterone also known as an independent risk factor for injury. Dietary sodium acts a main stimulator in aldosterone-mediated Hence, this study aimed to further investigate renal protective effects and safety low-sodium diet combination spironolactone (SPL) stage 1-3a CKD. Methods This single-center, SPL-blinded randomized controlled trial recruited patients CKD, into three...
This study aims to investigate the clinical characteristics of enterococcus-associated peritonitis in patients with peritoneal dialysis (PD).In this retrospective study, PD-associated enterococcal (Group E) who were treated our center between January 2010 and September 2020 included. Patients streptococcus S) coagulase-negative staphylococcus CNS) matched 1:1 as cohort-control groups. The prognosis these analyzed.A total 21 episodes noted nine males females, an average age 60.33±14.79 years...
Abstract Background Alport syndrome and C3 glomerulonephritis (C3GN) are rare kidney diseases, frequently responsible for familial haematuria, proteinuria, renal impairment. With the rapid development of molecular genetic testing, causes have been restricted mostly to variants in COL4A5 or COL4A3/COL4A4 genes. Moreover, a broad range contributors complement complement-regulating proteins definitely implicated pathogenesis C3GN. Methods We sought family with persistent microscopic haematuria...
Abstract Background Alport syndrome and C3GN are all rare kidney diseases frequently responsible for familial hematuria, proteinuria and/or coexistent renal impairment. With the rapid development of molecular genetic testing, have been restricted mostly to causal variants in COL4A5 or COL4A3/COL4A4 genes. And a broad range contributors complement complement-regulating proteins definitely implicate pathogenesis C3GN. Methods We sought family with persistent microscopic hematuria associated...
Abstract Background Alport syndrome and C3 glomerulonephritis (C3GN) are rare kidney diseases, frequently responsible for familial haematuria, proteinuria, renal impairment. With the rapid development of molecular genetic testing, causes have been restricted mostly to variants in COL4A5 or COL4A3/COL4A4 genes. Moreover, a broad range contributors complement complement-regulating proteins definitely implicated pathogenesis C3GN. Methods We sought family with persistent microscopic haematuria...
Abstract Background Alport syndrome and C3 glomerulonephritis (C3GN) are rare kidney diseases, frequently responsible for familial haematuria, proteinuria, renal impairment. With the rapid development of molecular genetic testing, causes have been restricted mostly to variants in COL4A5 or COL4A3/COL4A4 genes. Moreover, a broad range contributors complement complement-regulating proteins definitely implicated pathogenesis C3GN. Methods We sought family with persistent microscopic haematuria...
Abstract Objective: This study aimed to investigate the association between patient clinical characteristics and technique failure in peritoneal dialysis-related peritonitis (PDRP). The risk factors associated with failure-related effect of on survival were also assessed. Methods We retrospectively reviewed patients PDRP January 1, 2010, February 2016. Relevant demographic, biochemical, data collected. Univariate multivariate logistic regression analyses used determine predictors. Patients...