A5065962810- Diabetes Treatment and Management
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Advanced Causal Inference Techniques
- Pancreatic function and diabetes
- Genetic Associations and Epidemiology
- Health, Environment, Cognitive Aging
- Gene expression and cancer classification
- Veterinary Equine Medical Research
- Data Analysis with R
- Statistical Methods and Bayesian Inference
- Genetic Mapping and Diversity in Plants and Animals
- Sports Analytics and Performance
- Substance Abuse Treatment and Outcomes
- Diabetes and associated disorders
- Birth, Development, and Health
- Bipolar Disorder and Treatment
- Statistical Methods in Clinical Trials
- Bayesian Modeling and Causal Inference
- Bioinformatics and Genomic Networks
- Statistical Methods and Inference
- Breastfeeding Practices and Influences
- Time Series Analysis and Forecasting
- Schizophrenia research and treatment
- Global Maternal and Child Health
University of Copenhagen
2016-2025
VIVE - The Danish Center for Social Science Research
2023
Danish Medical Association
2023
University of Southern Denmark
2012-2019
Max Planck Institute for Mathematics
2011
Leipzig University
2011
University of Arizona
2005
Steno Diabetes Centers
1998-2003
Heart Foundation
2003
Objective To investigate whether a whole grain diet alters the gut microbiome and insulin sensitivity, as well biomarkers of metabolic health functionality. Design 60 Danish adults at risk developing syndrome were included in randomised cross-over trial with two 8-week dietary intervention periods comprising refined diet, separated by washout period ≥6 weeks. The response to interventions on composition sensitivity measures glucose lipid metabolism, functionality, inflammatory markers,...
Compared with the general population, patients schizophrenia have a 2- to 3-fold higher mortality rate primarily caused by cardiovascular disease. Previous interventions designed counteract antipsychotic-induced weight gain and cardiometabolic disturbances reported limited effects.
BackgroundAlcohol use disorder (AUD) is a chronic, relapsing brain that accounts for 5% of deaths annually, and there an urgent need to develop new targets therapeutic intervention. The glucagon-like peptide-1 (GLP-1) receptor agonist exenatide reduces alcohol consumption in rodents nonhuman primates, but its efficacy patients with AUD unknown.MethodsIn randomized, double-blinded, placebo-controlled clinical trial, treatment-seeking were assigned receive (2 mg subcutaneously) or placebo once...
Introduction Alcohol use disorder (AUD) is a massive burden for the individual, relatives and society. Despite this, treatment gap wide compared with other mental health disorders. Treatment options are sparse, only three Food Drug Administration (FDA)-approved pharmacotherapies. Glucagon-like peptide-1 (GLP-1) receptor agonists have shown promising effects in reducing alcohol consumption preclinical experiments, clinical trials high demand to investigate these potentially beneficial...
Focused and nontargeted approaches were used to assess the impact associated with introduction of new high-flux pathways in Arabidopsis thaliana by genetic engineering. Transgenic A. plants expressing entire biosynthetic pathway for tyrosine-derived cyanogenic glucoside dhurrin as accomplished insertion CYP79A1 , CYP71E1 UGT85B1 from Sorghum bicolor shown accumulate 4% dry-weight marginal inadvertent effects on plant morphology, free amino acid pools, transcriptome, metabolome. In a similar...
Adherence to a low-gluten diet has become increasingly common in parts of the general population. However, effects reducing gluten-rich food items including wheat, barley and rye cereals healthy adults are unclear. Here, we undertook randomised, controlled, cross-over trial involving 60 middle-aged Danish without known disorders with two 8-week interventions comparing (2 g gluten per day) high-gluten (18 day), separated by washout period at least six weeks habitual (12 day). We find that,...
Abstract Triterpenoid saponins are bioactive metabolites that have evolved recurrently in plants, presumably for defense. Their biosynthesis is poorly understood, as the relationship between bioactivity and structure. Barbarea vulgaris only crucifer known to produce saponins. Hederagenin oleanolic acid cellobioside make some B. plants resistant important insect pests, while other, susceptible different Resistance could be caused by glucosylation of sapogenins. We identified four family 1...
<h3>Introduction</h3> Bipolar disorder is an often disabling mental illness with a lifetime prevalence of 1%–2%, high risk recurrence manic and depressive episodes, lifelong elevated suicide substantial heritability. The course frequently characterised by progressive shortening interepisode intervals each increasing cognitive dysfunction in subset individuals this condition. Clinically, diagnostic boundaries between bipolar other psychiatric disorders such as unipolar depression are unclear...
Precision medicine based on big data promises to revolutionise disease prevention but increases the challenge of determining which abnormalities will be clinically important, argue <b>Henrik Vogt and colleagues</b>
Abstract Winter cress (Barbarea vulgaris) is resistant to a range of insect species. Some B. vulgaris genotypes are resistant, whereas others susceptible, herbivory by flea beetle larvae (Phyllotreta nemorum). Metabolites involved in resistance beetles were identified using an ecometabolomic approach. An F2 population representing the whole from full susceptibility was generated cross between susceptible and plant. This offspring evaluated with bioassay measuring ability survive on each that...
To investigate whether continued use of non-aspirin NSAID, low-dose aspirin, high-dose statins, allopurinol and angiotensin agents decreases the rate incident depression using Danish nationwide population-based registers.All persons in Denmark who purchased exposure medications interest between 1995 2015 a random sample 30% population was included study. Two different outcome measures were included, (i) diagnosis depressive disorder at psychiatric hospital as in-patient or out-patient (ii)...
Hypertension, cardiovascular diseases, and cerebrovascular diseases are associated with an increased risk of depression, but it remains unclear whether treatment antihypertensive agents decreases or increases this risk. The effects individual drugs also unknown. We used Danish population-based registers to systematically investigate the 41 most were altered incident depression. Analyses diuretics included for comparisons. Participants in study January 2005 followed until December 2015. Two...
Introduction Clozapine and olanzapine are some of the most effective antipsychotics, but both associated with weight gain relevant metabolic disturbances, including pre-diabetes diabetes. Non-pharmacological/behavioural interventions have had limited effects counteracting these adverse effects. Semaglutide, a glucagon-like peptide 1 receptor agonist, is approved for treatment type 2 diabetes obesity. We will investigate long-term add-on semaglutide once week versus placebo on status in...
Abstract In causal inference, parametric models are usually employed to address questions estimating the effect of interest. However, rely on correct model specification assumption that, if not met, leads biased estimates. Correct is challenging, especially in high-dimensional settings. Incorporating Machine Learning (ML) into analyses may reduce bias arising from misspecification, since ML methods do require a functional form relationship between variables. when predictions directly plugged...
OBJECTIVE Diabetes is associated with an increased risk of depression. Some antidiabetes agents, specifically metformin and pioglitazone, have been suggested to beneficial effects on depression, but associations between drugs depression not systematically investigated. RESEARCH DESIGN AND METHODS We combined four Danish population-based registers investigate whether the 20 most widely used orally administered were altered incident Analyses insulin included for comparisons. All persons in...
Objective To explore ehealth literacy, ability to actively engage with healthcare providers and health system navigation among pregnant immigrant women their descendants compared of Danish origin. Design setting A cross-sectional survey at antenatal clinics in 2016, Denmark. Participants Pregnant attending care (n=405). Outcome measures The eHealth Literacy Questionnaire (eHLQ) two domains from the Health (HLQ): navigation. Range response options for eHLQ (1–4) HLQ (1–5). With mixed-effect...
The human plasma-cell membrane differentiation antigen-1 (PC-1) has been shown to inhibit insulin receptor tyrosine kinase activity. Recently, a K121Q polymorphism in the PC-1 gene was found Sicilian population and be strongly associated with resistance. objectives of present investigation were examine Danish Caucasian whether variant type 2 diabetes or, glucose-tolerant subjects, impaired whole-body sensitivity. We genotyped 404 diabetic patients that allele frequency 0.14 (95% CI...
Incisional infections are common in horses after colic surgery. There is a clinical impression that the use of stent bandage reduces prevalence such infections.To determine effect on likelihood incisional infection ventral midline exploratory coeliotomy. It was hypothesised would reduce infection.Medical records underwent coeliotomy for between January 2005 and September 2011 were reviewed. Inclusion criteria animals had one survived at least 10 days Horses categorised into 2 groups:no-stent...
Critically ill patients are predisposed to venous thromboembolism. We hypothesized that higher doses of enoxaparin would improve thromboprophylaxis without increasing the risk bleeding. Peak anti-factor Xa (anti-Xa) levels 0.1 0.4 IU/ml reflect adequate for general ward patients. Studies conducted in orthopaedic demonstrated a statistically significant relationship between anti-Xa and wound haematoma thrombosis. Corresponding critically may well be higher, but have never been validated large...
Aims To examine whether physical activity as an adjunct to outpatient alcohol treatment has effect on consumption following participation in exercise intervention of six months' duration, and at 12 months after initiation. Methods The study is a randomized controlled with three arms: Patients allocated (A) usual, (B) usual supervised group exercise, (C) individual exercise. primary outcome measure was excessive drinking start completion the intervention. A logistic regression model used...
Treatment with most antipsychotics is associated an increased risk of weight gain and metabolic disturbances. In a randomized trial, we previously demonstrated that 16 weeks glucagon-like peptide-1 receptor agonist liraglutide treatment vs. placebo significantly reduced glucometabolic disturbances body in prediabetic, overweight/obese schizophrenia-spectrum disorder patients treated clozapine or olanzapine. The aim this study was to investigate whether the beneficial effects 16-week...