A5060208736- Metabolomics and Mass Spectrometry Studies
- Gut microbiota and health
- Food composition and properties
- Diet and metabolism studies
- Plant biochemistry and biosynthesis
- Nutritional Studies and Diet
- Advanced Chemical Sensor Technologies
- Microbial Metabolites in Food Biotechnology
- Natural product bioactivities and synthesis
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Spectroscopy and Chemometric Analyses
- GABA and Rice Research
- Infant Nutrition and Health
- Enzyme Production and Characterization
- Analytical Chemistry and Chromatography
- Meat and Animal Product Quality
- Nutrition and Health in Aging
- Probiotics and Fermented Foods
- Diabetes and associated disorders
- Fatty Acid Research and Health
- Phytochemicals and Antioxidant Activities
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Fermentation and Sensory Analysis
- Proteins in Food Systems
- Muscle metabolism and nutrition
University of Copenhagen
2016-2025
Rigshospitalet
2024
Takeda (Japan)
2024
Haemophilia Foundation Australia
2020
Japan Lutheran College
2020
Sociedade Brasileira de Econometria
2020
Denver School of Nursing
2020
Evaluation of GC–MS data may be challenging due to the high complexity including overlapped, embedded, retention time shifted and low S/N ratio peaks. In this work, we demonstrate a new approach, PARAFAC2 based Deconvolution Identification System (PARADISe), for processing raw data. PARADISe is computer platform independent freely available software incorporating number newly developed algorithms in coherent framework. It offers solution analysts dealing with complex chromatographic allows...
Starch nanoparticles (ss-sNPs) are attractive for numerous applications due to their non-toxicity, environmentally friendly nature, readily available raw materials worldwide, and biodegradability. However, the heterogeneous nature of starch makes it a challenge prepare homogeneous ss-sNP (ss-sNP). The lack existing preparation methods ss-sNPs related small size with high quality has been limiting practical applications. In this study, we have developed new method by combining...
Abstract Triterpenoid saponins are bioactive metabolites that have evolved recurrently in plants, presumably for defense. Their biosynthesis is poorly understood, as the relationship between bioactivity and structure. Barbarea vulgaris only crucifer known to produce saponins. Hederagenin oleanolic acid cellobioside make some B. plants resistant important insect pests, while other, susceptible different Resistance could be caused by glucosylation of sapogenins. We identified four family 1...
Whey is the largest volume co-product of dairy industry and over last two centuries, a significant amount research has been dedicated to uncover its chemical composition, better understand biological activities whey constituents. However, detailed composition low-molecular weight components, especially non-protein nitrogen, not fully elucidated systematic approach identify quantify this partially unknown fraction required for production new value-added high-quality products. This review...
The ability to evolve novel metabolites has been instrumental for the defence of plants against antagonists. A few species in Barbarea genus are only crucifers known produce saponins, some which make resistant specialist herbivores, like Plutella xylostella, diamondback moth. Genetic mapping vulgaris revealed that genes saponin biosynthesis not clustered but located different linkage groups. Using co-location with quantitative trait loci (QTLs) resistance, transcriptome and genome sequences,...
Driven by the growing recognition of influence gut microbiota (GM) on human health and disease, there is a rapidly increasing interest in understanding how dietary components, pharmaceuticals pre- probiotics GM.
Lipoproteins and their subfraction profiles have been associated to diverse diseases including Cardio Vascular Disease (CVD). There is thus a great demand for measuring quantifying the lipoprotein profile in an efficient accurate manner. Nuclear Magnetic Resonance (NMR) spectroscopy uniquely able measure of blood sample non-destructively due its sensitivity both lipid chemistry lipid-micellar physics. However, NMR spectra must be scaled/regressed primary method reference, such as...
Abstract When humans age, changes in body composition arise along with lifestyle‐associated disorders influencing fitness and physical decline. Here we provide a comprehensive view of dietary intake, activity, gut microbiota (GM), host metabolome relation to 207 community‐dwelling subjects aged +65 years. Stratification on anthropometric/body composition/physical performance measurements (ABPm) variables identified two phenotypes (high/low‐fitness) clearly linked GM, patterns. Strikingly,...
Phytocannabinoids are a group of plant-derived metabolites that display wide range psychoactive as well health-promoting effects. The production pharmaceutically relevant cannabinoids relies on extraction and purification from cannabis (Cannabis sativa) plants yielding the major constituents, Δ9-tetrahydrocannabinol cannabidiol. Heterologous biosynthesis in Nicotiana benthamiana or Saccharomyces cerevisiae may provide cost-efficient rapid future platforms to acquire pure high quantities both...
Beyond the main bulk components of cereals such as polysaccharides and proteins, lower concentration secondary metabolites largely contribute to nutritional value. This paper outlines a comprehensive protocol for GC-MS metabolomic profiling phenolics organic acids in grains, performance which is demonstrated through comparison metabolite profiles northern European cereal crops: wheat, barley, oat rye. Phenolics were extracted using acidic hydrolysis, trimethylsilylated new method based on...
There is an ever-increasing trend in advanced food analysis and foodomics to use more sophisticated analytical platforms that generate large complex data structures, which turn require tools for converting into information.The choice of multivariate chemometric methods primarily determined by the design study, type data, conclusions sought.In order validate models, scientists are required have basic knowledge be familiar with variance structure investigated data.This review outlines some key...
A previous study has shown effects of the New Nordic Diet (NND) to stimulate weight loss and lower systolic diastolic blood pressure in obese Danish women men a randomized, controlled dietary intervention study. This work demonstrates long-term metabolic NND as compared with an Average (ADD) plasma reveals associations between changes health beneficial including loss. total 145 individuals completed samples were taken along clinical examinations before started (week 0) after 12 26 weeks. The...
Lipoprotein profiling of human blood by 1H nuclear magnetic resonance (NMR) spectroscopy is a rapid and promising approach to monitor health disease states in medicine nutrition. However, lack standardization measurement protocols has prevented the use NMR-based lipoprotein metastudies. In this study, standardized NMR protocol was applied ring test performed across three different laboratories Europe on plasma serum samples from 28 individuals. Data evaluated terms (i) spectral differences,...
Summary Plants continuously evolve new defense compounds. One class of such compounds is triterpenoid saponins. A few species in the Barbarea genus produce saponins as only ones large crucifer family. However, molecular mechanism behind saponin biosynthesis and their role plant remains unclear. We used pathway reconstitution planta , enzymatic production vitro insect feeding assays, bioinformatics to identify a missing gene involved saponin‐based herbivore defense. tandem repeat eight CYP72A...