A5009819204- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Pancreatic and Hepatic Oncology Research
- Prostate Cancer Treatment and Research
- Nanoplatforms for cancer theranostics
- Microbial Natural Products and Biosynthesis
- Cancer-related Molecular Pathways
- Monoclonal and Polyclonal Antibodies Research
- RNA modifications and cancer
- PARP inhibition in cancer therapy
- RNA Interference and Gene Delivery
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Prostate Cancer Diagnosis and Treatment
- Ergonomics and Musculoskeletal Disorders
- Immune cells in cancer
- Animal Genetics and Reproduction
- Infant Nutrition and Health
- DNA Repair Mechanisms
- Inflammatory Biomarkers in Disease Prognosis
- Cancer-related gene regulation
- Cancer therapeutics and mechanisms
- Esophageal Cancer Research and Treatment
- Bone and Dental Protein Studies
- Cancer Cells and Metastasis
Peking University
2017-2024
Peking University First Hospital
2017-2024
Anhui University of Traditional Chinese Medicine
2023-2024
Guangxi University of Science and Technology
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2022
Animal Science Research Institute
2020
Christie's
2017
European Association of Urology
2017
Creative Commons
2017
The present study aimed to evaluate the anti-tumor efficacy of epidermal growth factor receptor (EGFR)-targeting recombinant fusion protein Fv-LDP-D3 and its antibody-drug conjugate Fv-LDP-D3-AE against esophageal cancer. Fv-LDP-D3, consisting fragment variable (Fv) an anti-EGFR antibody, apoprotein lidamycin (LDP), third domain human serum albumin (D3), exhibited a high binding affinity for EGFR-overexpressing cancer cells, inhibited EGFR phosphorylation down-regulated inosine monophosphate...
To build a practical model for predicting the progression to castration-resistant prostate cancer (CRPC) after androgen deprivation therapy (ADT). In all, 185 patients with who had received ADT as primary at our institution, from 2003 2014, were retrospectively enrolled. The following clinical variables included in analysis: age, tumor, node, metastasis stage, Gleason score, risk groups of cancer, prostate-specific antigen (PSA) initiation ADT, PSA nadir velocity decline, and time nadir. Cox...
Yak milk, a high-quality is one of the best raw materials for dairy products and economically important to pastoral herdsmen. To make further understanding molecular differences in mammary tissues yaks with different milk production during lactation, this study, we took use RNA-seq perform high-throughput sequencing analysis gland transcriptomes both high-yielding yak low-yielding lactation. By comparison transcriptome data tissue low-yield yak, 144 differential genes were screened out,...
This study aims to investigate the molecular mechanisms by which YWHAG (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma) promotes metastasis in bladder cancer. Specifically, it seeks elucidate role of driving cancer cell invasion and its potential as a prognostic marker for progression. The expression pattern both primary metastatic tissues was analyzed using immunohistochemistry (IHC) determine correlation with clinical stage prognosis patients. functional...
Pentraxin 3 is considered an important inflammatory marker known to increase in patients with ischemic stroke, but the relationship between pentraxin and intracerebral hemorrhage mortality unclear. The purpose of this study investigate level serum its impact on prognosis 307 hemorrhage. During 5-year follow-up, rate was 22.5%. brain-dead higher than that control group (P < 0.05). Logistic regression analysis indicated a high correlation 95% (hazard ratio: 3.671; confidence interval:...
With the incidence of cervical cancer in women rising year by year, its impact on physical and mental health patients as well their families is becoming more significant. At present, hospitals often use intracavitary radiation therapy, therapy transfer bed a gynecological oncology medical auxiliary device plays an extremely important role. Therefore, for design beds, validation man-machine adaptability can help to optimize structure. The paper firstly imports three-dimensional model...
Objective To evaluate the risk factors and prognosis of high bladder recurrence developing after radical nephroureterectomy(RNU) for upper tract urothelial carcinoma (UTUC). Methods The data 148 UTUC patients who developed tumor RNU between January 2000 December 2013 was retrospectively studied. There were 69 males 79 females, aged from 34 to 82 years old(average 68 old). 83 accompanied with hydronephrosis. 80 renal pelvic carcinoma. 32 had history smoking. 24 ureteroscope. larger...
You have accessJournal of UrologyBladder Cancer: Upper Tract Transitional Cell Carcinoma II (MP82)1 Apr 2020MP82-04 THE COPY NUMBER VARIATION SIGNATURES IN UPPER TRACT UROTHELIAL CARCINOMA DEFINE DISTINCT SUBTYPES WITH PROGNOSTIC RELEVANCE Bao Guan, Huan Lu, Yuan Liang, Yanqing Gong, Shiming He, Qun Xuesong Li, Liqun Zhou*, and Weimin Ci GuanBao Guan More articles by this author , LuHuan Lu LiangYuan Liang GongYanqing Gong HeShiming He HeQun LiXuesong Li Zhou*Liqun Zhou* CiWeimin View All...
To analyze the differences and distinct features of immune cell infiltration between metastasis primary prostate cancer. We merged multiple datasets collected a total 2115 samples. Using single-sample Gene Sets Enrichment Analysis to calculate abundance fraction infiltration. Weighted-gene correlation network analysis was applied identify gene modules related Single-cell sequencing invasion assays were used validate effects on In metastatic cancer, score lower compared with benign...